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公开(公告)号：US20170333558A1
公开(公告)日：2017-11-23
申请号：US15524651
申请日：2015-11-06
申请人： Scholar Rock, Inc.
发明人： Michelle Straub , Dong Yun Lee , William K. McConaughy , Jared J. Sheehan , Katherine Jane Turner , Nagesh K. Mahanthappa , Gregory J. Carven , Justin W. Jackson
IPC分类号： A61K39/395 , C07K14/475 , G01N33/74 , C07K16/22
CPC分类号： A61K39/39533 , A61K2039/505 , C07K14/475 , C07K16/22 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/622 , C07K2317/76 , C07K2317/92 , G01N33/74 , G01N2800/10
摘要： Aspects of the present disclosure relate to antibodies that specifically bind proMyostatin and/or latent Myostatin and uses thereof.
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公开(公告)号：US20190085067A1
公开(公告)日：2019-03-21
申请号：US16209078
申请日：2018-12-04
申请人： Scholar Rock, Inc.
IPC分类号： C07K16/22 , C07K14/495 , C07K16/28 , A61K39/395 , C07K16/00 , C12N15/10 , A61K38/00
摘要： Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-β superfamily of proteins.
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公开(公告)号：US20170073406A1
公开(公告)日：2017-03-16
申请号：US15309141
申请日：2015-05-06
申请人： SCHOLAR ROCK, INC.
CPC分类号： C07K16/22 , A61K38/18 , A61K38/1841 , C07K14/495 , C07K14/70546 , C07K2317/73 , C07K2317/75 , C07K2317/92
摘要： Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-β superfamily of proteins.
摘要翻译： 本文提供了可用于调节生长因子水平和/或活性的蛋白质，抗体，测定和方法。 在一些实施方案中，这些生长因子是蛋白质的TGF-β超家族的成员。
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公开(公告)号：US20160289318A1
公开(公告)日：2016-10-06
申请号：US15187278
申请日：2016-06-20
申请人： SCHOLAR ROCK, INC.
IPC分类号： C07K16/22 , C07K14/495 , C12N15/10 , C07K16/00
CPC分类号： C07K16/22 , A61K38/00 , A61K39/3955 , C07K14/495 , C07K16/005 , C07K16/28 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/32 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N15/1037 , G01N2333/71
摘要： Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-β superfamily of proteins.
摘要翻译： 本文提供了可用于调节生长因子水平和/或活性的蛋白质，抗体，测定和方法。 在一些实施方案中，这些生长因子是蛋白质的TGF-β超家族的成员。
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公开(公告)号：US11925683B2
公开(公告)日：2024-03-12
申请号：US17446897
申请日：2021-09-03
申请人： SCHOLAR ROCK, INC.
发明人： Michelle Straub , Dong Yun Lee , William K. McConaughy , Katherine Jane Turner , Nagesh K. Mahanthappa , Justin W. Jackson
IPC分类号： C07K16/22 , A61K39/395 , G01N33/53 , G01N33/74 , A61K39/00 , C07K14/475
CPC分类号： A61K39/39533 , A61K39/3955 , C07K16/22 , G01N33/53 , G01N33/74 , A61K2039/505 , C07K14/475 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N2800/10
摘要： Aspects of the present disclosure relate to antibodies that specifically bind proMyostatin and/or latent Myostatin and uses thereof.
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公开(公告)号：US10307480B2
公开(公告)日：2019-06-04
申请号：US15524651
申请日：2015-11-06
申请人： Scholar Rock, Inc.
发明人： Michelle Straub , Dong Yun Lee , William K. McConaughy , Katherine Jane Turner , Nagesh K. Mahanthappa , Justin W. Jackson
IPC分类号： C07K16/22 , A61K39/395 , G01N33/53 , C07K14/475 , G01N33/74 , A61K39/00
摘要： Aspects of the present disclosure relate to antibodies that specifically bind proMyostatin and/or latent Myostatin and uses thereof.
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公开(公告)号：US20180016332A1
公开(公告)日：2018-01-18
申请号：US15659974
申请日：2017-07-26
申请人： Scholar Rock, Inc.
IPC分类号： C07K16/22 , A61K39/395 , C07K16/00 , C07K16/28 , C12N15/10 , C07K14/495 , A61K38/00
CPC分类号： C07K16/22 , A61K38/00 , A61K39/3955 , C07K14/495 , C07K16/005 , C07K16/28 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/32 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N15/1037 , G01N2333/71
摘要： Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-β superfamily of proteins.
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公开(公告)号：US09758576B2
公开(公告)日：2017-09-12
申请号：US14795012
申请日：2015-07-09
申请人： SCHOLAR ROCK, INC.
IPC分类号： C07K16/22 , A61K39/395 , C07K14/495 , C07K16/00 , C07K16/28 , C12N15/10 , A61K38/00
CPC分类号： C07K16/22 , A61K38/00 , A61K39/3955 , C07K14/495 , C07K16/005 , C07K16/28 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/32 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N15/1037 , G01N2333/71
摘要： Provided herein are antibodies that bind growth factor prodomain complexes, for example, growth factor prodomain complexes that include GDF-8 growth factor and GDF-8 prodomain. Also included are antibodies that bind growth factor prodomain complexes that have been altered by proteolytic processing.
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公开(公告)号：US20160031980A1
公开(公告)日：2016-02-04
申请号：US14795012
申请日：2015-07-09
申请人： SCHOLAR ROCK, INC.
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K38/00 , A61K39/3955 , C07K14/495 , C07K16/005 , C07K16/28 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/32 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N15/1037 , G01N2333/71
摘要： Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-β superfamily of proteins.
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公开(公告)号：US20150337034A1
公开(公告)日：2015-11-26
申请号：US14795033
申请日：2015-07-09
申请人： Scholar Rock, Inc.
CPC分类号： C07K16/22 , A61K38/00 , A61K39/3955 , C07K14/495 , C07K16/005 , C07K16/28 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/32 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N15/1037 , G01N2333/71
摘要： Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-β superfamily of proteins.
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