公开(公告)号：US20230258614A1

公开(公告)日：2023-08-17

申请号：US18095858

申请日：2023-01-11

Applicant: SHIMADZU CORPORATION

Inventor： Kota KAMEI ,  Daisuke KITABAYASHI

IPC: G01N30/38 ,  G01N30/32

CPC classification number: G01N30/38 ,  G01N30/32 ,  G01N2030/027

Abstract: A liquid chromatograph (1) includes a liquid-sending unit (20) for sending a mobile phase from a reservoir (11) to a column (14) through a tube (12) at a predetermined pressure. The unit (20) includes a pump (21) having a suction port (211) connected to the reservoir and an ejection port (212) connected to the tube directly or via another pump. A check valve (232) is provided for the ejection port. For the precompression process for opening this valve, a pressure application controller (27) controls the pressure applied to the mobile phase within the pump, based on the compressibility of the mobile phase and the amount of compression of the inner wall of the pump resulting from the pressure application, so as to reach the pressure at which the check valve opens before the mobile phase suctioned from the suction port is to be ejected from the ejection port.

公开(公告)号：US20220146474A1

公开(公告)日：2022-05-12

申请号：US17438419

申请日：2019-03-13

Applicant: SHIMADZU CORPORATION

Inventor： Tomohiro GOMI ,  Daisuke KITABAYASHI

IPC: G01N30/86 ,  G01N30/32

Abstract: A liquid chromatograph (1) includes a liquid sending pump (14) for sending a mobile phase, a sample injector (4) that injects a sample into an analysis flow path (12) through which a mobile phase from the liquid sending pump (14) flows, a separation column (6) that is provided on the analysis flow path (12) and is to separate a sample that has been injected into the analysis flow path (12) by the sample injector (4) into components, a pressure sensor (16) for detecting a liquid sending pressure in the analysis flow path (12) located at a position farther upstream than the separation column (6), a damper capacity holder (22) that holds an internal capacity of a system through which a mobile phase from the liquid sending pump (14) flows as a damper capacity, a reference value determiner (24) configured to determine a reference value of a fluctuation range of the liquid sending pressure when a liquid sending failure of the liquid sending pump (14) occurs, using at least the damper capacity held by the damper capacity holder (22), and a liquid sending failure detector (26) that is configured to periodically acquire a liquid sending pressure detected by the pressure sensor (16), obtain a fluctuation range of the liquid sending pressure in a certain driving period of the liquid sending pump (14) and detect a liquid sending failure using the obtained fluctuation range and the reference value determined by the reference value determiner (24).

公开(公告)号：US20210072199A1

公开(公告)日：2021-03-11

申请号：US17048671

申请日：2019-01-16

Applicant: SHIMADZU CORPORATION

Inventor： Yusuke YOKOI ,  Daisuke KITABAYASHI

IPC: G01N30/30 ,  G01N30/32 ,  G01N30/16

Abstract: A chromatography system includes a liquid sending pump for sending a mobile phase in an analysis flow path, a sample injector that injects a sample into the analysis flow path, a separation column for separating the sample into components, a column oven for storing the separation column and adjusting a temperature of the separation column to a preset target temperature, a liquid sending controller configured to control an operation of the liquid sending pump, and a column protection flow rate setter configured to set a column protection flow rate. The liquid sending controller is configured to control the operation of the liquid sending pump such that, when the liquid sending pump starts sending the mobile phase, the flow rate of the mobile phase flowing through the analysis flow path does not exceed the column protection flow rate until a temperature in the column oven reaches the target temperature.

公开(公告)号：US20220128533A1

公开(公告)日：2022-04-28

申请号：US17438421

申请日：2019-10-16

Applicant: SHIMADZU CORPORATION

Inventor： Tomohiro GOMI ,  Daisuke KITABAYASHI ,  Shinya IMAMURA ,  Keisuke OGAWA ,  Masataka NIKKO ,  Masahide GUNJI

IPC: G01N30/86 ,  G01N30/32

Abstract: A liquid sending failure detector acquires periodically a liquid sending pressure of a liquid sending mechanism consecutively sends liquid using at least one plunger pump that sends liquid by reciprocally driving a plunger such that a fluctuation is read in one driving period of the liquid sending mechanism, and detect a liquid sending failure of the liquid sending mechanism using an acquired liquid sending pressure. The liquid sending failure detector executes a pulsation detection step of obtaining a fluctuation range of the liquid sending pressure in a certain driving period of the liquid sending mechanism and detecting pulsation on a condition that a count of consecutive periods in which the fluctuation range exceeds a predetermined reference value exceeds a predetermined reference count, and a liquid sending failure detection step of detecting a liquid sending failure of the liquid sending mechanism when the pulsation is detected in the pulsation detection step.

公开(公告)号：US20220146473A1

公开(公告)日：2022-05-12

申请号：US17438418

申请日：2019-03-13

Applicant: SHIMADZU CORPORATION

Inventor： Tomohiro GOMI ,  Daisuke KITABAYASHI ,  Shinya IMAMURA ,  Keisuke OGAWA

IPC: G01N30/86 ,  G01N30/32

Abstract: A liquid chromatographic system (1) includes an analysis flow path (12) to which at least one liquid sending pump (14) is connected and through which liquid that is sent by the liquid sending pump (14) flows, a sample injector (4) that injects a sample into the analysis flow path (12), a separation column (6) that is provided on the analysis flow path (12) and is to separate a sample that has been injected into the analysis flow path (12) into components, a detector (8) that is provided on the analysis flow path (12) and is to detect sample components obtained by separation in the separation column (6), a system configuration specifier (26) that specifies a count and a connection structure of the liquid sending pumps (14) connected to the analysis flow path (12) as a system configuration, a condition holder (18) holding a condition that is for detection of a liquid sending failure of the liquid sending pump (14) and is preset in regard to each type of the system configuration, a condition determiner (20) that is configured to determine the condition corresponding to a system configuration specified by the system configuration specifier (26) from among conditions held by the condition holder (18), and a liquid sending failure detector (22) configured to detect a liquid sending failure of the liquid sending pump (14) using the condition determined by the condition determiner (20).