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公开(公告)号:US10053666B2
公开(公告)日:2018-08-21
申请号:US15026117
申请日:2014-09-29
发明人: Xiaohua Lu , Jiayin Yang , Bo Yang
IPC分类号: C12N5/079 , A61K35/30 , C12N5/0793 , A61K45/06 , A61K31/436 , A61K31/203 , A61K31/366 , A61K31/4409 , A61K31/506 , A61K31/5377
CPC分类号: C12N5/0619 , A61K31/203 , A61K31/366 , A61K31/436 , A61K31/4409 , A61K31/506 , A61K31/5377 , A61K35/30 , A61K45/06 , C12N2500/32 , C12N2500/38 , C12N2501/01 , C12N2501/105 , C12N2501/115 , C12N2501/13 , C12N2501/135 , C12N2501/375 , C12N2501/385 , C12N2501/41 , C12N2501/727 , C12N2501/998 , C12N2506/1307 , A61K2300/00
摘要: Usage of a protein kinase inhibitor in preparing a neural cell from a differentiated non-neural cell is provided.
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2.
公开(公告)号:US11834648B2
公开(公告)日:2023-12-05
申请号:US16761935
申请日:2017-11-06
发明人: Yubo Yan , Jian Fu , Min Zhou , Yuqing Liu , Lixiang Jiang , Bo Yang , Jiayin Yang
IPC分类号: C12N5/074 , C12N5/0793 , C12N15/90 , G01N33/50 , G01N33/68
CPC分类号: C12N5/0696 , C12N5/0619 , C12N15/90 , G01N33/5058 , G01N33/6896 , C12N2503/02 , C12N2506/025 , C12N2506/45 , C12N2510/00 , C12N2740/10043 , G01N2333/4709
摘要: A method of generating a cellular model of Alzheimer's disease (AD) comprises integrating AD related gene to hiPSC to induce increased beta secretase and/or Abeta 42 peptides, and the cellular model of Alzheimer's disease (AD) is prepared by the method.
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