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    Process for producing 7-dimethylamino-6-demethyl-6-deoxytetracycline
    2.
    发明授权
    Process for producing 7-dimethylamino-6-demethyl-6-deoxytetracycline 失效
    7-二甲基氨基-6-脱甲基-6-脱氧四环素的制备方法

    公开(公告)号：US4918208A

    公开(公告)日：1990-04-17

    申请号：US222886

    申请日：1988-07-22

    申请人： Ryoichi Hasegawa ,  Hiroaki Ohno ,  Kazuaki Sano ,  Yoshinori Saito

    发明人： Ryoichi Hasegawa ,  Hiroaki Ohno ,  Kazuaki Sano ,  Yoshinori Saito

    IPC分类号： C07C231/22 ,  C07C237/26

    CPC分类号： C07C231/22 ,  C07C237/26 ,  C07C2103/46

    摘要： A process for producing 7-dimethylamino-6-demethyl-6-deoxytetracycline (minocycline) which comprises treating the reaction liquid containing minocycline and formaldehyde with hydroxylamine or urea, the reaction liquid being obtained after reductive methylation of 7-amino-6-demethyl-6-deoxytetracycline by using aldehyde, then subjecting the reaction liquid to an adsorption treatment with a nonionic adsorption resin (adsorbent), and subsequently eluting the intended product adsorbed to the adsorbent.

    摘要翻译： 一种7-二甲基氨基-6-脱氧四环素（二甲胺四环素）的制备方法，其包括用羟胺或尿素处理含有二甲胺四环素和甲醛的反应液体，所述反应液是在还原甲基化7-氨基-6-去甲基 - 通过使用醛，然后用非离子吸附树脂（吸附剂）对反应液进行吸附处理，随后洗脱吸附在吸附剂上的预期产物。

    Azo Compound, And Dye-Containing Polarizing Film Comprising The Same
    4.
    发明申请
    Azo Compound, And Dye-Containing Polarizing Film Comprising The Same 有权
    偶氮化合物和含有染料的偏光膜包括它

    公开(公告)号：US20100226008A1

    公开(公告)日：2010-09-09

    申请号：US12739210

    申请日：2008-10-30

    申请人： Takahiro Higeta ,  Hiroaki Ohno ,  Yuichi Sadamitsu

    发明人： Takahiro Higeta ,  Hiroaki Ohno ,  Yuichi Sadamitsu

    IPC分类号： G02B5/30 ,  C07C245/10

    CPC分类号： C07D249/22 ,  C09B31/072 ,  C09B31/08 ,  C09B31/20 ,  C09B31/22 ,  C09B31/30 ,  C09B45/28 ,  C09B56/08 ,  G02B5/3025 ,  G02B5/3033

    摘要： Disclosed is an azo compound represented by the formula (1) or (2) or a salt thereof. The azo compound or the salt thereof has an excellent light-polarizing property, and is extremely useful as a dichroic dye for use in a polarizing plate that shows less color leakage in a visible light range or a polarizing plate for a liquid crystal projector comprising the aforementioned polarizing plate. (1) (2) wherein R1 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a sulfonate group or a carboxyl group; R2 to R5 independently represent a hydrogen atom, a lower alkyl group, a lower alkoxy group or an acetylamino group; X represents a benzoylamino group which may have a substituent, a phenylamino group which may have a substituent, a phenylazo group which may have a substituent, or a naphthotriazole group which may have a substituent; m represents a numeral number of 1 or 2; and n represents a numeral number of 0 or 1.

    摘要翻译： 公开了由式（1）或（2）表示的偶氮化合物或其盐。 偶氮化合物或其盐具有优异的光偏振性，并且作为用于偏光板的二色性染料非常有用，该偏光板在可见光范围内显示较少的色漏，或用于液晶投影仪的偏振片包括 上述偏振片。 （1）（2）其中R1表示氢原子，低级烷基，低级烷氧基，羟基，磺酸酯基或羧基; R2至R5独立地表示氢原子，低级烷基，低级烷氧基或乙酰氨基; X表示可以具有取代基的苯甲酰氨基，可以具有取代基的苯基氨基，可以具有取代基的苯偶氮基或可具有取代基的萘并三唑基; m表示1或2的数字; n表示数字0或1。

    Azo compound, ink composition and colored article
    5.
    发明授权
    Azo compound, ink composition and colored article 有权
    偶氮化合物，油墨组合物和有色制品

    公开(公告)号：US07503967B2

    公开(公告)日：2009-03-17

    申请号：US11666673

    申请日：2005-11-10

    申请人： Takahiko Matsui ,  Hiroaki Ohno ,  Yasuo Shirasaki

    发明人： Takahiko Matsui ,  Hiroaki Ohno ,  Yasuo Shirasaki

    IPC分类号： C09D11/02 ,  C09B35/50 ,  B41J2/01

    CPC分类号： C09D11/16 ,  C09B33/26 ,  C09D11/328 ,  D06P5/30

    摘要： An azo compound represented by the following Formula (1) or a salt thereof, and an ink composition comprising the same (wherein, each of R1, R2, R5, R6 and R7 independently represents a hydrogen atom, a carboxyl group, a sulfo group and the like, each of R3 and R4 independently represents a hydrogen atom, a sulfo group, a nitro group, a (C1 to C4) alkyl group (which may be substituted by a hydroxyl group or a (C1 to C4) alkoxy group), a (C1 to C4) alkoxy group (which may be substituted by a hydroxyl group, a (C1 to C4) alkoxy group, a sulfo group or a carboxyl group) and the like, and n represents 0 or 1, respectively).

    摘要翻译： 由下式（1）表示的偶氮化合物或其盐及其组合物（其中，R 1，R 2，R 5，R 6和R 7各自独立地表示氢原子，羧基，磺基 R 3和R 4各自独立地表示氢原子，磺基，硝基，（C 1〜C 4）烷基（可以被羟基或（C 1〜C 4）烷氧基取代） ，（C1-C4）烷氧基（其可以被羟基，（C1-C4）烷氧基，磺基或羧基取代）等，n分别表示0或1）。

    Azo compound, ink composition, and colored object
    6.
    发明授权
    Azo compound, ink composition, and colored object 有权
    偶氮化合物，油墨组合物和有色物体

    公开(公告)号：US07503965B2

    公开(公告)日：2009-03-17

    申请号：US11547302

    申请日：2005-04-06

    申请人： Takahiko Matsui ,  Hiroaki Ohno ,  Takashi Yoneda ,  Yasuo Shirasaki

    发明人： Takahiko Matsui ,  Hiroaki Ohno ,  Takashi Yoneda ,  Yasuo Shirasaki

    IPC分类号： C09D11/00 ,  C09D11/02 ,  C09B35/50 ,  B41J2/01

    CPC分类号： C07D231/46 ,  C09B35/58 ,  C09D11/17 ,  C09D11/328

    摘要： A novel azo compound represented by the following Formula (1) wherein A represents the following Formula (2) and is located preferably in a position meta or para to the azo group; R1 and R2 each independently represents hydrogen, carboxy, sulfo, nitro, C1-4 alkoxy, etc.; R3 and R4 each independently represents hydrogen, halogeno, cyano, carboxy, sulfo, nitro, C1-4 alkyl, hydroxy, or C1-4 alkoxy; and n is 0 or 1. [In the Formula (2), R5 represents cyano, carboxy, C1-4 alky, C1-4 alkoxycarbonyl, or phenyl; and R6, R7, and R8 each independently represents hydrogen, halogeno, cyano, carboxy, sulfo, nitro, C1-4 alkyl, C1-4 alkoxy, or acylamino.] The compound is useful as a black dye, especially one for ink compositions for, e.g., inkjet prints. Also provided are: an ink composition which contains the compound and has excellent storage stability; and a print obtained through recording with the ink. The print is excellent in light resistance, ozone resistance, fastness to moisture, etc.

    摘要翻译： 由下式（1）表示的新型偶氮化合物，其中A表示下式（2），优选位于偶氮基的间位或对位; R 1和R 2各自独立地表示氢，羧基，磺基，硝基，C 1-4烷氧基等。 R 3和R 4各自独立地表示氢，卤素，氰基，羧基，磺基，硝基，C 1-4烷基，羟基或C 1-4烷氧基; 并且n为0或1. [式（2）中，R 5表示氰基，羧基，C 1-4烷基，C 1-4烷氧基羰基或苯基。 并且R 6，R 7和R 8各自独立地表示氢，卤素，氰基，羧基，磺基，硝基，C 1-4烷基，C 1-4烷氧基或酰基氨基。]该化合物可用作黑色染料，特别是用于油墨组合物 例如喷墨打印。 还提供：含有该化合物并具有优异储存稳定性的油墨组合物; 以及通过用墨水记录获得的印刷品。 该印刷品的耐光性，耐臭氧性，耐潮湿性等优异。

    Trisazo compound, ink composition, and colored object
    8.
    发明申请
    Trisazo compound, ink composition, and colored object 失效
    三唑烷化合物，油墨组合物和有色物体

    公开(公告)号：US20070107628A1

    公开(公告)日：2007-05-17

    申请号：US10581469

    申请日：2004-11-26

    申请人： Takahiko Matsui ,  Hiroaki Ohno ,  Takashi Yoneda ,  Yoshiaki Kawaida ,  Yasuo Shirasaki

    发明人： Takahiko Matsui ,  Hiroaki Ohno ,  Takashi Yoneda ,  Yoshiaki Kawaida ,  Yasuo Shirasaki

    IPC分类号： C09D11/00 ,  C09D11/02 ,  C07C245/02

    CPC分类号： C09D11/328 ,  C09B33/22

    摘要： [PROBLEMS] To provide: a black compound which is for use in ink-jet recording or writing utensils, is excellent in ozone resistance, light resistance, moisture resistance, and color rendering, and gives a recording fluid having satisfactory storage stability; and an ink composition containing the compound. [MEANS FOR SOLVING PROBLEMS] The black compound is a trisazo compound represented by the following formula (1) or a salt thereof. (1) [In the formula (1), R1 and R2 each independently represents hydrogen, carboxy, sulfo, hydroxy, a C1-4 alkyl, C1-4 alkoxy, or sulfo group optionally substituted by C1-4 alkoxy, an optionally carboxylated C1-4 alkoxy group, etc.; and A represents phenyl or naphthyl (provided that the phenyl and naphthyl groups may be substituted by halogeno, carboxy, sulfo, sulfamonyl optionally substituted by alkyl or phenyl, nitro, etc.).]

    摘要翻译： 提供：用于喷墨记录或书写用具的黑色化合物，具有优异的耐臭氧性，耐光性，耐湿性和显色性，并且得到具有令人满意的储存稳定性的记录液; 和含有该化合物的油墨组合物。 解决问题的方法黑色化合物是由下式（1）表示的三偶氮化合物或其盐。 （1）[式（1）中，R 1和R 2各自独立地表示氢，羧基，磺基，羟基，C 1-4烷基， C 1-4烷氧基或任选被C 1-4烷氧基取代的磺基，任选羧基化的C 1-4烷基 烷氧基等。 并且A表示苯基或萘基（条件是苯基和萘基可以被卤素，羧基，磺基，任选被烷基或苯基，硝基等取代的磺酰氨基取代）。

    Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of macrophage colony stimulating factor receptor
    9.
    发明申请
    Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of macrophage colony stimulating factor receptor 失效
    喹啉衍生物和喹唑啉衍生物抑制巨噬细胞集落刺激因子受体的自磷酸化

    公开(公告)号：US20060235033A1

    公开(公告)日：2006-10-19

    申请号：US10510961

    申请日：2003-05-01

    申请人： Kazuo Kubo ,  Hiroaki Ohno ,  Toshiyuki Isoe ,  Tsuyoshi Nishitoba

    发明人： Kazuo Kubo ,  Hiroaki Ohno ,  Toshiyuki Isoe ,  Tsuyoshi Nishitoba

    IPC分类号： A61K31/517 ,  A61K31/4704 ,  C07D239/88

    CPC分类号： C07D215/233 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/5377 ,  C07D417/12

    摘要： An objective of the present invention is to provide compounds which have inhibitory activity against autophosphorylation of macrophage colony-stimulating factor receptors. The compounds of the present invention are represented by formula (I) and salt and solvate thereof: wherein X represents CH or N; Z represents O or S; R1, R2, and R3 represent H, optionally substituted alkoxy or the like; R4 represents H; R5, R6, R7, and R8 represent H, halogen, alkyl, alkoxy, trifluoromethyl or the like; R9 and R10 represent H, alkyl or the like; and any one of R11 and R12 represents H with the other representing alkyl and R13 represents an optionally substituted carbocyclic or heterocyclic ring or the like, or R11 represents H and R12 and R13 combine together to form a bicyclic carbocyclic ring.

    摘要翻译： 本发明的目的是提供对巨噬细胞集落刺激因子受体的自磷酸化具有抑制活性的化合物。 本发明的化合物由式（I）表示，其盐和溶剂化物：其中X表示CH或N; Z表示O或S; R 1，R 2，R 3和R 3代表H，任选取代的烷氧基等; R 4表示H; R 5，R 6，R 7和R 8表示H，卤素，烷基，烷氧基，三氟甲基 或类似物; R 9和R 10代表H，烷基等; 并且R 11和R 12中的任何一个代表H，另一个代表烷基，R 13表示任选取代的碳环或杂环或 或者R 11表示H并且R 12和R 13结合在一起以形成双环碳环。

    2-acylamino-5-halogenated-cinnamic acid derivative and method for its production
    10.
    发明授权
    2-acylamino-5-halogenated-cinnamic acid derivative and method for its production 失效
    2-酰基氨基-5-卤代肉桂酸衍生物及其制备方法

    公开(公告)号：US4997972A

    公开(公告)日：1991-03-05

    申请号：US450832

    申请日：1989-12-14

    申请人： Hiroaki Ohno ,  Daisaku Matsunaga

    发明人： Hiroaki Ohno ,  Daisaku Matsunaga

    IPC分类号： C07C237/22

    CPC分类号： C07C237/22

    摘要： A 2-acylamino-5-halogenated-cinnamic acid derivative represented by the formula (III) which is useful as an intermediate for producing medicines and agricultural chemicals: ##STR1## wherein Ac represents a lower acyl group, R represents a hydrogen atom or a lower alkyl group, and X.sub.1 represents a halogen atom. This derivative is obtained by reacting a compound represented by the formula (I), ##STR2## wherein Ac and X.sub.1 are as defined above, and X.sub.2 represents a bromine or iodine atom, with acrylic acid or its ester represented by the formula (II),CH.sub.2 .dbd.CHCOOR (II)where R is as defined above, in the presence of a palladium catalyst, a tri(unsubstituted- or substituted-phenyl)phosphine and an acid-binding agent.