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公开(公告)号：US09186439B2
公开(公告)日：2015-11-17
申请号：US12921443
申请日：2009-03-12
申请人： Ryuichi Morishita , Hironori Nakagami , Takashi Miyake , Makoto Mitamura , Hiroaki Nakajima , Hiroaki Matsuda , Nao Suizu , Yoshihumi Kawano , Kunihiko Takagi , Hiroyuki Tsujimoto , Yusuke Tsukada , Kaori Hara , Yohei Bando
发明人： Ryuichi Morishita , Hironori Nakagami , Takashi Miyake , Makoto Mitamura , Hiroaki Nakajima , Hiroaki Matsuda , Nao Suizu , Yoshihumi Kawano , Kunihiko Takagi , Hiroyuki Tsujimoto , Yusuke Tsukada , Kaori Hara , Yohei Bando
CPC分类号： A61L29/085 , A61L29/16 , A61L2300/258 , A61L2300/624 , A61L2400/12 , A61M25/0045 , A61M25/10 , A61M25/1027 , A61M25/104 , A61M2025/0057 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , A61M2025/1086
摘要： Biocompatible nanoparticles 1 which entrap a bioactive substance and whose surface is positive-charge-modified are electrically adhered to a balloon portion 9 of a catheter main body 5 through a negatively charged resin layer 11, and thus a nanoparticle layer 12 is formed. After the catheter main body 5 is indwell in vivo, the nanoparticles 1 are gradually eluted from the nanoparticle layer 12 and are effectively delivered to cells.
摘要翻译： 将生物活性物质捕获并将其表面进行正电荷改性的生物相容性纳米粒子1通过带负电的树脂层11电连接到导管主体5的球囊部9，形成纳米粒子层12。 在导管主体5在体内静置之后，纳米颗粒1从纳米颗粒层12逐渐洗脱并被有效地递送至细胞。
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公开(公告)号：US20110022027A1
公开(公告)日：2011-01-27
申请号：US12921443
申请日：2009-03-12
申请人： Ryuichi Morishita , Hironori Nakagami , Takashi Miyake , Makoto Mitamura , Hiroaki Nakajima , Hiroaki Matsuda , Nao Suizu , Yoshihumi Kawano , Kunihiko Takagi , Hiroyuki Tsujimoto , Yusuke Tsukada , Kaori Hara , Yohei Bando
发明人： Ryuichi Morishita , Hironori Nakagami , Takashi Miyake , Makoto Mitamura , Hiroaki Nakajima , Hiroaki Matsuda , Nao Suizu , Yoshihumi Kawano , Kunihiko Takagi , Hiroyuki Tsujimoto , Yusuke Tsukada , Kaori Hara , Yohei Bando
CPC分类号： A61L29/085 , A61L29/16 , A61L2300/258 , A61L2300/624 , A61L2400/12 , A61M25/0045 , A61M25/10 , A61M25/1027 , A61M25/104 , A61M2025/0057 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , A61M2025/1086
摘要： Biocompatible nanoparticles 1 which entrap a bioactive substance and whose surface is positive-charge-modified are electrically adhered to a balloon portion 9 of a catheter main body 5 through a negatively charged resin layer 11, and thus a nanoparticle layer 12 is formed. After the catheter main body 5 is indwell in vivo, the nanoparticles 1 are gradually eluted from the nanoparticle layer 12 and are effectively delivered to cells.
摘要翻译： 将生物活性物质捕获并将其表面进行正电荷改性的生物相容性纳米粒子1通过带负电的树脂层11电连接到导管主体5的球囊部9，形成纳米粒子层12。 在导管主体5体内静置之后，纳米颗粒1从纳米颗粒层12逐渐洗脱并被有效地递送至细胞。
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3.发明申请公开(公告)号：US20120213838A1
公开(公告)日：2012-08-23
申请号：US13392028
申请日：2010-08-26
申请人： Kensuke Egashira , Hiroyuki Tsujimoto , Kaori Hara , Yusuke Tsukada , Yohei Bando , Matsuya Manabe
发明人： Kensuke Egashira , Hiroyuki Tsujimoto , Kaori Hara , Yusuke Tsukada , Yohei Bando , Matsuya Manabe
IPC分类号： A61K9/00 , A61K31/4709 , A61K31/10 , A61P7/02 , A61F2/82 , A61K9/10 , C25D13/12 , B05D5/00 , A61K31/722 , A61P9/08 , B82Y5/00
CPC分类号： A61L31/16 , A61F2/82 , A61F2250/0067 , A61L29/043 , A61L29/06 , A61L29/08 , A61L29/085 , A61L29/16 , A61L31/022 , A61L31/042 , A61L31/06 , A61L31/08 , A61L31/10 , A61L2300/416 , A61L2300/42 , A61L2300/606 , A61L2300/624 , A61L2400/12 , A61L2400/18 , C08L5/08 , C08L67/04 , C08L5/04
摘要： The present invention provides a medical device for placement into a lumen such as a stent and a catheter whose surface is uniformly and sufficiently coated with a drug, and a process thereof with easy way and with low cost. The medical device is coated with mixed particles of drug particles whose surface is modified with positive-charge and biocompatible nanoparticles. In the invention, a drug can be taken into a cell through the dissolution of the drug particle together with the biocompatible nanoparticle after a DES is placed in a biological body.
摘要翻译： 本发明提供了一种医疗装置，其用于放置在诸如支架和内窥镜的管腔中，其表面均匀且充分地涂覆药物，并且其方法以简单的方式并且以低成本。 该医疗装置涂覆有表面用正电荷和生物相容性纳米粒子改性的药物颗粒的混合颗粒。 在本发明中，通过在将DES置于生物体中之后通过药物颗粒与生物相容纳米颗粒的溶解将药物吸入细胞。
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