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    Implantable devices and methods for measuring intraocular, subconjunctival or subdermal pressure and/or analyte concentration
    2.
    发明授权
    Implantable devices and methods for measuring intraocular, subconjunctival or subdermal pressure and/or analyte concentration 有权
    用于测量眼内，结膜下或皮下压力和/或分析物浓度的可植入装置和方法

    公开(公告)号：US09474487B2

    公开(公告)日：2016-10-25

    申请号：US13185277

    申请日：2011-07-18

    申请人： Roy S. Chuck ,  George Baerveldt ,  Jim-Son Chou

    发明人： Roy S. Chuck ,  George Baerveldt ,  Jim-Son Chou

    IPC分类号： A61B5/00 ,  A61F2/14 ,  A61B3/16

    CPC分类号： A61B3/16 ,  A61B5/0084 ,  A61B5/686 ,  A61B5/6867 ,  A61F2/14 ,  A61F2/16 ,  A61F2002/1681

    摘要： Methods, apparatus and systems for measuring pressure and/or for quantitative or qualitative measurement of analytes within the eye or elsewhere in the body. Optical pressure sensors and/or optical analyte sensors are implanted in the body and light is cast from an extracorporeal light source, though the cornea, conjunctiva or dermis, and onto a reflective element located within each pressure sensor or analyte sensor. The position or configuration of each sensor's reflective element varies with pressure or analyte concentration. Thus, the reflectance spectra of light reflected by the sensors' reflective elements will vary with changes in pressure or changes in analyte concentration. A spectrometer or other suitable instrument is used to process and analyze the reflectance spectra of the reflected light, thereby obtaining an indication of pressure or analyte concentration adjacent to the sensor(s). The wavelength of the interrogating beam of light may vary to control out potential interference or inaccuracies in the system.

    摘要翻译： 用于测量眼睛或身体其他部位的分析物的压力和/或定量或定性测量的方法，装置和系统。 将光学压力传感器和/或光学分析物传感器植入体内，并从体外光源（通过角膜，结膜或真皮）和位于每个压力传感器或分析物传感器内的反射元件上投射光。 每个传感器的反射元件的位置或配置随压力或分析物浓度而变化。 因此，由传感器的反射元件反射的光的反射光谱随着压力的变化或分析物浓度的变化而变化。 使用光谱仪或其他合适的仪器来处理和分析反射光的反射光谱，从而获得邻近传感器的压力或分析物浓度的指示。 询问光束的波长可能会变化，以控制系统中的潜在干扰或不准确。

    Implantable Devices and Methods for Measuring Intraocular, Subconjunctival or Subdermal Pressure and/or Analyte Concentration
    3.
    发明申请
    Implantable Devices and Methods for Measuring Intraocular, Subconjunctival or Subdermal Pressure and/or Analyte Concentration 有权
    用于测量眼内，结膜下或皮下压力和/或分析物浓度的植入式装置和方法

    公开(公告)号：US20120041552A1

    公开(公告)日：2012-02-16

    申请号：US13185277

    申请日：2011-07-18

    申请人： Roy S. Chuck ,  George Baerveldt ,  Jim-Son Chou

    发明人： Roy S. Chuck ,  George Baerveldt ,  Jim-Son Chou

    IPC分类号： A61B3/16 ,  A61F9/00 ,  A61B5/00 ,  A61F2/16

    CPC分类号： A61B3/16 ,  A61B5/0084 ,  A61B5/686 ,  A61B5/6867 ,  A61F2/14 ,  A61F2/16 ,  A61F2002/1681

    摘要： Methods, apparatus and systems for measuring pressure and/or for quantitative or qualitative measurement of analytes within the eye or elsewhere in the body. Optical pressure sensors and/or optical analyte sensors are implanted in the body and light is cast from an extracorporeal light source, though the cornea, conjunctiva or dermis, and onto a reflective element located within each pressure sensor or analyte sensor. The position or configuration of each sensor's reflective element varies with pressure or analyte concentration. Thus, the reflectance spectra of light reflected by the sensors' reflective elements will vary with changes in pressure or changes in analyte concentration. A spectrometer or other suitable instrument is used to process and analyze the reflectance spectra of the reflected light, thereby obtaining an indication of pressure or analyte concentration adjacent to the sensor(s). The wavelength of the interrogating beam of light may vary to control out potential interference or inaccuracies in the system.

    摘要翻译： 用于测量眼睛或身体其他部位的分析物的压力和/或定量或定性测量的方法，装置和系统。 将光学压力传感器和/或光学分析物传感器植入体内，并从体外光源（通过角膜，结膜或真皮）以及位于每个压力传感器或分析物传感器内的反射元件上投射光。 每个传感器的反射元件的位置或配置随压力或分析物浓度而变化。 因此，由传感器的反射元件反射的光的反射光谱随着压力的变化或分析物浓度的变化而变化。 使用光谱仪或其他合适的仪器来处理和分析反射光的反射光谱，从而获得邻近传感器的压力或分析物浓度的指示。 询问光束的波长可能会变化，以控制系统中的潜在干扰或不准确。

    Glaucoma implant
    5.
    发明授权
    Glaucoma implant 失效
    青光眼植入物

    公开(公告)号：US5558629A

    公开(公告)日：1996-09-24

    申请号：US917575

    申请日：1992-07-21

    申请人： George Baerveldt ,  Larry W. Blake ,  George M. Wright

    发明人： George Baerveldt ,  Larry W. Blake ,  George M. Wright

    IPC分类号： A61F9/00 ,  A61F9/007 ,  A61M1/00 ,  A61M27/00

    CPC分类号： A61M27/002 ,  A61F9/00781

    摘要： An implant for use in the treatment of glaucoma is disclosed wherein the implant comprises an elastomeric plate having a non-valved elastomeric drainage tube attached thereto. The plate is elliptical in-shape and curved so as to conform to the curvature of the eye. The plate is inserted into the eye in an incision made in the Tenon's capsule and sutured to the sclera. The drainage tube is tunnelled through the Tenon's capsule and cornea and inserted into the anterior chamber, thus providing patent fluid communication between the anterior chamber and the elastomeric plate. The flexible structure of the plate allows the plate to be easily inserted, thus reducing the surgical procedure length. In addition, the pliable material minimizes the risk of damage and trauma to surrounding tissues in the insertion process.

    摘要翻译： 公开了一种用于治疗青光眼的植入物，其中所述植入物包括具有连接到其上的非瓣膜弹性体引流管的弹性体板。 该板是椭圆形和弯曲的，以符合眼睛的曲率。 将板插入到Tenon胶囊中的切口中并缝合到巩膜上。 引流管穿过Tenon的胶囊和角膜，并插入前房，从而在前房和弹性体板之间提供专利流体连通。 板的柔性结构允许板容易地插入，从而减少手术过程长度。 此外，柔韧材料可以最大限度地减少插入过程中损伤周围组织的风险。

    GLAUCOMA DRAINAGE SHUNTS AND METHODS OF USE
    6.
    发明申请
    GLAUCOMA DRAINAGE SHUNTS AND METHODS OF USE 有权
    GLAUCOMA排水管和使用方法

    公开(公告)号：US20100114006A1

    公开(公告)日：2010-05-06

    申请号：US12265145

    申请日：2008-11-05

    申请人： George Baerveldt

    发明人： George Baerveldt

    IPC分类号： A61M39/00

    CPC分类号： A61F9/00781 ,  A61F9/007 ,  A61F2009/00891 ,  A61M27/002 ,  A61M2210/0612 ,  Y10S623/905

    摘要： A method of treating glaucoma in an eye utilizing an implanted shunt having an elastomeric plate and a non-valved elastomeric drainage tube. The plate is positioned over a sclera of the eye with an outflow end of the elastomeric drainage tube open to an outer surface of the plate. An inflow end of the drainage tube tunnels through the sclera and cornea to the anterior chamber of the eye. The drainage tube collapses upon initial insertion within an incision in the selera and cornea, or at a kink on the outside of the incision, but has sufficient resiliency to restore its patency over time. The effect is a flow restrictor that regulates outflow from the eye until a scar tissue bleb forms around the plate of the slunt. The plate desirably has a peripheral ridge and a large number of fenestrations, and a longer suturing tab extending from one side of the plate to enhance visibility and accessibility when suturing the shunt to the selera.

    摘要翻译： 一种使用具有弹性体板和非瓣膜弹性体引流管的植入分流器治疗眼睛中的青光眼的方法。 板被定位在眼睛的巩膜上方，弹性体排出管的流出端通向板的外表面。 引流管的流入端通过巩膜和角膜穿入眼睛的前房。 引流管在初次插入到切口和切口的切口中时，或者在切口外侧的扭结处折叠，但具有足够的弹性以恢复其随时间的通畅。 效果是限流器，其调节眼睛的流出，直到瘢痕组织在底部的平板周围形成气泡。 该板期望具有周边脊和大量的窗孔，以及从板的一侧延伸的更长的缝合片，以在将分流器缝合到丝锥时增强可见性和可接近性。

    Glaucoma implant with a temporary flow restricting seal
    8.
    发明授权
    Glaucoma implant with a temporary flow restricting seal 失效
    青光眼植入物临时流动限制密封

    公开(公告)号：US5476445A

    公开(公告)日：1995-12-19

    申请号：US283961

    申请日：1994-08-01

    申请人： George Baerveldt ,  Larry W. Blake

    发明人： George Baerveldt ,  Larry W. Blake

    IPC分类号： A61F9/007 ,  A61M27/00 ,  A61M5/00

    CPC分类号： A61F9/00781 ,  A61M27/002

    摘要： An implant for use in the treatment of glaucoma is disclosed wherein the implant comprises an elastomeric plate having a non-valved elastomeric drainage tube attached thereto. The plate is curved so as to conform to the spherical anatomy of the eyeball. An annular sloped wall extends from the plate and surrounds the opening of the drainage tube into the plate. The plate is inserted beneath Tenon's capsule and sutured to the sclera utilizing temporary and non-dissolving permanent sutures. The annular wall provides a temporary sealing surface against the sclera. The drainage tube is tunnelled through the sclera and cornea and inserted into the anterior chamber, thus providing fluid communication between the anterior chamber and the elastomeric plate. The annular wall around the tube forms a temporary seal which restricts the drainage of aqueous fluid until formation of the bleb is completed. After bleb formation occurs, the temporary sutures around the wall are removed or dissolve. Once the temporary sutures are gone, the portion of the plate that is not stitched to the sclera floats within the bleb and breaks the seal between the implant and the sclera. Once the seal is broken, unrestricted flow between the anterior chamber and bleb is maintained.

    摘要翻译： 公开了一种用于治疗青光眼的植入物，其中所述植入物包括具有连接到其上的非瓣膜弹性体引流管的弹性体板。 该板是弯曲的，以符合眼球的球形解剖结构。 环形斜壁从板延伸并且将排水管的开口包围到板中。 将板插入Tenon's胶囊下方，并使用临时和不溶解的永久性缝合线缝合至巩膜。 环形壁提供抵抗巩膜的临时密封表面。 引流管通过巩膜和角膜隧道并插入前房，从而在前房和弹性体板之间提供流体连通。 管周围的环形壁形成临时密封，其限制水性流体的排出，直到完成泡沫的形成。 在发生气泡形成之后，围绕壁的临时缝合线被去除或溶解。 一旦临时缝线消失，板上没有缝合到巩膜的部分在泡泡内漂浮，并破坏植入物和巩膜之间的密封。 一旦密封破裂，保持前房和泡沫之间的不受限制的流动。

    Method and apparatus for inserting a glaucoma implant in an anterior and posterior segment of the eye
    9.
    发明授权
    Method and apparatus for inserting a glaucoma implant in an anterior and posterior segment of the eye 失效
    将青光眼植入物插入眼睛的前部和后部的方法和装置

    公开(公告)号：US6050970A

    公开(公告)日：2000-04-18

    申请号：US853076

    申请日：1997-05-08

    申请人： George Baerveldt

    发明人： George Baerveldt

    IPC分类号： A61F9/007 ,  A61M5/00

    CPC分类号： A61F9/00781

    摘要： A method of treating glaucoma in an eye utilizing an implant is disclosed. The implant comprises an elastomeric plate having first and second surfaces and an non-valved elastomeric drainage tube. The plate is positioned over a sclera of said eye beneath Tenon's capsule, such that a portion of the plate extends into the anterior segment of the eye. The first end of said elastomeric drainage tube is open to said second surface of said plate. The second end of said drainage tube is tunneled through the sclera and cornea and inserted into the anterior chamber of said eye. Fluid communication is provided between said anterior chamber and a scar tissue bleb which forms around said implant. Preferably, a portion of the scar tissue bleb extends into the anterior segment of the eye and a portion of the scar tissue bleb extends into the posterior segment of the eye.

    摘要翻译： 公开了一种利用植入物治疗眼睛中的青光眼的方法。 植入物包括具有第一和第二表面的弹性体板和非阀门弹性体排出管。 该板位于Tenon's胶囊下面的所述眼睛的巩膜上，使得该板的一部分延伸到眼睛的前部。 所述弹性体引流管的第一端向所述板的所述第二表面开口。 所述引流管的第二端穿过巩膜和角膜并插入所述眼睛的前房。 在所述前房和围绕所述植入物形成的瘢痕组织泡沫之间提供流体连通。 优选地，疤痕组织的一部分泡沫延伸到眼睛的前部，并且一部分疤痕组织的泡状物延伸到眼睛的后部。

    Glaucoma implant
    10.
    发明授权
    Glaucoma implant 失效
    GLAUCOMA IMPLANT

    公开(公告)号：US5178604A

    公开(公告)日：1993-01-12

    申请号：US531010

    申请日：1990-05-31

    申请人： George Baerveldt ,  Larry W. Blake ,  George M. Wright

    发明人： George Baerveldt ,  Larry W. Blake ,  George M. Wright

    IPC分类号： A61F9/00 ,  A61F9/007 ,  A61M1/00 ,  A61M27/00

    CPC分类号： A61M27/002 ,  A61F9/00781

    摘要： An implant for use in the treatment of glaucoma is disclosed wherein the implant comprises an elastomeric plate having a non-valved elastomeric drainage tube attached thereto. The plate is elliptical in shape and curved so as to conform to the curvature of the eye. The plate is inserted into the eye in an incision made in the Tenon's capsule and sutured to the sclera. The drainage tube is tunnelled through the Tenon's capsule and cornea and inserted into the anterior chamber, thus providing patent fluid communication between the anterior chamber and the elastomeric plate. The flexible structure of the plate allows the plate to be easily inserted, thus reducing the surgical procedure length. In addition, the pliable material minimizes th risk of damage and trauma to surrounding tissues in the insertion process.

    摘要翻译： 公开了一种用于治疗青光眼的植入物，其中所述植入物包括具有连接到其上的非瓣膜弹性体引流管的弹性体板。 该板的形状为椭圆形并弯曲，以符合眼睛的曲率。 将板插入到Tenon胶囊中的切口中并缝合到巩膜上。 引流管穿过Tenon的胶囊和角膜，并插入前房，从而在前房和弹性体板之间提供专利流体连通。 板的柔性结构允许板容易地插入，从而减少手术过程长度。 此外，柔韧材料可以最大限度地减少插入过程中周围组织的损伤和创伤风险。