公开(公告)号：US20070215891A1

公开(公告)日：2007-09-20

申请号：US11418622

申请日：2006-05-04

申请人： Russell Dahl ,  Joseph Partlow ,  Stephen Proulx

发明人： Russell Dahl ,  Joseph Partlow ,  Stephen Proulx

IPC分类号： H01L33/00

CPC分类号： H01L25/0753 ,  H01L33/60 ,  H01L2924/0002 ,  H01L2924/00

摘要： A light emitting diode (LED) array with beam directors outputting a high-intensity collimated beam. The LED array is constructed from a substrate component on which the LEDs and necessary electronics are disposed and a director attachment having a plurality of beam directors. The beam directors have a unique structure that is designed to shape the light beam into a collimated form. The LEDs are arranged in a pattern on the substrate, and the beam directors are arranged within the director attachment to coincide with the LEDs. The substrate and the director attachment may be manufactured and processed as separate components; they are then affixed together for operation.

摘要翻译： 一种发光二极管（LED）阵列，其具有输出高强度准直光束的光束指向器。 LED阵列由其上布置有LED和必要的电子设备的基板部件和具有多个光束引导件的引导器附件构成。 光束导向器具有独特的结构，其被设计成将光束成形为准直的形式。 LED以衬底上的图案布置，并且光​​束指向器布置在引导器附件内以与LED重合。 基板和引导件附件可以作为单独的部件被制造和处理; 然后将它们固定在一起进行操作。

公开(公告)号：US11213701B2

公开(公告)日：2022-01-04

申请号：US16699679

申请日：2019-12-01

申请人： Russell Dahl

发明人： Russell Dahl

IPC分类号： A61P25/28 ,  C07D215/40 ,  C07D401/04 ,  C07D401/12

摘要： Disclosed herein are methods and compositions comprising compounds capable of activating and increasing protein SUMOylation. Disclosed herein are methods and compositions comprising compounds capable of showing neuroprotective and cytoprotective effects when administered to injured cells. Also disclosed are methods comprising these compounds for treating neuronal or neurological disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, fronto-temporal dementia, chronic traumatic encepholopathy, traumatic brain injury, or stroke.

公开(公告)号：US10383867B2

公开(公告)日：2019-08-20

申请号：US15361482

申请日：2016-11-27

申请人： Russell Dahl

发明人： Russell Dahl

IPC分类号： A61K31/4709 ,  A61K31/47 ,  C07D215/14 ,  C07D215/12

摘要： Provided herein are quinolines, e.g., a compound of Formula I, pharmaceutical compositions thereof, and methods of their use for treating, preventing, or ameliorating one or more symptoms of an endoplasmic reticulum stress-caused disease. Also provided herein are methods of their use for reducing endoplasmic reticulum stress and modulating the activity of a sarcoplasmic/endoplasmic reticulum Ca2+ ATPase.

公开(公告)号：US07888355B2

公开(公告)日：2011-02-15

申请号：US12854730

申请日：2010-08-11

申请人： Ze′ev A. Ronai ,  Anindita Bhoumik ,  Nicholas D. P. Cosford ,  Russell Dahl

发明人： Ze′ev A. Ronai ,  Anindita Bhoumik ,  Nicholas D. P. Cosford ,  Russell Dahl

IPC分类号： A61K31/40 ,  A61K31/4406 ,  A61K31/215 ,  A61K31/165 ,  A61K31/16 ,  A61K31/5375 ,  A61K31/495 ,  C07D265/30 ,  C07D241/04 ,  C07D211/00 ,  C07D207/04

CPC分类号： C07C235/82 ,  C07C2603/52 ,  C07J63/008

摘要： There are provided methods of inhibiting growth and metastasis of melanoma, methods of sensitizing melanoma cells to apoptosis, and methods of treating a subject having melanoma using acetyl isogambogic acid, celastrol, or a derivative thereof. There are further provided derivatives of celastrol and compositions comprising acetyl isogambogic acid, celastrol, or a derivative thereof.

摘要翻译： 提供了抑制黑素瘤生长和转移的方法，使黑素瘤细胞对凋亡敏感的方法，以及使用乙酰基异烟酸，celastrol或其衍生物治疗患有黑素瘤的受试者的方法。 还提供了celastrol的衍生物和包含乙酰基异烟酸，celastrol或其衍生物的组合物。

公开(公告)号：US20210269404A1

公开(公告)日：2021-09-02

申请号：US17326257

申请日：2021-05-20

申请人： Russell Dahl

发明人： Russell Dahl

IPC分类号： C07D215/40 ,  C07D405/12 ,  C07D409/12

摘要： Provided herein are compounds of Formula I, pharmaceutical compositions thereof, and methods of their use for treating, preventing, or ameliorating one or more symptoms of a neurological disease, neurodegenerative disorder, or diabetes.

公开(公告)号：US10730843B1

公开(公告)日：2020-08-04

申请号：US16446644

申请日：2019-06-20

申请人： Russell Dahl

发明人： Russell Dahl

IPC分类号： A61K31/498 ,  C07D241/40 ,  C07D403/12 ,  C07D409/12 ,  C07D241/44

摘要： Provided herein are compounds of Formula I, pharmaceutical compositions thereof, and methods of their use for treating, preventing, or ameliorating one or more symptoms of a neurological disease, neurodegenerative disorder, or diabetes.

公开(公告)号：US20190375741A1

公开(公告)日：2019-12-12

申请号：US16436846

申请日：2019-06-10

申请人： Russell Dahl

发明人： Russell Dahl

IPC分类号： C07D413/14 ,  C07D413/10

摘要： Provided herein are compounds of Formula I, pharmaceutical compositions thereof, and methods of their use for treating, preventing, or ameliorating one or more symptoms of a neurological disease, neurodegenerative disorder, or diabetes.

公开(公告)号：US20190375737A1

公开(公告)日：2019-12-12

申请号：US16436843

申请日：2019-06-10

申请人： Russell Dahl

发明人： Russell Dahl

IPC分类号： C07D409/06 ,  C07D215/06 ,  A61P3/10 ,  C07D215/14

摘要： Provided herein are compounds of Formula I, pharmaceutical compositions thereof, and methods of their use for treating, preventing, or ameliorating one or more symptoms of a neurological disease, neurodegenerative disorder, or diabetes.

公开(公告)号：US20100273797A1

公开(公告)日：2010-10-28

申请号：US12829701

申请日：2010-07-02

申请人： Erik Boman ,  Susana Conde Ceide ,  Russell Dahl ,  Nancy G. J. Delaet ,  Justin Ernst ,  Antonio Garrido Montalban ,  Jeffrey Kahl ,  Christopher Larson ,  Stephen Miller ,  Hiroshi Nakanishi ,  Edward Roberts ,  Eddine Saiah ,  Robert Sullivan ,  Zhijun Wang

发明人： Erik Boman ,  Susana Conde Ceide ,  Russell Dahl ,  Nancy G. J. Delaet ,  Justin Ernst ,  Antonio Garrido Montalban ,  Jeffrey Kahl ,  Christopher Larson ,  Stephen Miller ,  Hiroshi Nakanishi ,  Edward Roberts ,  Eddine Saiah ,  Robert Sullivan ,  Zhijun Wang

IPC分类号： A61K31/5377 ,  A61K31/5375 ,  A61K31/437 ,  A61P9/00 ,  A61P19/02 ,  A61P1/00 ,  A61P29/00 ,  A61P37/06 ,  A61P25/00 ,  A61P25/28 ,  A61P3/04 ,  A61P17/00

CPC分类号： A61K31/416 ,  C07D207/40 ,  C07D231/12 ,  C07D231/40 ,  C07D239/47 ,  C07D249/12 ,  C07D253/075 ,  C07D295/088 ,  C07D403/12 ,  C07D471/04 ,  C07D487/04 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/411

摘要： The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions medicated by cytokines such as arthritis.

摘要翻译： 本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。 特别地，本发明的化合物可用作抗炎剂。 还提供了用于制备这些药剂的方法及其在预防或治疗由诸如关节炎的细胞因子药物治疗的病症中的用途。

公开(公告)号：US10800766B2

公开(公告)日：2020-10-13

申请号：US16436843

申请日：2019-06-10

申请人： Russell Dahl

发明人： Russell Dahl

IPC分类号： C07D409/06 ,  C07D215/14 ,  C07D215/06 ,  A61P3/10

摘要： Provided herein are compounds of Formula I, pharmaceutical compositions thereof, and methods of their use for treating, preventing, or ameliorating one or more symptoms of a neurological disease, neurodegenerative disorder, or diabetes.