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公开(公告)号：US20230158505A1
公开(公告)日：2023-05-25
申请号：US17912216
申请日：2021-03-23
CPC分类号： B01L3/5082 , A61B5/15 , G01N1/38 , A61B10/0096
摘要： A specimen collection container is provided, the specimen collection container being capable of suppressing a change in a mixing ratio of a specimen collected to a liquid contained even when a long period of time has elapsed after manufacturing. A specimen collection container according to the present invention is a specimen collection container into which a specimen is collected, the specimen collection container including: a container main body having an opening; a plug attached to the opening; a barrier film disposed on an outer surface of the container main body; and a liquid contained in the container main body, the barrier film having a water vapor transmission rate at 40° C. and 90% RH of 0.8 g/(m2·day) or less.
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2.发明申请公开(公告)号：US20220226752A1
公开(公告)日：2022-07-21
申请号：US17608281
申请日：2020-05-19
发明人： Kuniya KOMAI , Hironobu ISOGAWA , Hideo ANRAKU
摘要： Provided is a composition for mononuclear cell-containing plasma separation capable of suppressing a flow of the composition for mononuclear cell-containing plasma separation during storage, capable of satisfactorily forming a partition during centrifugation, and capable of yielding mononuclear cell-containing plasma with little admixture of blood cell components other than mononuclear cells. The composition for mononuclear cell-containing plasma separation according to the present invention contains an organic component having fluidity at 25° C. and two or more kinds of inorganic fine powders, and has a specific gravity of 1.060 or more and 1.080 or less at 25° C.
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3.发明公开公开(公告)号：US20240172974A1
公开(公告)日：2024-05-30
申请号：US18283330
申请日：2022-03-23
发明人： Kuniya KOMAI , Tomonori INOUE
CPC分类号： A61B5/150755 , B01D21/262 , G01N1/4077
摘要： Provided is a blood separation composition with which a partition wall can be satisfactorily formed even when the blood separation composition is stored for a long time. A blood separation composition according to the present invention contains an organic component having fluidity at 25° C. and fine powder silica, the fine powder silica including hydrophobic silica having a hydrophobicity of 60% or more as measured by a methanol wettability method.
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公开(公告)号：US20230090675A1
公开(公告)日：2023-03-23
申请号：US17908407
申请日：2021-03-11
发明人： Kuniya KOMAI , Hironobu ISOGAWA
IPC分类号： B01L3/00 , G01N33/487
摘要： Provided is a blood collection container with which a specimen with a high leukocyte recovery rate and a small amount of contaminating erythrocytes can be obtained. A blood collection container according to the present invention is a blood collection container by which a predetermined amount of blood is collected, the blood collection container including: a blood collection container main body; and a hemocyte separation material contained in the blood collection container main body, the hemocyte separation material having a specific gravity at 25° C. of 1.075 or more and 1.093 or less, and the blood collection container including: a configuration of including a hemagglutinating agent contained in the blood collection container main body (configuration A2); or a configuration of including an osmotic pressure regulator contained in the blood collection container main body, and when a water-soluble component contained in the blood collection container main body is dissolved with physiological saline in an amount equal to a predetermined amount of blood to be collected in the blood collection container to obtain a solution for osmotic pressure measurement, the solution for osmotic pressure measurement having an osmotic pressure of 300 mOsm/L or more and 500 mOsm/L or less (configuration B2).
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5.发明公开公开(公告)号：US20240334924A1
公开(公告)日：2024-10-10
申请号：US18579616
申请日：2022-07-20
发明人： Takaya UCHIYAMA , Kuniya KOMAI , Tomonori INOUE
IPC分类号： A01N1/02 , C12Q1/6806
CPC分类号： A01N1/021 , A01N1/0242 , A01N1/0284 , C12Q1/6806
摘要： Provided is a storage solution for a cell-containing solution capable of suppressing leakage of genomic DNA to the outside of cells when a mixed solution of a cell-containing solution and a storage solution is stored under refrigeration. A storage solution for a cell-containing solution according to the present invention contains a formaldehyde donor compound (A) and a compound (B) that is an inorganic salt, an organic acid, or an organic salt, an electrical conductivity of the storage solution being 3 ms/cm or more and 20 ms/cm or less.
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公开(公告)号：US20240245844A1
公开(公告)日：2024-07-25
申请号：US18564326
申请日：2022-05-27
发明人： Kuniya KOMAI , Takaya UCHIYAMA , Marika KANDA , Tomonori INOUE
CPC分类号： A61M1/3693 , A61J1/05
摘要： Provided is a blood collection container capable of suppressing contamination of plasma by white blood cells and components in white blood cells. A blood collection container according to the present invention includes a blood collection container main body, a plasma separation material stored in the blood collection container main body, and an aqueous solution stored in the blood collection container main body, in which a solute contained in the aqueous solution contains an anticoagulant, and a total concentration of the solute in the aqueous solution is 100 mM or more and 450 mM or less, or 1200 mM or more.
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公开(公告)号：US20220386913A1
公开(公告)日：2022-12-08
申请号：US17775461
申请日：2020-12-02
发明人： Kuniya KOMAI
IPC分类号： A61B5/15
摘要： There is provided a blood collection container capable of suppressing the contamination of white blood cells into blood plasma. A blood collection container according to the present invention is a blood collection container into which a predetermined amount of blood is collected. The blood collection container includes a blood collection container main body, and a blood plasma separation material, an osmotic pressure regulator, and an anticoagulant contained in the blood collection container main body. The specific gravity of the blood plasma separation material at 25° C. is 1.030 or more and 1.120 or less. When the osmotic pressure regulator and the anticoagulant contained in the blood collection container main body are dissolved in an amount of physiological saline solution equivalent to a predetermined amount of blood collected in the blood collection container to obtain an osmotic pressure measurement solution, the specific gravity of the blood plasma separation material at 25° C. and the osmotic pressure of the osmotic pressure measurement solution satisfy a specific relationship.
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公开(公告)号：US20220133961A1
公开(公告)日：2022-05-05
申请号：US17426014
申请日：2020-01-29
发明人： Kuniya KOMAI
摘要： Provided is a clot adhesion preventing agent capable of suppressing adhesion of clot to the inner wall surface of a blood collection container. The clot adhesion preventing agent according to the present invention includes a polyether compound or a silicone oil, and an amino acid.
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