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公开(公告)号：US20200207804A1
公开(公告)日：2020-07-02
申请号：US16500812
申请日：2018-04-03
Applicant: SCARAB GENOMICS, LLC
Inventor： Frederick R. BLATTNER , David FRISCH , Charles LANDRY , John BRANDON
Abstract: The present invention relates to the use of redox agents for purification of the CRM 197 variant of diphtheria toxin. The invention further relates to multi-step purification of CRM 197 from bacterial fermentates.
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公开(公告)号：US20200318150A1
公开(公告)日：2020-10-08
申请号：US16644444
申请日：2018-09-04
Applicant: SCARAB GENOMICS LLC
Inventor： Frederick R. BLATTNER , Robert E. NOVY , David A. FRISCH , Charles LANDRY , Hyunsic CHOI , Eric A. STEFFEN , John BRANDON
Abstract: Provided herein are methods for the improved production of periplasmic-targeted recombinant proteins in E. coli host strains. Also provided are E. coli host strains with improved capacity for producing recombinant proteins.
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公开(公告)号：US20170114318A1
公开(公告)日：2017-04-27
申请号：US15394468
申请日：2016-12-29
Applicant: SCARAB GENOMICS, LLC
Inventor： Frederick R. BLATTNER , Balint CSORGO , Gyorgy POSFAI
CPC classification number: C12N1/08 , C12N9/1007 , C12N9/1252 , C12N15/70 , C12P21/00 , C12P21/02 , C12R1/19 , C12Y201/01037
Abstract: Reduced genome bacteria with improved genetic stability are provided. Also provided are methods of producing polypeptides using the reduced genome bacteria with improved genetic stability.
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公开(公告)号：US20180208933A1
公开(公告)日：2018-07-26
申请号：US15904297
申请日：2018-02-23
Applicant: SCARAB GENOMICS, LLC
Inventor： Frederick R. BLATTNER , David A. FRISCH , Robert E. NOVY , Terrance M. HENKER , Eric A. STEFFEN , Jose A. SANCHEZ , Christopher R. BLATTNER , Hyunsic CHOI , Gyorgy POSFAI
CPC classification number: C12N15/70 , C12N9/1022 , C12N9/1048 , C12R1/19 , C12Y202/01006 , C12Y204/00
Abstract: E. coli bacteria comprising genetic modifications to enhance fermentability and production of protein and nucleic acids are provided.
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公开(公告)号：US20170073379A1
公开(公告)日：2017-03-16
申请号：US15122891
申请日：2015-03-02
Applicant: SCARAB GENOMICS, LLC
Inventor： Cristopher R. BLATTNER , David FRISCH , Robert E. NOVY , Terrance M. HENKER , Eric A. STEFFEN , Frederick R. BLATTNER , Hyunsic CHOI , Gyorgy Posfai , Charles F. LANDRY
Abstract: Rediced genome or native K12 strain E. coli bacteria comprising expression vectors encoding a recombinant CRM197 protein and their use in the production of CRM 197 is provided. The CRM 197 protein may be fused to a signal sequence that directs the expressed CRM197 protein to the periplasm of the E. coli host.
Abstract translation: 提供了包含编码重组CRM197蛋白的表达载体及其在生产CRM 197中的应用的经重修的基因组或天然K12菌株的大肠杆菌细菌。 CRM 197蛋白可以融合到将表达的CRM197蛋白质引导到大肠杆菌宿主的周质的信号序列上。
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Patent Agency Ranking
公开(公告)号：US20230287472A1
公开(公告)日：2023-09-14
申请号：US18299479
申请日：2023-04-12
Applicant: SCARAB GENOMICS LLC
Inventor： Frederick R. BLATTNER , Robert E. NOVY , David A. FRISCH , Charles LANDRY , Hyunsic CHOI , Eric A. STEFFEN , John BRANDON
CPC classification number: C12P21/06 , C07K14/21 , C07K14/285 , C07K14/34 , C12N1/20 , C12N9/18 , C07K2319/02
Abstract: Provided herein are E. coli host strains with improved capacity for producing recombinant proteins.
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7.发明申请公开(公告)号：US20200216798A1
公开(公告)日：2020-07-09
申请号：US16824583
申请日：2020-03-19
Applicant: Scarab Genomics, LLC
Inventor： Frederick R. BLATTNER
Abstract: Methods and compositions for long term continuous flow fermentation using a two vessel continuous culture fermentation apparatus are described.
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8.发明申请公开(公告)号：US20180087018A1
公开(公告)日：2018-03-29
申请号：US15563540
申请日：2016-04-01
Applicant: Scarab Genomics, LLC
Inventor： Frederick R. BLATTNER
CPC classification number: C12M23/58 , C07K14/21 , C07K14/34 , C07K14/47 , C12M27/00 , C12M29/00 , C12M29/06 , C12N1/20 , C12P21/00
Abstract: A two-vessel continuous flow system in conjunction with low mutation reduced genome bacterial strains provides a platform for long term extended fermentations. Such systems require modification of standard fermentation devices such as probes, pumps and monitoring systems as well as improved procedures for feed delivery, culture monitoring and product harvesting methods. An optimized two-vessel system for producing large quantities of fermentation products from small volume, long duration continuous fermentations represents a significant improvement over existing fermentation strategies. Methods and compositions for long term continuous flow fermentation using a two vessel continuous culture fermentation apparatus are described.
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公开(公告)号：US20160298126A1
公开(公告)日：2016-10-13
申请号：US15036376
申请日：2014-11-13
Applicant: SCARAB GENOMICS, LLC
Inventor： Frederick R. BLATTNER , David A. FRISCH , Robert E. NOVY , Terrance M. HENKER , Eric A. STEFFEN , Jose A. SANCHEZ , Christopher R. BLATTNER , Hyunsic CHOI , Gyorgy POSFAI
CPC classification number: C12N15/70 , C12N9/1022 , C12N9/1048 , C12R1/19 , C12Y202/01006 , C12Y204/00
Abstract: E. coli bacteria comprising genetic modifications to enhance fermentability and production of protein and nucleic acids are provided.
Abstract translation: 提供包含遗传修饰以增强发酵能力和产生蛋白质和核酸的大肠杆菌。
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公开(公告)号：US20160251609A1
公开(公告)日：2016-09-01
申请号：US15154827
申请日：2016-05-13
Applicant: SCARAB GENOMICS, LLC
Inventor： Frederick R. BLATTNER , Balint CSORGO , Gyorgy POSFAL
CPC classification number: C12N1/08 , C12N9/1007 , C12N9/1252 , C12N15/70 , C12P21/00 , C12P21/02 , C12R1/19 , C12Y201/01037
Abstract: Reduced genome bacteria with improved genetic stability are provided. Also provided are methods of producing polypeptides using the reduced genome bacteria with improved genetic stability.
Abstract translation: 提供了具有改善的遗传稳定性的减少的基因组细菌。 还提供了使用具有改善的遗传稳定性的还原的基因组细菌产生多肽的方法。
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