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1.发明公开公开(公告)号：US20240226329A1
公开(公告)日：2024-07-11
申请号：US18022051
申请日：2020-08-20
发明人： Chenli Liu , Yuxuan Dong , Xuan Guo , Qian Chen , Yong Hu , Liangxia Ai , Hao Zhang
CPC分类号： A61K48/0058 , A61K35/74 , A61K38/204 , A61K38/2066 , A61K45/06
摘要： A bacterial targeting vector and use thereof in tumor treatment, in particular, a bacterial targeting vector carrying a cytokine such as interleukin 6 and interleukin 10 or carrying a polynucleotide such as mRNA of the cytokine and use thereof in tumor treatment. An attenuated chassis bacterium capable of targeting solid tumors can be used as a delivery carrier of a tumor therapy molecule, and achieve expression and controllable release of a human/murine cytokine, thereby achieving anti-tumor effects.
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公开(公告)号：US20200332282A1
公开(公告)日：2020-10-22
申请号：US16904549
申请日：2020-06-17
发明人： Chenli Liu , Wangsheng Lai , Qian Chen , Ting Wei , Chenjian Sun
摘要： A visual continuous spatial directed evolution method is disclosed. The host grows and moves in a solid culture space, the host carrying a foreign target gene to be evolved and containing a gene element that assists the evolution of the target gene, the target gene being correlated with the growth and movement of the host. Depending on different spatial distribution patterns formed in the solid culture space during the growth and movement of the host, screening is performed to obtain an evolved product. This method is carried out directly in the solid culture space. Depending on images of different spatial distribution morphologies visible to the naked eye that are locally formed, selection of evolved products is performed without the need for liquid fed-batch culture equipment. In addition, the evolution effect is visually observed through the infection spots formed during evolution, so that no real-time monitoring equipment is required.
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公开(公告)号：US20240318353A1
公开(公告)日：2024-09-26
申请号：US18353653
申请日：2023-07-17
发明人： Chenli Liu , Wangsheng Lai , Qian Chen , Ting Wei , Chenjian Sun
摘要： A visual continuous spatial directed evolution method is disclosed. The host grows and moves in a solid culture space, the host carrying a foreign target gene to be evolved and containing a gene element that assists the evolution of the target gene, the target gene being correlated with the growth and movement of the host. Depending on different spatial distribution patterns formed in the solid culture space during the growth and movement of the host, screening is performed to obtain an evolved product. This method is carried out directly in the solid culture space. Depending on images of different spatial distribution morphologies visible to the naked eye that are locally formed, selection of evolved products is performed without the need for liquid fed-batch culture equipment. In addition, the evolution effect is visually observed through the infection spots formed during evolution, so that no real-time monitoring equipment is required.
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公开(公告)号：US11702764B2
公开(公告)日：2023-07-18
申请号：US16904549
申请日：2020-06-17
发明人： Chenli Liu , Wangsheng Lai , Qian Chen , Ting Wei , Chenjian Sun
摘要： A visual continuous spatial directed evolution method is disclosed. The host grows and moves in a solid culture space, the host carrying a foreign target gene to be evolved and containing a gene element that assists the evolution of the target gene, the target gene being correlated with the growth and movement of the host. Depending on different spatial distribution patterns formed in the solid culture space during the growth and movement of the host, screening is performed to obtain an evolved product. This method is carried out directly in the solid culture space. Depending on images of different spatial distribution morphologies visible to the naked eye that are locally formed, selection of evolved products is performed without the need for liquid fed-batch culture equipment. In addition, the evolution effect is visually observed through the infection spots formed during evolution, so that no real-time monitoring equipment is required.
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