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公开(公告)号：US20090324501A1
公开(公告)日：2009-12-31
申请号：US12304267
申请日：2007-06-11
申请人： Rudolf Valenta , Margarete Focke-Tejkl , Birgit Linhart , Susanne Vrtala , Peter Valent , Renat Reininger , Susanne Spitzauer , Ines Swoboda , Marianne Van Hage , Hans Grönlund , Johanna Tinhofer , Kerstin Westritschnig , Theresia Popow-Kraupp
发明人： Rudolf Valenta , Margarete Focke-Tejkl , Birgit Linhart , Susanne Vrtala , Peter Valent , Renat Reininger , Susanne Spitzauer , Ines Swoboda , Marianne Van Hage , Hans Grönlund , Johanna Tinhofer , Kerstin Westritschnig , Theresia Popow-Kraupp
IPC分类号： A61K39/35 , C07K14/00 , C07H21/04 , C07K16/00 , A61K39/395 , A61P31/12 , C07K14/415 , C12N15/63 , C12N5/10 , A61K49/00 , A61P37/08
CPC分类号： C07K14/415 , A61K39/35 , A61K39/36 , A61K2039/5256 , A61K2039/5258 , C07K19/00 , C12N2770/32734
摘要： The present invention relates to a hypoallergenic protein consisting of at least one hypoallergenic molecule derived from an allergen, which is fused or conjugated to at least one second non-allergenic protein or fragment thereof.
摘要翻译： 本发明涉及由至少一种衍生自变应原的低变应原分子组成的低变应原性蛋白质，其与至少一种第二非致敏性蛋白质或其片段融合或缀合。
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公开(公告)号：US09296828B2
公开(公告)日：2016-03-29
申请号：US12304267
申请日：2007-06-11
申请人： Rudolf Valenta , Margarete Focke-Tejkl , Birgit Linhart , Susanne Vrtala , Peter Valent , Renate Reininger , Susanne Spitzauer , Ines Swoboda , Marianne Van Hage , Hans Grönlund , Johanna Tinhofer , Kerstin Westritschnig , Theresia Popow-Kraupp
发明人： Rudolf Valenta , Margarete Focke-Tejkl , Birgit Linhart , Susanne Vrtala , Peter Valent , Renate Reininger , Susanne Spitzauer , Ines Swoboda , Marianne Van Hage , Hans Grönlund , Johanna Tinhofer , Kerstin Westritschnig , Theresia Popow-Kraupp
IPC分类号： A61K38/00 , A61K39/00 , A61K39/35 , A61K39/36 , A61K39/385 , C07H21/02 , C07H21/04 , C12N15/00 , C07K19/00 , C07K14/415
CPC分类号： C07K14/415 , A61K39/35 , A61K39/36 , A61K2039/5256 , A61K2039/5258 , C07K19/00 , C12N2770/32734
摘要： The present invention relates to a hypoallergenic protein consisting of at least one hypoallergenic molecule derived from an allergen, which is fused or conjugated to at least one second non-allergenic protein or fragment thereof.
摘要翻译： 本发明涉及由至少一种衍生自变应原的低变应原分子组成的低变应原性蛋白质，其与至少一种第二非致敏性蛋白质或其片段融合或缀合。
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公开(公告)号：US20120171238A1
公开(公告)日：2012-07-05
申请号：US13395118
申请日：2010-09-10
申请人： Rudolf Valenta , Kavita Reginald , Kerstin Westritschnig , Birgit Linhart , Angelika Stöcklinger , Josef Thalhamer , Alexander M. Hirschi , Thomas Werfel , Elli Greisenegger , Tamara Kopp
发明人： Rudolf Valenta , Kavita Reginald , Kerstin Westritschnig , Birgit Linhart , Angelika Stöcklinger , Josef Thalhamer , Alexander M. Hirschi , Thomas Werfel , Elli Greisenegger , Tamara Kopp
IPC分类号： A61K39/085 , C12Q1/68 , G01N33/566 , C12N15/63 , A61P37/04 , A61P31/04 , C12N15/31 , C12Q1/14 , C07K14/31
CPC分类号： G01N33/6854 , A61K38/00 , A61K39/00 , C07K14/315 , G01N33/56938 , G01N2333/31 , G01N2800/202 , G01N2800/24
摘要： The invention discloses the use of a protein with an amino acid sequence according to SEQ. ID. NO. 1 or a naturally occurring fragment or variant thereof for identifying infections with S. aureus in a human sample. More specifically, IgE molecules specific for SEQ. ID. NO. 1 are detected in the sample of the patient. Many atopic dermatitis patients have IgE specific for SEQ. ID. NO. 1.
摘要翻译： 本发明公开了具有SEQ ID NO：1的氨基酸序列的蛋白质的用途。 ID。 没有。 1或其天然存在的片段或变体，用于鉴定人样品中金黄色葡萄球菌的感染。 更具体地，对SEQ ID NO：1特异性的IgE分子。 ID。 没有。 在患者样本中检测到1。 许多特应性皮炎患者对SEQ进行IgE特异性检测。 ID。 没有。 1。
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4.发明授权Hypoallergenic allergy vaccines based on the timothy grass pollen allergen Phl p 7 失效基于Timothy草花粉过敏原Phl p 7的低过敏性过敏疫苗公开(公告)号：US07425333B2
公开(公告)日：2008-09-16
申请号：US10529441
申请日：2003-09-25
申请人： Kerstin Westritschnig , Margarete Focke , Anna Twardosz , Peter Valent , Petra Verdino , Walter Keller , Dietrich Kraft , Rudolf Valenta
发明人： Kerstin Westritschnig , Margarete Focke , Anna Twardosz , Peter Valent , Petra Verdino , Walter Keller , Dietrich Kraft , Rudolf Valenta
IPC分类号： A01N37/18 , A61K38/00 , A61K39/00 , A61K39/35 , A61K39/36 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00
CPC分类号： C07K14/415 , A61K39/00
摘要： The present invention pertains to polypeptides derived from the timothy grass pollen allergen Phl p 7. The polypeptides display reduced allergen activity and are useful as allergy vaccines for treatment of sensitized allergic patients and for prophylactic vaccination.
摘要翻译： 本发明涉及源自Timothy草花粉变应原Ph11p7的多肽。多肽显示降低的变应原活性，并且可用作治疗致敏过敏患者和预防性接种的过敏疫苗。
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公开(公告)号：US20080286311A1
公开(公告)日：2008-11-20
申请号：US11720598
申请日：2005-12-02
CPC分类号： C07K14/415 , C12N15/62
摘要： The present invention relates to a method for producing derivatives of wild-type protein allergens with reduced allergenic activity, characterized in by the following steps: providing a wild-type protein allergen with an allergenic activity, splicing said wild-type protein allergen into two parts, said two parts having a reduced allergenic activity or lacking allergenic activity and rejoining said two fragments in inverse orientation; as well as allergen derivatives.
摘要翻译： 本发明涉及一种生产具有降低的变应原活性的野生型蛋白质变应原衍生物的方法，其特征在于以下步骤：提供具有变应原活性的野生型蛋白变应原，将所述野生型蛋白变应原剪接成两部分 所述两个部分具有降低的过敏活性或缺乏过敏活性，并以相反方向重新连接所述两个片段; 以及过敏原衍生物。
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6.发明申请Hypoallergenic allergy vaccines based on the timothy grass pollen allergen phl p7 失效基于Timothy草花粉过敏原ph1 p7的低过敏性过敏疫苗公开(公告)号：US20060216314A1
公开(公告)日：2006-09-28
申请号：US10529441
申请日：2003-09-25
申请人： Kerstin Westritschnig , Margarete Focke , Anna Twardosz , Peter Valent , Petra Verdino , Walter Keller , Dietrich Kraft , Rudolf Valenta
发明人： Kerstin Westritschnig , Margarete Focke , Anna Twardosz , Peter Valent , Petra Verdino , Walter Keller , Dietrich Kraft , Rudolf Valenta
IPC分类号： A61K39/35 , C07H21/04 , C07K14/415 , C12N5/04
CPC分类号： C07K14/415 , A61K39/00
摘要： The present invention pertains to polypeptides derived from the timothy grass pollen allergen Phi p 7. The polypeptides display reduced allergen activity and are useful as allergy vaccines for treatment of sensitized allergic patients and for prophylactic vaccination.
摘要翻译： 本发明涉及源自Timothy草花粉变应原Phi p7的多肽。多肽显示降低的变应原活性，并且可用作治疗致敏过敏患者和预防性接种的过敏疫苗。
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7.发明授权公开(公告)号：US09598472B2
公开(公告)日：2017-03-21
申请号：US14342565
申请日：2011-09-05
申请人： Larry R. Ellingsworth , David Flyer , Jing-Hui Tian , Steven R. Fuhrmann , Stefanie Kluepfel-Stahl , Gregory M. Glenn , Kerstin Westritschnig
发明人： Larry R. Ellingsworth , David Flyer , Jing-Hui Tian , Steven R. Fuhrmann , Stefanie Kluepfel-Stahl , Gregory M. Glenn , Kerstin Westritschnig
CPC分类号： A61K39/08 , A61K2039/53 , A61K2039/55505 , A61K2039/55544 , A61K2039/575 , C07K14/33 , C07K16/1282 , C07K2317/76 , C07K2319/00 , C07K2319/40 , C07K2319/55
摘要： This present invention provides C-TAB.G5 and C-TAB.G5.1 isolated polypeptides comprising the receptor binding domains of C. difficile toxin A and toxin B as set forth in the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 4. The C-TAB.G5 and C-TAB.G5.1 isolated polypeptides may be used to neutralize toxic effects of C. difficile toxin A and/or toxin B.
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8.发明申请ISOLATED POLYPEPTIDE OF THE TOXIN A AND TOXIN B PROTEINS OF C. DIFFICILE AND USES THEREOF 有权毒素A的分离多肽和毒素B的毒素B蛋白及其用途公开(公告)号：US20150056238A1
公开(公告)日：2015-02-26
申请号：US14342565
申请日：2011-09-05
申请人： Larry R. Ellingsworth , David Flyer , Jing-Hui Tian , Steven R. Fuhrmann , Stefanie Kluepfel-Stahl , Gregory M. Glenn , Kerstin Westritschnig
发明人： Larry R. Ellingsworth , David Flyer , Jing-Hui Tian , Steven R. Fuhrmann , Stefanie Kluepfel-Stahl , Gregory M. Glenn , Kerstin Westritschnig
CPC分类号： A61K39/08 , A61K2039/53 , A61K2039/55505 , A61K2039/55544 , A61K2039/575 , C07K14/33 , C07K16/1282 , C07K2317/76 , C07K2319/00 , C07K2319/40 , C07K2319/55
摘要： This present invention provides C-TAB.G5 and C-TAB.G5.1 isolated polypeptides comprising the receptor binding domains of C. difficile toxin A and toxin B as set forth in the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 4. The C-TAB.G5 and C-TAB.G5.1 isolated polypeptides may be used to neutralize toxic effects of C. difficile toxin A and/or toxin B.
摘要翻译： 本发明提供了包含艰巨梭菌毒素A和毒素B的受体结合结构域的C-TAB.G5和C-TAB.G5.1分离的多肽，如SEQ ID NO：2和SEQ ID NO：2的氨基酸序列所示 NO：4.C-TAB.G5和C-TAB.G5.1分离的多肽可用于中和艰难梭菌毒素A和/或毒素B的毒性作用。
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