公开(公告)号：US20200207804A1

公开(公告)日：2020-07-02

申请号：US16500812

申请日：2018-04-03

Applicant: SCARAB GENOMICS, LLC

Inventor： Frederick R. BLATTNER ,  David FRISCH ,  Charles LANDRY ,  John BRANDON

IPC: C07K1/16 ,  C07K14/34 ,  C07K1/18 ,  B01D15/38 ,  B01D15/36 ,  B01D15/32 ,  B01D15/18

Abstract: The present invention relates to the use of redox agents for purification of the CRM 197 variant of diphtheria toxin. The invention further relates to multi-step purification of CRM 197 from bacterial fermentates.

公开(公告)号：US20200318150A1

公开(公告)日：2020-10-08

申请号：US16644444

申请日：2018-09-04

Applicant: SCARAB GENOMICS LLC

Inventor： Frederick R. BLATTNER ,  Robert E. NOVY ,  David A. FRISCH ,  Charles LANDRY ,  Hyunsic CHOI ,  Eric A. STEFFEN ,  John BRANDON

IPC: C12P21/06 ,  C12N9/18 ,  C12N1/20 ,  C07K14/34 ,  C07K14/285 ,  C07K14/21

Abstract: Provided herein are methods for the improved production of periplasmic-targeted recombinant proteins in E. coli host strains. Also provided are E. coli host strains with improved capacity for producing recombinant proteins.

公开(公告)号：US20230287472A1

公开(公告)日：2023-09-14

申请号：US18299479

申请日：2023-04-12

Applicant: SCARAB GENOMICS LLC

Inventor： Frederick R. BLATTNER ,  Robert E. NOVY ,  David A. FRISCH ,  Charles LANDRY ,  Hyunsic CHOI ,  Eric A. STEFFEN ,  John BRANDON

IPC: C12P21/06 ,  C07K14/21 ,  C07K14/285 ,  C07K14/34 ,  C12N1/20 ,  C12N9/18

CPC classification number: C12P21/06 ,  C07K14/21 ,  C07K14/285 ,  C07K14/34 ,  C12N1/20 ,  C12N9/18 ,  C07K2319/02

Abstract: Provided herein are E. coli host strains with improved capacity for producing recombinant proteins.