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1.发明授权公开(公告)号：US09947520B2
公开(公告)日：2018-04-17
申请号：US15122214
申请日：2015-02-17
申请人： SHIMADZU CORPORATION
CPC分类号： H01J49/0045 , G01N27/622 , H01J49/0072 , H01J49/06 , H01J49/164
摘要： A cloud of ions captured in an ion trap (2) is irradiated with a stream of hydrogen radicals cast through a radical particle introduction hole (26) bored in a ring electrode (21) at a flow rate of 4×1010 [atoms/s]. As a result, a radical induced dissociation which does not rely on the transfer or capture of electrons occurs within the ion trap (2), whereby c/z-type fragment ions are efficiently generated. After the irradiation with the hydrogen radicals, a supplemental collision-induced dissociation process may performed by introducing inert gas into the ion trap (2) and resonantly exciting the ions, in order to further promote the generation of the c/z-type fragment ions. In this manner, according to the present invention, it is possible to achieve radical induced dissociation of singly-charged ions derived from a peptide and use the thereby generated c/z-type fragment ions for mass spectrometry.
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2.发明授权公开(公告)号：US11309174B2
公开(公告)日：2022-04-19
申请号：US16348935
申请日：2016-11-18
申请人： SHIMADZU CORPORATION
发明人： Kenichi Taniguchi , Takeshi Uchida , Hiroto Itoi
摘要： Provided is an ionization method for ionizing a sample 21 adhered to a tip of a probe 11 that is electrically conductive, by applying an ionization voltage to the probe 11 to electrically charge the sample 21. The ionization method includes: subjecting the probe 11 to treatment to make a surface of the probe 11 homogenous; causing adhesion of the sample 21 to the tip of the probe 11; and ionizing the sample 21 by applying the ionization voltage to the probe 11 to electrically charge the sample 21. The treatment for making the surface of the probe 11 homogenous can be implemented by, for example, causing corona discharge at the probe 11.
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