公开(公告)号：US10308972B2

公开(公告)日：2019-06-04

申请号：US14898655

申请日：2014-06-17

申请人： Sanofi

发明人： Adrian Gerber ,  Frank Hannemann ,  Sabrina Bleif ,  Michael Kleser ,  Rita Bernhardt

IPC分类号： C12P33/16 ,  C12P33/00 ,  C12N1/21 ,  C12N9/02 ,  C12P7/62 ,  C12N9/10

摘要： The subject of the present invention is a whole-cell catalysis process for converting substrates of cytochrome P450 monooxygenases of eukaryotic origin into valuable biotechnological products. The subject of the present invention is also microorganisms genetically engineered to achieve those biotransformations with high rates and processes to prepare these microorganism strains.

公开(公告)号：US20160376625A1

公开(公告)日：2016-12-29

申请号：US14898655

申请日：2014-06-17

申请人： SANOFI

发明人： Adrian Gerber ,  Frank Hannemann ,  Sabrina Bleif ,  Michael Kleser ,  Rita Bernhardt

IPC分类号： C12P33/16 ,  C12N9/10 ,  C12N9/02

CPC分类号： C12P33/16 ,  C12N9/0081 ,  C12N9/0095 ,  C12N9/1029 ,  C12P7/625 ,  C12P33/00 ,  C12Y114/15006 ,  C12Y203/01

摘要： The subject of the present invention is a whole-cell catalysis process for converting substrates of cytochrome P450 monooxygenases of eukaryotic origin into valuable biotechnological products. The subject of the present invention is also microorganisms genetically engineered to achieve those biotransformations with high rates and processes to prepare these microorganism strains.

摘要翻译： 本发明的主题是将真核来源的细胞色素P450单加氧酶底物转化为有价值的生物技术产品的全细胞催化方法。 本发明的主题也是基因工程改造以实现具有高速率的这些生物转化和制备这些微生物菌株的方法的微生物。