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公开(公告)号：US20170321241A1
公开(公告)日：2017-11-09
申请号：US15523107
申请日：2015-10-29
申请人： SANOFI
发明人： Claus Lattemann , Thomas Stillger , Bernd Janocha , Hans-Falk Rasser , Sebastian Rissom , Simone Anderko , Rita Bernhardt , Frank Hannemann
IPC分类号： C12P33/06
CPC分类号： C12P33/06
摘要： Generally, the present invention relates to the field of steroid hydroxylation. More specifically, the present invention relates to a method for the 21-hydroxylation of steroids in cells. It also relates to cells expressing a steroid 21-hydroxylating enzyme or steroid 21-hydroxylase, expression vectors comprising a nucleic acid encoding for a steroid 21-hydroxylase and a kit for carrying out the method for the 21-hydroxylation of steroids in cells.
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公开(公告)号：US10385376B2
公开(公告)日：2019-08-20
申请号：US15523107
申请日：2015-10-29
申请人： SANOFI
发明人： Claus Lattemann , Thomas Stillger , Bernd Janocha , Hans-Falk Rasser , Sebastian Rissom , Simone Anderko , Rita Bernhardt , Frank Hannemann
IPC分类号： C12P33/06
摘要： Generally, the present invention relates to the field of steroid hydroxylation. More specifically, the present invention relates to a method for the 21-hydroxylation of steroids in cells. It also relates to cells expressing a steroid 21-hydroxylating enzyme or steroid 21-hydroxylase, expression vectors comprising a nucleic acid encoding for a steroid 21-hydroxylase and a kit for carrying out the method for the 21-hydroxylation of steroids in cells.
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公开(公告)号：US10308972B2
公开(公告)日：2019-06-04
申请号：US14898655
申请日：2014-06-17
申请人： Sanofi
摘要： The subject of the present invention is a whole-cell catalysis process for converting substrates of cytochrome P450 monooxygenases of eukaryotic origin into valuable biotechnological products. The subject of the present invention is also microorganisms genetically engineered to achieve those biotransformations with high rates and processes to prepare these microorganism strains.
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4.发明申请公开(公告)号：US20160376625A1
公开(公告)日：2016-12-29
申请号：US14898655
申请日：2014-06-17
申请人： SANOFI
CPC分类号： C12P33/16 , C12N9/0081 , C12N9/0095 , C12N9/1029 , C12P7/625 , C12P33/00 , C12Y114/15006 , C12Y203/01
摘要： The subject of the present invention is a whole-cell catalysis process for converting substrates of cytochrome P450 monooxygenases of eukaryotic origin into valuable biotechnological products. The subject of the present invention is also microorganisms genetically engineered to achieve those biotransformations with high rates and processes to prepare these microorganism strains.
摘要翻译： 本发明的主题是将真核来源的细胞色素P450单加氧酶底物转化为有价值的生物技术产品的全细胞催化方法。 本发明的主题也是基因工程改造以实现具有高速率的这些生物转化和制备这些微生物菌株的方法的微生物。
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公开(公告)号：US11608514B2
公开(公告)日：2023-03-21
申请号：US16453651
申请日：2019-06-26
申请人： SANOFI
发明人： Claus Lattemann , Thomas Stillger , Bernd Janocha , Hans-Falk Rasser , Sebastian Rissom , Simone Anderko , Rita Bernhardt , Frank Hannemann
IPC分类号： C12P33/06
摘要： Generally, the present invention relates to the field of steroid hydroxylation. More specifically, the present invention relates to a method for the 21-hydroxylation of steroids in cells. It also relates to cells expressing a steroid 21-hydroxylating enzyme or steroid 21-hydroxylase, expression vectors comprising a nucleic acid encoding for a steroid 21-hydroxylase and a kit for carrying out the method for the 21-hydroxylation of steroids in cells.
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公开(公告)号：US20190352690A1
公开(公告)日：2019-11-21
申请号：US16453651
申请日：2019-06-26
申请人： SANOFI
发明人： Claus Lattemann , Thomas Stillger , Bernd Janocha , Hans-Falk Rasser , Sebastian Rissom , Simone Anderko , Rita Bernhardt , Frank Hannemann
IPC分类号： C12P33/06
摘要： Generally, the present invention relates to the field of steroid hydroxylation. More specifically, the present invention relates to a method for the 21-hydroxylation of steroids in cells. It also relates to cells expressing a steroid 21-hydroxylating enzyme or steroid 21-hydroxylase, expression vectors comprising a nucleic acid encoding for a steroid 21-hydroxylase and a kit for carrying out the method for the 21-hydroxylation of steroids in cells.
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