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1.发明授权公开(公告)号：US06207431B1
公开(公告)日：2001-03-27
申请号：US09182983
申请日：1998-10-30
申请人： Kazunori Nishi , Yukiko Hikichi , Yasushi Shintani
发明人： Kazunori Nishi , Yukiko Hikichi , Yasushi Shintani
IPC分类号： C12N910
CPC分类号： C12N9/1096 , A61K38/00 , C12Q1/48
摘要： This invention relates to glutamine:fructose-6-phosphate amidotransferase, or its partial peptide or a salt thereof; a DNA coding for the protein; a recombinant vector; a transformant; a method for producing the protein; a pharmaceutical composition comprising the protein, its partial peptide or a salt thereof; and an antibody against the protein or its partial peptide. The protein, its partial peptide or a salt thereof, and the DNA are useful for a prophylactic or therapeutic agent for hypoglycemia. The antibody can be used in the assay of the protein, its partial peptide or a salt thereof. The protein, its partial peptide or a salt thereof is useful as a reagent for the screening for candidate medical compounds.
摘要翻译： 本发明涉及谷氨酰胺：果糖-6-磷酸酰胺转移酶或其部分肽或其盐; 编码蛋白质的DNA; 重组载体; 转化子 一种生产蛋白质的方法; 包含蛋白质，其部分肽或其盐的药物组合物; 和针对蛋白质或其部分肽的抗体。 蛋白质，其部分肽或其盐和DNA可用于低血糖症的预防或治疗剂。 该抗体可用于蛋白质，其部分肽或其盐的测定。 蛋白质，其部分肽或其盐可用作候选药物化合物的筛选试剂。
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2.发明授权Glutamine: fructose-6-phosphate amidotransferase, its production and use 失效谷氨酰胺：果糖-6-磷酸酰胺转移酶，其生产和使用公开(公告)号：US06632627B2
公开(公告)日：2003-10-14
申请号：US09771838
申请日：2001-01-29
申请人： Kazunori Nishi , Yukiko Hikichi , Yasushi Shintani
发明人： Kazunori Nishi , Yukiko Hikichi , Yasushi Shintani
IPC分类号： C12N910
CPC分类号： A61K38/45 , A01K2217/075 , A61K48/00 , C12N9/1096
摘要： This invention relates to glutamine:fructose-6-phosphate amidotransferase, or its partial peptide or a salt thereof; a DNA coding for the protein; a recombinant vector; a transformant; a method for producing the protein; a pharmaceutical composition comprising the protein, its partial peptide or a salt thereof; and an antibody against the protein or its partial peptide. The protein, its partial peptide or a salt thereof, and the DNA are useful for a prophylactic or therapeutic agent for hypoglycemia. The antibody can be used in the assay of the protein, its partial peptide or a salt thereof. The protein, its partial peptide or a salt thereof is useful as a reagent for the screening for candidate medical compounds.
摘要翻译： 本发明涉及谷氨酰胺：果糖-6-磷酸酰胺转移酶或其部分肽或其盐; 编码蛋白质的DNA; 重组载体; 转化子 一种生产蛋白质的方法; 包含蛋白质，其部分肽或其盐的药物组合物; 和针对蛋白质或其部分肽的抗体。 蛋白质，其部分肽或其盐和DNA可用于低血糖症的预防或治疗剂。 该抗体可用于蛋白质，其部分肽或其盐的测定。 蛋白质，其部分肽或其盐可用作候选药物化合物的筛选试剂
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公开(公告)号：US06590090B1
公开(公告)日：2003-07-08
申请号：US09653285
申请日：2000-08-31
申请人： Kazunori Nishi , Yukiko Hikichi , Yasushi Shintani
发明人： Kazunori Nishi , Yukiko Hikichi , Yasushi Shintani
IPC分类号： C07A2104
CPC分类号： C07K14/705 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K14/4747
摘要： This invention relates to a Fas ligand-like protein having an apotosis-inducing actibvity, etc. or its salt, a partial peptide of the protein or its salt; a DNA coding for the protein; a recombinant vector; a transformant; a method for producing the protein, a pharmaceutical composition comprising the protein, the partial peptide or its salt; and an antibody to the protein or the partial peptide. The protein, the partial peptide or its salt, and the DNA are useful as a prophylactic or therapeutic agent for cancer, viral infection, Helicobacter pylori infection, invasive staphylococcia, hepatitis, nephritis, bone disease, atherosclerosis or pain. The antibody can be used in assay of the protein, the partial peptide or its salt. The protein, the partial peptide or its salt is useful as a reagent for the screening for candidate medical compounds.
摘要翻译： 本发明涉及具有诱导凋亡活性等的其它Fas配体样蛋白质或其盐，蛋白质或其盐的部分肽; 编码蛋白质的DNA; 重组载体; 转化子 一种生产蛋白质的方法，包含该蛋白质，部分肽或其盐的药物组合物; 和对蛋白质或部分肽的抗体。 蛋白质，部分肽或其盐和DNA可用作癌症，病毒感染，幽门螺杆菌感染，侵入性葡萄球菌，肝炎，肾炎，骨病，动脉粥样硬化或疼痛的预防或治疗剂。 该抗体可用于测定蛋白质，部分肽或其盐。 蛋白质，部分肽或其盐可用作候选药物化合物的筛选试剂。
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公开(公告)号：US06235878B1
公开(公告)日：2001-05-22
申请号：US08913014
申请日：1997-09-04
申请人： Kazunori Nishi , Yukiko Hikichi , Yasushi Shintani
发明人： Kazunori Nishi , Yukiko Hikichi , Yasushi Shintani
IPC分类号： C07K100
CPC分类号： C07K14/705 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K14/4747
摘要： This invention is directed toward novel human and murine Fas ligand-like proteins having an apoptosis-inducing activity. Cloned cDNAs encoding human, mouse, and rat Fas ligand-like proteins were obtained from human liver, mouse embryo, and rat liver cDNA libraries. The cDNAs were expressed in a recombinant yeast (e.g., Pichia) expression system. The expressed proteins should prove useful in a number of biochemical and immunological applications.
摘要翻译： 本发明针对具有凋亡诱导活性的新型人和鼠Fas配体样蛋白。 从人肝，小鼠胚胎和大鼠肝cDNA文库获得编码人，小鼠和大鼠Fas配体样蛋白的克隆cDNA。 cDNA在重组酵母（例如毕赤酵母）表达系统中表达。 表达的蛋白质应证明在许多生化和免疫应用中是有用的。
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5.发明授权Glutamine: fructose-6-phosphate amidotransferase, its production and use 失效谷氨酰胺：果糖-6-磷酸酰胺转移酶，其生产和使用
公开(公告)号：US5876713A
公开(公告)日：1999-03-02
申请号：US911445
申请日：1997-08-12
申请人： Kazunori Nishi , Yukiko Hikichi , Yasushi Shintani
发明人： Kazunori Nishi , Yukiko Hikichi , Yasushi Shintani
CPC分类号： C12N9/1096 , C12Q1/48 , A61K38/00
摘要： This invention relates to glutamine:fructose-6-phosphate amidotransferase, or its partial peptide or a salt thereof; a DNA coding for the protein; a recombinant vector; a transformant; a method for producing the protein; a pharmaceutical composition comprising the protein, its partial peptide or a salt thereof; and an antibody against the protein or its partial peptide. The protein, its partial peptide or a salt thereof, and the DNA are useful for a prophylactic or therapeutic agent for hypoglycemia. The antibody can be used in the assay of the protein, its partial peptide or a salt thereof. The protein, its partial peptide or a salt thereof is useful as a reagent for the screening for candidate medical compounds.
摘要翻译： 本发明涉及谷氨酰胺：果糖-6-磷酸酰胺转移酶或其部分肽或其盐; 编码蛋白质的DNA; 重组载体; 转化子 一种生产蛋白质的方法; 包含蛋白质，其部分肽或其盐的药物组合物; 和针对蛋白质或其部分肽的抗体。 蛋白质，其部分肽或其盐和DNA可用于低血糖症的预防或治疗剂。 该抗体可用于蛋白质，其部分肽或其盐的测定。 蛋白质，其部分肽或其盐可用作候选药物化合物的筛选试剂。
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公开(公告)号：US6068990A
公开(公告)日：2000-05-30
申请号：US157349
申请日：1998-09-18
CPC分类号： C12N9/6472 , A61K48/00
摘要： This invention relates to a novel calpain having a proteolytic activity, its partial peptide or a salt either of them, a DNA coding for the protein, a recombinant vector comprising the DNA, a transformant carrying the recombinant vector, a process for producing the protein, a pharmaceutical composition comprising the DNA, an antibody against the protein, a method for screening for a compound which activates or inhibits a proteolytic activity of the protein, a kit for screening for the compound, and a compound which activates or inhibits a proteolytic activity of the protein which is identified by the screening method or the kit. The DNA coding for the protein of the present invention can be used as a therapeutic and prophylactic composition for a variety of diseases including tumor, cerebral apoplexy, cerebral infarction, subarachnoid hemorrhage, Alzheimer's disease, myodystrophy, cataract, ischemic heart disease, atherosclerosis, arthritis, and collagen disease. Furthermore, the protein of the present invention is useful as a screening reagent for any compounds which activates or inhibits the function of the protein of the present invention. In addition, the antibody against the protein of the present invention specifically recognizes the protein of the present invention and can be used in the quantitative determination of the protein of the present invention in a test fluid.
摘要翻译： 本发明涉及具有蛋白水解活性的新型钙蛋白酶，其部分肽或其任意一种的盐，编码该蛋白质的DNA，包含该DNA的重组载体，携带该重组载体的转化体，该蛋白质的制备方法， 包含DNA，抗蛋白质的抗体的药物组合物，用于筛选活化或抑制蛋白质的蛋白水解活性的化合物的方法，用于筛选化合物的试剂盒，以及激活或抑制蛋白质的蛋白水解活性的化合物 通过筛选方法或试剂盒鉴定的蛋白质。 编码本发明的蛋白质的DNA可以用作各种疾病的治疗和预防组合物，包括肿瘤，脑中风，脑梗塞，蛛网膜下腔出血，阿尔茨海默病，肌营养不良，白内障，缺血性心脏病，动脉粥样硬化，关节炎 和胶原病。 此外，本发明的蛋白质可用作活化或抑制本发明的蛋白质的功能的任何化合物的筛选试剂。 此外，针对本发明的蛋白质的抗体特异性地识别本发明的蛋白质，并且可以用于在测试流体中定量测定本发明的蛋白质。
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公开(公告)号：US5874277A
公开(公告)日：1999-02-23
申请号：US835099
申请日：1997-04-04
CPC分类号： C12N9/6472 , A61K48/00
摘要： This invention relates to a novel calpain having a proteolytic activity, its partial peptide or a salt either of them, a DNA coding for the protein, a recombinant vector comprising the DNA, a transformant carrying the recombinant vector, a process for producing the protein, a pharmaceutical composition comprising the DNA, an antibody against the protein, a method for screening for a compound which activates or inhibits a proteolytic activity of the protein, a kit for screening for the compound, and a compound which activates or inhibits a proteolytic activity of the protein which is identified by the screening method or the kit. The DNA coding for the protein of the present invention can be used as a therapeutic and prophylactic composition for a variety of diseases including tumor, cerebral apoplexy, cerebral infarction, subarachnoid hemorrhage, Alzheimer's disease, myodystrophy, cataract, ischemic heart disease, atherosclerosis, arthritis, and collagen disease. Furthermore, the protein of the present invention is useful as a screening reagent for any compounds which activates or inhibits the function of the protein of the present invention. In addition, the antibody against the protein of the present invention specifically recognizes the protein of the present invention and can be used in the quantitative determination of the protein of the present invention in a test fluid.
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8.发明授权公开(公告)号：US07927821B2
公开(公告)日：2011-04-19
申请号：US11578325
申请日：2005-04-11
申请人： Ryo Fujii , Shoichi Okubo , Kazunori Nishi , Shuji Hinuma , Masaaki Mori
发明人： Ryo Fujii , Shoichi Okubo , Kazunori Nishi , Shuji Hinuma , Masaaki Mori
IPC分类号： G01N33/53 , G01N33/567 , G01N33/566 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： G01N33/76 , A61K31/403 , A61K31/4155 , A61K31/4523 , A61K38/1796 , C07K14/705 , G01N2333/726
摘要： The present invention provides a method of screening an agonist or antagonist to a G protein-coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, which comprises using the receptor protein or a salt thereof and the ligand or a salt thereof; etc. The present invention is useful for screening agents for the prevention/treatment of, e.g., leukopenia, leukemia, lymphoma, malignant tumor, ulcerative colitis, rheumatoid arthritis, inflammatory bowel disorders, tonsil disorders, collagen disease, inflammatory disease, leukocytosis, heart failure, inherited muscle disorders, muscular dystrophy, neuromuscular degenerative disease, myocardial infarction, obesity, mellitus diabetes, hyperlipemia, arteriosclerosis, metabolic syndrome, thrombocytopenia, thrombocytosis, cancer, pulmonary edema, multiple organ failure, etc.
摘要翻译： 本发明提供筛选G蛋白偶联受体蛋白的激动剂或拮抗剂的方法，其包含与SEQ ID NO：1所示的氨基酸序列相同或基本上相同的氨基酸序列，或其盐，其包含 使用受体蛋白或其盐和配体或其盐; 本发明可用于预防/治疗例如白细胞减少症，白血病，淋巴瘤，恶性肿瘤，溃疡性结肠炎，类风湿性关节炎，炎性肠病，扁桃体病，胶原病，炎性疾病，白细胞增多症，心脏病 失败，遗传性肌肉疾病，肌营养不良症，神经肌肉退行性疾病，心肌梗死，肥胖症，糖尿病，高脂血症，动脉硬化，代谢综合征，血小板减少症，血小板增多症，癌症，肺水肿，多器官衰竭等。
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公开(公告)号：US07049403B2
公开(公告)日：2006-05-23
申请号：US10257848
申请日：2001-04-20
申请人： Yasuaki Itoh , Nobuhiro Suzuki , Kazunori Nishi , Hideki Kizawa , Masataka Harada , Kazuhiro Ogi
发明人： Yasuaki Itoh , Nobuhiro Suzuki , Kazunori Nishi , Hideki Kizawa , Masataka Harada , Kazuhiro Ogi
CPC分类号： G01N33/74 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K39/00 , C07K14/575 , C07K14/64 , C07K14/65 , C07K16/26 , G01N2333/62 , G01N2333/64
摘要： The present invention relates to (1) a polypeptide containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:7 (A chain), (2) a polypeptide containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:8 (B chain), (3) a polypeptide wherein the A and B chains are bonded to each other via disulfide bonds (2 chains) or its salt, (4) DNAs encoding the same, etc.These polypeptides and DNAs encoding the same can be used for the diagnosis, treatment, prevention, etc. for diseases, including abnormalities (e.g., diabetes mellitus, etc.) in metabolic regulation (sugar metabolism, lipid metabolism, etc.) of energy sources such as carbohydrates.
摘要翻译： 本发明涉及（1）含有与SEQ ID NO：7（A链）所示氨基酸序列相同或基本相同的氨基酸序列的多肽，（2）含有相同或基本相同氨基的多肽 酸序列作为由SEQ ID NO：8（B链）表示的氨基酸序列，（3）其中A和B链通过二硫键（2链）或其盐彼此键合的多肽，（4）DNA 编码相同的这些多肽和DNA可用于诊断，治疗，预防等疾病，包括代谢调节异常（如糖尿病等）（糖代谢，脂质代谢， 等等）的能源，如碳水化合物。
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公开(公告)号：US5948883A
公开(公告)日：1999-09-07
申请号：US975527
申请日：1997-11-20
CPC分类号： C07K14/4703 , A61K38/00
摘要： A protein which comprises the sane or substantially the same amino acid sequence as that represented by SEQ ID NO:1, its partial peptide and their salts are disclosed. DNA encoding the protein or its partial peptide is also disclosed. The protein, its partial peptide or a salt thereof is an inhibitory factor of a transcription factor and, therefore, it is useful as medicine such as prophylactic and therapeutic drugs of, for example, tumors. The DNA is useful as a gene diagnosing drug. The antibody against the protein, etc. is also disclosed. The antibody is used for, for example, quantitative determination of the protein, etc. in a specimen fluid. The protein, etc. are also useful as a reagent for screening for compounds or their salts which promote the function of the protein, etc.
摘要翻译： 公开了包含与SEQ ID NO：1所示的基本相同的氨基酸序列的蛋白质，其部分肽及其盐。 还公开了编码蛋白质或其部分肽的DNA。 蛋白质，其部分肽或其盐是转录因子的抑制因子，因此可用作例如肿瘤的预防和治疗药物等药物。 该DNA可用作诊断药物的基因。 还公开了针对蛋白质等的抗体。 抗体用于例如样品流体中蛋白质等的定量测定。 蛋白质等也可用作筛选促进蛋白质等功能的化合物或其盐的试剂。
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