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21 条记录 (耗时 0.072 秒)

    Methods of screening for compounds which bind G protein-coupled receptors
    1.
    发明授权
    Methods of screening for compounds which bind G protein-coupled receptors 失效
    筛选结合G蛋白偶联受体的化合物的方法

    公开(公告)号：US07927821B2

    公开(公告)日：2011-04-19

    申请号：US11578325

    申请日：2005-04-11

    申请人： Ryo Fujii ,  Shoichi Okubo ,  Kazunori Nishi ,  Shuji Hinuma ,  Masaaki Mori

    发明人： Ryo Fujii ,  Shoichi Okubo ,  Kazunori Nishi ,  Shuji Hinuma ,  Masaaki Mori

    IPC分类号： G01N33/53 ,  G01N33/567 ,  G01N33/566 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00

    CPC分类号： G01N33/76 ,  A61K31/403 ,  A61K31/4155 ,  A61K31/4523 ,  A61K38/1796 ,  C07K14/705 ,  G01N2333/726

    摘要： The present invention provides a method of screening an agonist or antagonist to a G protein-coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, which comprises using the receptor protein or a salt thereof and the ligand or a salt thereof; etc. The present invention is useful for screening agents for the prevention/treatment of, e.g., leukopenia, leukemia, lymphoma, malignant tumor, ulcerative colitis, rheumatoid arthritis, inflammatory bowel disorders, tonsil disorders, collagen disease, inflammatory disease, leukocytosis, heart failure, inherited muscle disorders, muscular dystrophy, neuromuscular degenerative disease, myocardial infarction, obesity, mellitus diabetes, hyperlipemia, arteriosclerosis, metabolic syndrome, thrombocytopenia, thrombocytosis, cancer, pulmonary edema, multiple organ failure, etc.

    摘要翻译： 本发明提供筛选G蛋白偶联受体蛋白的激动剂或拮抗剂的方法，其包含与SEQ ID NO：1所示的氨基酸序列相同或基本上相同的氨基酸序列，或其盐，其包含 使用受体蛋白或其盐和配体或其盐; 本发明可用于预防/治疗例如白细胞减少症，白血病，淋巴瘤，恶性肿瘤，溃疡性结肠炎，类风湿性关节炎，炎性肠病，扁桃体病，胶原病，炎性疾病，白细胞增多症，心脏病 失败，遗传性肌肉疾病，肌营养不良症，神经肌肉退行性疾病，心肌梗死，肥胖症，糖尿病，高脂血症，动脉硬化，代谢综合征，血小板减少症，血小板增多症，癌症，肺水肿，多器官衰竭等。

    Novel Ligand of G Protein Coupled Receptor Protein and Use Thereof
    2.
    发明申请
    Novel Ligand of G Protein Coupled Receptor Protein and Use Thereof 失效
    G蛋白偶联受体蛋白的新配体及其用途

    公开(公告)号：US20080305110A1

    公开(公告)日：2008-12-11

    申请号：US11578325

    申请日：2005-04-11

    申请人： Ryo Fujii ,  Shoichi Okubo ,  Kazunori Nishi ,  Shuji Hinuma ,  Masaaki Mori

    发明人： Ryo Fujii ,  Shoichi Okubo ,  Kazunori Nishi ,  Shuji Hinuma ,  Masaaki Mori

    IPC分类号： A61K39/395 ,  G01N33/566 ,  A61K31/415 ,  A61P37/00 ,  A61K38/00 ,  A61K31/7088

    CPC分类号： G01N33/76 ,  A61K31/403 ,  A61K31/4155 ,  A61K31/4523 ,  A61K38/1796 ,  C07K14/705 ,  G01N2333/726

    摘要： The present invention provides a method of screening an agonist or antagonist to a G protein-coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, which comprises using the receptor protein or a salt thereof and the ligand or a salt thereof; etc. The present invention is useful for screening agents for the prevention/treatment of, e.g., leukopenia, leukemia, lymphoma, malignant tumor, ulcerative colitis, rheumatoid arthritis, inflammatory bowel disorders, tonsil disorders, collagen disease, inflammatory disease, leukocytosis, heart failure, inherited muscle disorders, muscular dystrophy, neuromuscular degenerative disease, myocardial infarction, obesity, mellitus diabetes, hyperlipemia, arteriosclerosis, metabolic syndrome, thrombocytopenia, thrombocytosis, cancer, pulmonary edema, multiple organ failure, etc.

    摘要翻译： 本发明提供筛选G蛋白偶联受体蛋白的激动剂或拮抗剂的方法，其包含与SEQ ID NO：1所示的氨基酸序列相同或基本上相同的氨基酸序列，或其盐，其包含 使用受体蛋白或其盐和配体或其盐; 本发明可用于预防/治疗例如白细胞减少症，白血病，淋巴瘤，恶性肿瘤，溃疡性结肠炎，类风湿性关节炎，炎性肠病，扁桃体病，胶原病，炎性疾病，白细胞增多症，心脏病 失败，遗传性肌肉疾病，肌营养不良症，神经肌肉退行性疾病，心肌梗死，肥胖症，糖尿病，高脂血症，动脉硬化，代谢综合征，血小板减少症，血小板增多症，癌症，肺水肿，多器官衰竭等。

    Novel method of screening
    4.
    发明申请
    Novel method of screening 有权
    新型筛选方法

    公开(公告)号：US20070117160A1

    公开(公告)日：2007-05-24

    申请号：US11587285

    申请日：2005-04-22

    申请人： Ryo Fujii ,  Kazunori Nishi ,  Yasuhiro Tanaka ,  Masaaki Mori

    发明人： Ryo Fujii ,  Kazunori Nishi ,  Yasuhiro Tanaka ,  Masaaki Mori

    IPC分类号： G01N33/567 ,  G01N33/53

    CPC分类号： G01N33/566 ,  G01N2333/726 ,  G01N2500/00 ,  Y10S435/975

    摘要： The present invention relates to screening of an agonist/antagonist, etc. Specifically, the present invention provides a method of screening an agonist or antagonist of a G protein-coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, which comprises using the receptor protein or a salt thereof and a cholesterol metabolism-related substance, and so on.

    摘要翻译： 本发明涉及激动剂/拮抗剂等的筛选。具体而言，本发明提供筛选G蛋白偶联受体蛋白的激动剂或拮抗剂的方法，其包含与氨基酸相同或基本上相同的氨基酸序列 由SEQ ID NO：1表示的序列或其盐，其包括使用受体蛋白质或其盐和胆固醇代谢相关物质等。

    Insulin/IGF/relaxin family polypeptides and DNAS thereof
    7.
    发明授权
    Insulin/IGF/relaxin family polypeptides and DNAS thereof 失效
    胰岛素/ IGF /松弛素家族多肽及其DNAS

    公开(公告)号：US07049403B2

    公开(公告)日：2006-05-23

    申请号：US10257848

    申请日：2001-04-20

    申请人： Yasuaki Itoh ,  Nobuhiro Suzuki ,  Kazunori Nishi ,  Hideki Kizawa ,  Masataka Harada ,  Kazuhiro Ogi

    发明人： Yasuaki Itoh ,  Nobuhiro Suzuki ,  Kazunori Nishi ,  Hideki Kizawa ,  Masataka Harada ,  Kazuhiro Ogi

    IPC分类号： C07K14/00 ,  A01N37/18 ,  A61K39/00

    CPC分类号： G01N33/74 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K39/00 ,  C07K14/575 ,  C07K14/64 ,  C07K14/65 ,  C07K16/26 ,  G01N2333/62 ,  G01N2333/64

    摘要： The present invention relates to (1) a polypeptide containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:7 (A chain), (2) a polypeptide containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:8 (B chain), (3) a polypeptide wherein the A and B chains are bonded to each other via disulfide bonds (2 chains) or its salt, (4) DNAs encoding the same, etc.These polypeptides and DNAs encoding the same can be used for the diagnosis, treatment, prevention, etc. for diseases, including abnormalities (e.g., diabetes mellitus, etc.) in metabolic regulation (sugar metabolism, lipid metabolism, etc.) of energy sources such as carbohydrates.

    摘要翻译： 本发明涉及（1）含有与SEQ ID NO：7（A链）所示氨基酸序列相同或基本相同的氨基酸序列的多肽，（2）含有相同或基本相同氨基的多肽 酸序列作为由SEQ ID NO：8（B链）表示的氨基酸序列，（3）其中A和B链通过二硫键（2链）或其盐彼此键合的多肽，（4）DNA 编码相同的这些多肽和DNA可用于诊断，治疗，预防等疾病，包括代谢调节异常（如糖尿病等）（糖代谢，脂质代谢， 等等）的能源，如碳水化合物。

    Glutamine:fructose-6-phosphate amidotransferase, its production and use
    8.
    发明授权
    Glutamine:fructose-6-phosphate amidotransferase, its production and use 失效
    谷氨酰胺：果糖-6-磷酸酰胺转移酶，其生产和应用

    公开(公告)号：US06207431B1

    公开(公告)日：2001-03-27

    申请号：US09182983

    申请日：1998-10-30

    申请人： Kazunori Nishi ,  Yukiko Hikichi ,  Yasushi Shintani

    发明人： Kazunori Nishi ,  Yukiko Hikichi ,  Yasushi Shintani

    IPC分类号： C12N910

    CPC分类号： C12N9/1096 ,  A61K38/00 ,  C12Q1/48

    摘要： This invention relates to glutamine:fructose-6-phosphate amidotransferase, or its partial peptide or a salt thereof; a DNA coding for the protein; a recombinant vector; a transformant; a method for producing the protein; a pharmaceutical composition comprising the protein, its partial peptide or a salt thereof; and an antibody against the protein or its partial peptide. The protein, its partial peptide or a salt thereof, and the DNA are useful for a prophylactic or therapeutic agent for hypoglycemia. The antibody can be used in the assay of the protein, its partial peptide or a salt thereof. The protein, its partial peptide or a salt thereof is useful as a reagent for the screening for candidate medical compounds.

    摘要翻译： 本发明涉及谷氨酰胺：果糖-6-磷酸酰胺转移酶或其部分肽或其盐; 编码蛋白质的DNA; 重组载体; 转化子 一种生产蛋白质的方法; 包含蛋白质，其部分肽或其盐的药物组合物; 和针对蛋白质或其部分肽的抗体。 蛋白质，其部分肽或其盐和DNA可用于低血糖症的预防或治疗剂。 该抗体可用于蛋白质，其部分肽或其盐的测定。 蛋白质，其部分肽或其盐可用作候选药物化合物的筛选试剂。

    Human CRM1 Protein
    9.
    发明授权
    Human CRM1 Protein 失效
    人类CRM1蛋白

    公开(公告)号：US5948883A

    公开(公告)日：1999-09-07

    申请号：US975527

    申请日：1997-11-20

    申请人： Minoru Yoshida ,  Sueharu Horinouchi ,  Kazunori Nishi

    发明人： Minoru Yoshida ,  Sueharu Horinouchi ,  Kazunori Nishi

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N15/12

    CPC分类号： C07K14/4703 ,  A61K38/00

    摘要： A protein which comprises the sane or substantially the same amino acid sequence as that represented by SEQ ID NO:1, its partial peptide and their salts are disclosed. DNA encoding the protein or its partial peptide is also disclosed. The protein, its partial peptide or a salt thereof is an inhibitory factor of a transcription factor and, therefore, it is useful as medicine such as prophylactic and therapeutic drugs of, for example, tumors. The DNA is useful as a gene diagnosing drug. The antibody against the protein, etc. is also disclosed. The antibody is used for, for example, quantitative determination of the protein, etc. in a specimen fluid. The protein, etc. are also useful as a reagent for screening for compounds or their salts which promote the function of the protein, etc.

    摘要翻译： 公开了包含与SEQ ID NO：1所示的基本相同的氨基酸序列的蛋白质，其部分肽及其盐。 还公开了编码蛋白质或其部分肽的DNA。 蛋白质，其部分肽或其盐是转录因子的抑制因子，因此可用作例如肿瘤的预防和治疗药物等药物。 该DNA可用作诊断药物的基因。 还公开了针对蛋白质等的抗体。 抗体用于例如样品流体中蛋白质等的定量测定。 蛋白质等也可用作筛选促进蛋白质等功能的化合物或其盐的试剂。

    Screening method
    10.
    发明授权
    Screening method 失效
    筛选方法

    公开(公告)号：US07892755B2

    公开(公告)日：2011-02-22

    申请号：US11661555

    申请日：2005-08-29

    申请人： Yasuaki Ito ,  Kazunori Nishi ,  Shoichi Ohkubo ,  Masataka Harada

    发明人： Yasuaki Ito ,  Kazunori Nishi ,  Shoichi Ohkubo ,  Masataka Harada

    IPC分类号： G01N33/566 ,  A61K38/00

    CPC分类号： G01N33/6893 ,  C07K14/705 ,  G01N33/574 ,  G01N2500/00

    摘要： The present invention provides a method of screening a compound or its salt that alters binding properties of a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, and a ligand capable of specifically binding to the protein or its salt, which comprises using (a) the protein, its partial peptide, or a salt thereof and (b) the ligand; a screening kit therefor, and so on. The screening method and kit of the present invention are useful for screening an agent for the prevention/treatment of, e.g., digestive tract disorders, cancer, immune disorders, type II diabetes mellitus or obesity, etc.

    摘要翻译： 本发明提供一种筛选化合物或其盐的方法，其改变包含与SEQ ID NO：1所示的氨基酸序列相同或基本上相同的氨基酸序列的蛋白质的结合性，或其盐，和 能够特异性结合蛋白质或其盐的配体，其包括使用（a）蛋白质，其部分肽或其盐和（b）配体; 一个筛选工具，等等。 本发明的筛选方法和试剂盒可用于筛选用于预防/治疗例如消化道疾病，癌症，免疫疾病，II型糖尿病或肥胖症等的药剂。