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公开(公告)号:US20050067285A1
公开(公告)日:2005-03-31
申请号:US10913517
申请日:2004-08-09
申请人: Ryoji Inaba , Miho Ozawa , Akihiro Suzuki , Daizo Tokinaga , Tomohiro Shoji , Yoshitaka Kodama , Isao Haraura , Masaya Kojima
发明人: Ryoji Inaba , Miho Ozawa , Akihiro Suzuki , Daizo Tokinaga , Tomohiro Shoji , Yoshitaka Kodama , Isao Haraura , Masaya Kojima
IPC分类号: G01N21/64 , G01N27/447 , G01N27/453
CPC分类号: G01N27/44782 , G01N27/44721
摘要: The present invention is related to the decrease of crosstalk, in which part of light emission from a specific capillary is overlayed on the light emission position of its adjoining capillaries and is detected as signal from adjacent capillaries. Study conducted by the inventor has found that the crosstalk contains at least the following components. The signal light from a capillary may propagate through an adjoining capillary or a plurality of capillaries, the reflection at the inner surface of the outer diameter of quartz capillary makes plural signal paths to the photodetector. The crosstalk component may be focused at a point at a predetermined distance from the center axis of the capillary. The present invention is aimed at the control of the range of image to be detected as the capillary signal among the images focused on the photodetector from the capillaries. The present invention may decrease the crosstalk by controlling the detection of the light emission from the adjacent capillaries.
摘要翻译: 本发明涉及串扰的减少,其中来自特定毛细管的光发射的一部分覆盖在其相邻的毛细管的发光位置上,并被检测为来自相邻毛细管的信号。 发明人进行的研究发现串扰至少包含以下组件。 来自毛细管的信号光可以通过邻接的毛细管或多个毛细管传播,石英毛细管的外径的内表面的反射使得到达光电检测器的多个信号路径。 串扰分量可以聚焦在距离毛细管的中心轴预定距离的点处。 本发明的目的在于控制从毛细管聚焦在光电检测器上的图像中的毛细管信号的被检测图像的范围。 本发明可以通过控制来自相邻毛细管的光发射的检测来减小串扰。
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公开(公告)号:US20060091012A1
公开(公告)日:2006-05-04
申请号:US11300377
申请日:2005-12-15
申请人: Yasushi Shimizu , Toshiaki Kita , Kiyoshi Tsukada , Akihiro Suzuki , Tomonari Morioka , Masaya Kojima , Ryoji Inaba , Daizo Tokinaga , Shuhei Yamamoto , Yoshiyuki Okishima , Masao Fukunaga , Takayasu Furukawa , Tomohiro Shoji
发明人: Yasushi Shimizu , Toshiaki Kita , Kiyoshi Tsukada , Akihiro Suzuki , Tomonari Morioka , Masaya Kojima , Ryoji Inaba , Daizo Tokinaga , Shuhei Yamamoto , Yoshiyuki Okishima , Masao Fukunaga , Takayasu Furukawa , Tomohiro Shoji
IPC分类号: C02F1/40
CPC分类号: G01N27/44721 , G01N27/44782
摘要: A capillary array includes a light detection portion, a sample supply portion, a buffer solution supply portion and a voltage application portion which are necessary functions for electrophoresis, thereby, when assembling the capillary array into an electrophoresis apparatus, the same can be immediately used. Accordingly, a capillary array is provided which can be easily incorporated into an electrophoresis apparatus.
摘要翻译: 毛细管阵列包括作为电泳所需功能的光检测部分,样品供应部分,缓冲溶液供应部分和电压施加部分,从而当将毛细管阵列组装到电泳装置中时可以立即使用。 因此,提供了可以容易地并入电泳装置中的毛细管阵列。
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公开(公告)号:US07005052B2
公开(公告)日:2006-02-28
申请号:US09845303
申请日:2001-05-01
申请人: Yasushi Shimizu , Toshiaki Kita , Kiyoshi Tsukada , Akihiro Suzuki , Tomonari Morioka , Masaya Kojima , Ryoji Inaba , Daizo Tokinaga , Shuhei Yamamoto , Yoshiyuki Okishima , Masao Fukunaga , Takayasu Furukawa , Tomohiro Shoji
发明人: Yasushi Shimizu , Toshiaki Kita , Kiyoshi Tsukada , Akihiro Suzuki , Tomonari Morioka , Masaya Kojima , Ryoji Inaba , Daizo Tokinaga , Shuhei Yamamoto , Yoshiyuki Okishima , Masao Fukunaga , Takayasu Furukawa , Tomohiro Shoji
IPC分类号: G01N27/447 , C02F1/40
CPC分类号: G01N27/44721 , G01N27/44782
摘要: A capillary array includes a light detection portion, a sample supply portion, a buffer solution supply portion and a voltage application portion which are necessary functions for electrophoresis, thereby, when assembling the capillary array into an electrophoresis apparatus, the same can be immediately used. Accordingly, a capillary array is provided which can be easily incorporated into an electrophoresis apparatus.
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公开(公告)号:US08142635B2
公开(公告)日:2012-03-27
申请号:US12843103
申请日:2010-07-26
申请人: Yasushi Shimizu , Toshiaki Kita , Kiyoshi Tsukada , Akihiro Suzuki , Tomonari Morioka , Masaya Kojima , Ryoji Inaba , Daizo Tokinaga , Shuhei Yamamoto , Yoshiyuki Okishima , Masao Fukunaga , Takayasu Furukawa , Tomohiro Shoji
发明人: Yasushi Shimizu , Toshiaki Kita , Kiyoshi Tsukada , Akihiro Suzuki , Tomonari Morioka , Masaya Kojima , Ryoji Inaba , Daizo Tokinaga , Shuhei Yamamoto , Yoshiyuki Okishima , Masao Fukunaga , Takayasu Furukawa , Tomohiro Shoji
IPC分类号: C02F1/40
CPC分类号: G01N27/44721 , G01N27/44782
摘要: A capillary array includes a light detection portion, a sample supply portion, a buffer solution supply portion and a voltage application portion which are necessary functions for electrophoresis, thereby, when assembling the capillary array into an electrophoresis apparatus, the same can be immediately used. Accordingly, a capillary array is provided which can be easily incorporated into an electrophoresis apparatus.
摘要翻译: 毛细管阵列包括作为电泳所需功能的光检测部分,样品供应部分,缓冲溶液供应部分和电压施加部分,从而当将毛细管阵列组装到电泳装置中时可以立即使用。 因此,提供了可以容易地并入电泳装置中的毛细管阵列。
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公开(公告)号:US07785458B2
公开(公告)日:2010-08-31
申请号:US11300377
申请日:2005-12-15
申请人: Yasushi Shimizu , Toshiaki Kita , Kiyoshi Tsukada , Akihiro Suzuki , Tomonari Morioka , Masaya Kojima , Ryoji Inaba , Daizo Tokinaga , Shuhei Yamamoto , Yoshiyuki Okishima , Masao Fukunaga , Takayasu Furukawa , Tomohiro Shoji
发明人: Yasushi Shimizu , Toshiaki Kita , Kiyoshi Tsukada , Akihiro Suzuki , Tomonari Morioka , Masaya Kojima , Ryoji Inaba , Daizo Tokinaga , Shuhei Yamamoto , Yoshiyuki Okishima , Masao Fukunaga , Takayasu Furukawa , Tomohiro Shoji
IPC分类号: C02F1/40
CPC分类号: G01N27/44721 , G01N27/44782
摘要: A capillary array includes a light detection portion, a sample supply portion, a buffer solution supply portion and a voltage application portion which are necessary functions for electrophoresis, thereby, when assembling the capillary array into an electrophoresis apparatus, the same can be immediately used. Accordingly, a capillary array is provided which can be easily incorporated into an electrophoresis apparatus.
摘要翻译: 毛细管阵列包括作为电泳所需功能的光检测部分,样品供应部分,缓冲溶液供应部分和电压施加部分,从而当将毛细管阵列组装到电泳装置中时可以立即使用。 因此,提供了可以容易地并入电泳装置中的毛细管阵列。
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公开(公告)号:US20100288642A1
公开(公告)日:2010-11-18
申请号:US12843103
申请日:2010-07-26
申请人: Yasushi Shimizu , Toshiaki Kita , Kiyoshi Tsukada , Akihiro Suzuki , Tomonari Morioka , Masaya Kojima , Ryoji Inaba , Daizo Tokinaga , Shuhei Yamamoto , Yoshiyuki Okishima , Masao Fukunaga , Takayasu Furukawa , Tomohiro Shoji
发明人: Yasushi Shimizu , Toshiaki Kita , Kiyoshi Tsukada , Akihiro Suzuki , Tomonari Morioka , Masaya Kojima , Ryoji Inaba , Daizo Tokinaga , Shuhei Yamamoto , Yoshiyuki Okishima , Masao Fukunaga , Takayasu Furukawa , Tomohiro Shoji
IPC分类号: G01N27/26
CPC分类号: G01N27/44721 , G01N27/44782
摘要: A capillary array includes a light detection portion, a sample supply portion, a buffer solution supply portion and a voltage application portion which are necessary functions for electrophoresis, thereby, when assembling the capillary array into an electrophoresis apparatus, the same can be immediately used. Accordingly, a capillary array is provided which can be easily incorporated into an electrophoresis apparatus.
摘要翻译: 毛细管阵列包括作为电泳所需功能的光检测部分,样品供应部分,缓冲溶液供应部分和电压施加部分,从而当将毛细管阵列组装到电泳装置中时可以立即使用。 因此,提供了可以容易地并入电泳装置中的毛细管阵列。
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公开(公告)号:US20060076239A1
公开(公告)日:2006-04-13
申请号:US11245491
申请日:2005-10-07
申请人: Ryoji Inaba , Motohiro Yamazaki , Akihiro Suzuki , Miho Ozawa , Daizo Tokinaga , Tomonari Morioka , Seiichi Ugai
发明人: Ryoji Inaba , Motohiro Yamazaki , Akihiro Suzuki , Miho Ozawa , Daizo Tokinaga , Tomonari Morioka , Seiichi Ugai
IPC分类号: G01N27/447
CPC分类号: G01N27/447
摘要: In an electrophoresis apparatus comprising capillaries for containing therein fluorescence-labeled substances, and a sensor for irradiating the capillaries with exciting light and detecting fluorescences, the sensor has a substrate including a datum surface for holding thereon the capillaries, and a groove sinking from the datum surface, and the groove has a plurality of reflecting surfaces for reflecting thereon the fluorescences emitted from the capillaries by a plurality of times.
摘要翻译: 在包括用于在其中含有荧光标记物质的毛细管的电泳装置和用于用激发光照射毛细管并检测荧光的传感器中,传感器具有包括用于保持毛细管的基准表面的基底和从基准面凹下的凹槽 表面,并且凹槽具有多个反射表面,用于在其上反射从毛细管发射的荧光多次。
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公开(公告)号:US07054004B2
公开(公告)日:2006-05-30
申请号:US10704827
申请日:2003-11-12
申请人: Ryoji Inaba , Toshiaki Kita , Miho Ozawa , Tomonari Morioka , Akihiro Suzuki , Yasushi Shimizu , Masaya Kojima
发明人: Ryoji Inaba , Toshiaki Kita , Miho Ozawa , Tomonari Morioka , Akihiro Suzuki , Yasushi Shimizu , Masaya Kojima
CPC分类号: G01N27/44721 , G01N27/44782
摘要: A multi-focus capillary array that can reduce crosstalk and a capillary array photodetector are provided. On a substrate 20 on which a plurality of capillaries are aligned, a perforation 72 is formed in at least a part of an area in the rear of the capillaries when the capillary array is viewed from the photodetector.
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公开(公告)号:US20060219559A1
公开(公告)日:2006-10-05
申请号:US11395158
申请日:2006-04-03
申请人: Seiichi Ugai , Tomonari Morioka , Ryoji Inaba , Akihiro Suzuki , Yoshinori Ookoshi , Yoshiyuki Okishima , Tsukasa Ohira , Motohiro Yamazaki , Takashi Gomi
发明人: Seiichi Ugai , Tomonari Morioka , Ryoji Inaba , Akihiro Suzuki , Yoshinori Ookoshi , Yoshiyuki Okishima , Tsukasa Ohira , Motohiro Yamazaki , Takashi Gomi
IPC分类号: G01N27/00
CPC分类号: G01N27/44708
摘要: In a case where the temperature of capillaries cannot be controlled rapidly in accordance with the change of the amount of heat generated from the capillaries, the phoretic speed of the sample is not controlled constant to lower the analyzing performance for the sample. This invention intends to stabilize the electrophoretic speed. The surface of a substrate on which a plurality of capillaries are arranged is in contact with a member capable of temperature control thereby controlling the temperature of the capillaries. Since a member capable of controlling the temperature and the capillaries are in direct contact with each other according to the invention, the temperature of the capillary can be controlled rapidly at a high accuracy, so that electrophoretic speed is stabilized.
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公开(公告)号:US07473342B2
公开(公告)日:2009-01-06
申请号:US11395158
申请日:2006-04-03
申请人: Seiichi Ugai , Tomonari Morioka , Ryoji Inaba , Akihiro Suzuki , Yoshinori Ookoshi , Yoshiyuki Okishima , Tsukasa Ohira , Motohiro Yamazaki , Takashi Gomi
发明人: Seiichi Ugai , Tomonari Morioka , Ryoji Inaba , Akihiro Suzuki , Yoshinori Ookoshi , Yoshiyuki Okishima , Tsukasa Ohira , Motohiro Yamazaki , Takashi Gomi
IPC分类号: G01N27/00
CPC分类号: G01N27/44708
摘要: In a case where the temperature of capillaries cannot be controlled rapidly in accordance with the change of the amount of heat generated from the capillaries, the phoretic speed of the sample is not controlled constant to lower the analyzing performance for the sample. This invention intends to stabilize the electrophoretic speed. The surface of a substrate on which a plurality of capillaries are arranged is in contact with a member capable of temperature control thereby controlling the temperature of the capillaries. Since a member capable of controlling the temperature and the capillaries are in direct contact with each other according to the invention, the temperature of the capillary can be controlled rapidly at a high accuracy, so that electrophoretic speed is stabilized.
摘要翻译: 在毛细管的温度不能根据毛细管产生的热量的变化而不能快速控制的情况下,不将样品的凝胶速度控制在一定程度以降低样品的分析性能。 本发明旨在稳定电泳速度。 其上布置有多个毛细管的基板的表面与能够进行温度控制的构件接触,从而控制毛细管的温度。 由于根据本发明能够控制温度和毛细管的构件彼此直接接触,所以可以高精度地快速地控制毛细管的温度,使得电泳速度稳定。
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