公开(公告)号：US10919035B2

公开(公告)日：2021-02-16

申请号：US15554443

申请日：2016-02-24

Applicant: Sony Corporation

Inventor： Shin Masuhara ,  Yoshiaki Kato ,  Ryousuke Minami ,  Toshio Watanabe

IPC: G01N21/05 ,  B01L3/00 ,  G01N21/03

Abstract: According to some aspects, a microfluidic device is provided, comprising a sample holding chamber; and at least one flow path connected to the sample holding chamber configured to supply liquid into the sample holding chamber, wherein the sample holding chamber includes a first inner surface; and a light irradiation region intersecting the first inner surface and configured to receive light from outside of the sample holding chamber to irradiate liquid inside the sample holding chamber, wherein the first inner surface includes at least one recess shaped so as to contain gas bubbles present within the liquid, and wherein the at least one recess is located outside of the light irradiation region.

公开(公告)号：US11135587B2

公开(公告)日：2021-10-05

申请号：US16481717

申请日：2017-11-21

Applicant: SONY CORPORATION

Inventor： Kensuke Kojima ,  Shin Masuhara

IPC: B01L3/00 ,  C12M3/06 ,  G01N15/14

Abstract: There is provided a particle supplementing chip provided with a structure for trapping a particle, and for preventing the trapped particle from being greatly deformed by a suction force. With respect to this point, the present technology provides a particle trapping chip including a first channel, a second channel, a first recess that is open on the first channel side, a second recess that is provided side by side with the first recess, a connecting portion connecting the first recess and the second recess, and a communicating portion allowing the second recess and the second channel to communicate with each other.

公开(公告)号：US20190168222A1

公开(公告)日：2019-06-06

申请号：US16325453

申请日：2017-07-21

Applicant: Sony Corporation

Inventor： Kensuke Kojima ,  Shin Masuhara ,  Toshio Watanabe

IPC: B01L3/00 ,  B81B1/00 ,  G01N15/10

Abstract: Provided is a single-particle capturing apparatus in which one particle can be captured in one recess portion (16) while preventing another particle from being accumulated on a captured particle.A single-particle capturing apparatus including: a flow channel (12) on a substrate (11), a wave structure with a mountain portion (13) and a valley portion (14) on the flow channel (12), and a recess portion (16) at a top portion (15) of the mountain portion (13), the recess portion (16) including a draw-in passage (17).

公开(公告)号：US20140290786A1

公开(公告)日：2014-10-02

申请号：US14222149

申请日：2014-03-21

Applicant: Sony Corporation

Inventor： Tatsumi Ito ,  Shin Masuhara

IPC: F16L9/00

CPC classification number: B01F13/0059 ,  B01F5/0647 ,  B01F5/0655

Abstract: A microfluidic channel includes an agitating flow channel whose central axis is a three-dimensional curve.

Abstract translation: 微流体通道包括其中心轴是三维曲线的搅动流动通道。

公开(公告)号：US20210364410A1

公开(公告)日：2021-11-25

申请号：US16970307

申请日：2019-11-11

Applicant: Sony Corporation

Inventor： Hiroyuki Hosokawa ,  Tasuku Yotoriyama ,  Shin Masuhara ,  Isamu Nakao

IPC: G01N15/14 ,  G06K9/32 ,  G06K9/46 ,  G06K9/62 ,  C12Q1/6813

Abstract: To provide a technology for confirming that a desired particle is recovered in single cell analysis.
The present technology provides a particle confirming method including a correlating step of correlating ID information possessed by a particle trapped in a well in a particle trapping region with position information of the well, a discharging step of discharging the particle from the well, an ID information acquiring step of acquiring ID information of the particle after the discharging step, and a confirming step of confirming the position of the well in which the particle has been trapped, on the basis of the acquired ID information. In addition, the present technology also provides a particle trapping chip and a particle analyzing system to be used for carrying out the method.

公开(公告)号：US20200330989A1

公开(公告)日：2020-10-22

申请号：US16643234

申请日：2018-09-06

Applicant: Sony Corporation

Inventor： Shin Masuhara ,  Kensuke Kojima ,  Hiroyuki Hosokawa ,  Yoshiaki Kato ,  Marcaurele Brun ,  Toshio Watanabe

IPC: B01L3/00 ,  G01N15/14

Abstract: There is provided a microfluidic device for capturing particles comprising a particle capturing chamber (100) including at least: a particle capturing unit (101) including one of at least one well (106) or at least one through hole (108); and a particle capturing channel unit (102) used for capturing a particle in the well or with the through hole, in which the particle is captured in the well or with the through hole by being sucked, via the particle capturing channel unit, in a direction opposite to a direction (114) on which the particle settles. Such a configuration has for result that the particles that are not captured in the well or with the through hole are prevented from staying in the vicinity of the well or the through hole of the particle capturing unit when suction is stopped.

公开(公告)号：US20180065119A1

公开(公告)日：2018-03-08

申请号：US15554443

申请日：2016-02-24

Applicant: Sony Corporation

Inventor： Shin Masuhara ,  Yoshiaki Kato ,  Ryousuke Minami ,  Toshio Watanabe

IPC: B01L3/00 ,  G01N21/05

CPC classification number: B01L3/502707 ,  B01L3/502715 ,  B01L3/502723 ,  B01L2200/0684 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0864 ,  G01N21/05 ,  G01N2021/0378 ,  G01N2021/054

Abstract: According to some aspects, a microfluidic device is provided, comprising a sample holding chamber; and at least one flow path connected to the sample holding chamber configured to supply liquid into the sample holding chamber, wherein the sample holding chamber includes a first inner surface; and a light irradiation region intersecting the first inner surface and configured to receive light from outside of the sample holding chamber to irradiate liquid inside the sample holding chamber, wherein the first inner surface includes at least one recess shaped so as to contain gas bubbles present within the liquid, and wherein the at least one recess is located outside of the light irradiation region.