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公开(公告)号：US11325980B2
公开(公告)日：2022-05-10
申请号：US16085511
申请日：2017-03-15
发明人： Django Sussman , Fu Li , Ana Kostic
IPC分类号： A61K31/337 , A61K31/555 , A61K31/704 , C07K16/30 , A61K39/395 , A61K47/68 , C07K16/28 , A61K9/00 , A61K39/00
摘要： The invention provides methods of treating a subject having or at risk of cancer by administering a LIV-1 antibody drug conjugate and a chemotherapeutic.
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公开(公告)号：US10912842B2
公开(公告)日：2021-02-09
申请号：US15735738
申请日：2016-06-09
IPC分类号： A61K47/68 , C07K16/28 , A61K31/5513 , A61K31/5517 , A61P35/02 , A61P35/00 , C07K16/30 , A61K39/00
摘要： The invention provides murine, chimeric, and humanized antibodies that specifically bind to CD123 and conjugates thereof.
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公开(公告)号：US10787514B2
公开(公告)日：2020-09-29
申请号：US15411947
申请日：2017-01-20
IPC分类号： C07K16/28 , A61K39/00 , A61K31/551 , A61K47/68
摘要： The invention provides murine, chimeric, and humanized antibodies that specifically hind to CD33. The antibodies are useful for treatment and diagnoses of various cancers as well as detecting CD33.
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公开(公告)号：US20190085091A1
公开(公告)日：2019-03-21
申请号：US16085511
申请日：2017-03-15
发明人： Django Sussman , Fu Li , Ana Kostic
IPC分类号： C07K16/30 , A61K9/00 , A61K31/337 , A61K31/555 , A61K31/704
摘要： The invention provides methods of treating a subject having or at risk of cancer by administering a LIV-1 antibody drug conjugate and a chemotherapeutic.
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公开(公告)号：US20180169261A1
公开(公告)日：2018-06-21
申请号：US15735738
申请日：2016-06-09
CPC分类号： A61K47/6849 , A61K31/5513 , A61K31/5517 , A61K47/6803 , A61K47/6851 , A61K2039/505 , A61P35/00 , A61P35/02 , C07K16/2866 , C07K16/30 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/73 , C07K2317/92
摘要： The invention provides murine, chimeric, and humanized antibodies that specifically bind to CD123 and conjugates thereof.
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6.发明申请公开(公告)号：US20150337259A1
公开(公告)日：2015-11-26
申请号：US14632925
申请日：2015-02-26
发明人： Stephen C. Alley , Scott C. Jeffrey , Django Sussman , Dennis R. Benjamin , Brian Toki , Patrick J. Burke
IPC分类号： C12N5/00
CPC分类号： C12N5/0037 , C07H13/04 , C07K16/00 , C07K2317/72 , C07K2317/732
摘要： The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
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公开(公告)号：US20130259860A1
公开(公告)日：2013-10-03
申请号：US13990778
申请日：2011-12-06
CPC分类号： C07K16/28 , A61K47/6865 , A61K2039/505 , C07K16/3015 , C07K16/3053 , C07K16/3069 , C07K16/465 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/92
摘要： The invention provides humanized antibodies that specifically bind to LIV-1. The antibodies are useful for treatment and diagnoses of various cancers as well as detecting LIV-1.
摘要翻译： 本发明提供特异性结合LIV-1的人源化抗体。 该抗体可用于治疗和诊断各种癌症以及检测LIV-1。
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公开(公告)号：US20190023801A1
公开(公告)日：2019-01-24
申请号：US16151012
申请日：2018-10-03
摘要： The invention provides humanized antibodies that specifically bind to BCMA. The antibodies are useful for treatment and diagnoses of various cancers and immune disorders as well as detecting BCMA.
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公开(公告)号：US20180079810A1
公开(公告)日：2018-03-22
申请号：US15692424
申请日：2017-08-31
CPC分类号： C07K16/28 , A61K47/6865 , A61K2039/505 , C07K16/3015 , C07K16/3053 , C07K16/3069 , C07K16/465 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/92
摘要： The invention provides humanized antibodies that specifically bind to LIV-1. The antibodies are useful for treatment and diagnoses of various cancers as well as detecting LIV-1.
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10.发明授权公开(公告)号：US09816069B2
公开(公告)日：2017-11-14
申请号：US14632925
申请日：2015-02-26
发明人： Stephen C. Alley , Scott C. Jeffrey , Django Sussman , Dennis R. Benjamin , Brian Toki , Patrick J. Burke
CPC分类号： C12N5/0037 , C07H13/04 , C07K16/00 , C07K2317/72 , C07K2317/732
摘要： The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
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