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公开(公告)号：US11738214B2
公开(公告)日：2023-08-29
申请号：US16853637
申请日：2020-04-20
CPC分类号： A61N7/00 , A61M37/0092 , A61B2090/378 , A61N7/02 , A61N2007/0021 , A61N2007/0026 , A61N2007/0043 , A61N2007/0047 , A61N2007/0073 , A61N2007/0078
摘要： An apparatus having an implantable ultrasound generating treating device to induce brain disorder treatment, suitable for implantation in or under the skull bone of a patient, includes several ultrasound generating transducers, which are connectable by a common electrical connection circuit to a generator, and wherein the ultrasound generating transducers each have one or several operating frequencies. The transducers include the group of transducers having several transducers driven by a same electrical drive signal, and connected to the generator system by a common electrical connection circuit, where the electric drive signal serves both as power signal and as a control signal for operating selectively, within said group, at least one or the other of a first transducer or sub-group of transducers, and of a second transducer or sub-group of transducers. The apparatus is also used to treat brain disorders.
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公开(公告)号：US12029652B2
公开(公告)日：2024-07-09
申请号：US16623974
申请日：2018-06-19
CPC分类号： A61F2/2875 , A61B8/0808 , A61B8/4281 , A61B8/481 , A61B90/39 , A61N7/00 , A61B2090/3925 , A61B2090/3962 , A61F2002/3009 , A61N2007/0021 , A61N2007/0052
摘要： An assembly for imaging and/or treating brain tissue, having at least one acoustic window which comprises a plate that is transparent to ultrasonic waves, and at least one positioning marker which facilitates positioning of a probe for generating ultrasonic waves so as to be aligned with said acoustic window.
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公开(公告)号：US11872413B2
公开(公告)日：2024-01-16
申请号：US16623964
申请日：2018-06-19
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61N2007/0021 , A61N2007/0078
摘要： The present invention relates to a method for controlling a probe for the treatment of brain tissue using an assembly comprising the probe and an acoustic window (1), the probe (2) including a plurality of transducers (21) for generating ultrasound waves, the method comprising: —a phase of detection: •of the probe transducers situated above the cranium (4) of the patient, and •of the probe transducers situated above the acoustic window (1), so as to permit: •deactivation of the transducers situated above the cranium (4) of the patient, •activation of the transducers situated above the acoustic window (1).
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公开(公告)号：US20170259086A1
公开(公告)日：2017-09-14
申请号：US15067334
申请日：2016-03-11
IPC分类号： A61N7/00 , A61K31/282 , A61K41/00
CPC分类号： A61N7/00 , A61K31/495 , A61K31/555 , A61K41/0028 , A61N2007/0021
摘要： The present invention relates to a method for transiently disrupting a region of the blood-brain barrier (BBB) of a human using ultrasounds in the presence of an ultrasound contrast agent, and uses thereof. The method comprises the application of at least one ultrasound (US) beam with a pressure level higher than 1 MPa and a resonance frequency ranging from 0.5 to 1.5 MHz.
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公开(公告)号：US10981021B2
公开(公告)日：2021-04-20
申请号：US15067334
申请日：2016-03-11
IPC分类号： A61N7/00 , A61K41/00 , A61K31/555 , A61K31/495
摘要： The present invention relates to a method for transiently disrupting a region of the blood-brain barrier (BBB) of a human using ultrasounds in the presence of an ultrasound contrast agent, and uses thereof. The method comprises the application of at least one ultrasound (US) beam with a pressure level higher than 1 MPa and a resonance frequency ranging from 0.5 to 1.5 MHz.
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公开(公告)号：US10987524B2
公开(公告)日：2021-04-27
申请号：US15789426
申请日：2017-10-20
申请人： Vermon S.A. , Institut National de la Sante et de la Recherche Medicale (INSERM), U1032 , Universite Pierre Et Marie Curie (Paris 6) , CarThera S.A.S.
发明人： Alexandre Carpentier , An Nguyen-Dinh , Jean-Yves Chapelon , Rémi Dufait , Christophe Notard , Françoise Chavrier , Cyril Lafon , Michael Canney , William Apoutou N'Djin
摘要： An interstitial ultrasound thermal ablation applicator for conformal treatment of an inhomogeneous tumor lesion includes: a body having a longitudinal axis; and a plurality of array transducers mounted on the body, arranged side by side and having azimuth directions parallel to the longitudinal axis of the body, and having outer faces disposed in a polygonal arrangement; the plurality of array transducers having predetermined elevation dimensions defined for directing emitted ultrasonic energy to obtain a conformal volume treatment of the tumor lesions. An electronic driving method for driving an applicator having multiple independent transducer elements arranged in rows and columns includes: controlling focal parameters of each row and column of transducer elements; and controlling a contribution of each row and column of transducer elements in a manner to provide a conformal ablated volume.
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公开(公告)号：US11517364B2
公开(公告)日：2022-12-06
申请号：US16316161
申请日：2017-07-06
申请人： CARTHERA
发明人： Michael Canney
摘要： The present invention relates to a pathology treatment apparatus comprising: an ultrasound generator device (1), a remote control unit (2) for delivering electricity to the device (1) during at least an activation cycle and determining and controlling the operating parameters thereof, each activation cycle (50) being preceded by a standby cycle, means (31, 32) of electrical connection between the device (1) and the control unit (2), notable in that the control unit (2) is programmed to detect a fault with the electrical connection between the device (1) and the said control unit (2) during at least a standby cycle.
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公开(公告)号：US11135455B2
公开(公告)日：2021-10-05
申请号：US16093718
申请日：2017-04-14
申请人： CARTHERA
摘要： The present invention relates to an ultrasonic probe for heating, internally, an ultrasonically absorbent target medium, the probe comprising: at least one piezoelectric transducer (21) having a front face (212) intended to be positioned facing the target medium and a back face (211) opposite the front face (212), the transducer being able to emit at least one primary wave emanating from its front face and at least one secondary wave emanating from its back face, the probe being noteworthy in that it furthermore comprises: a reflector (24) facing the back face (211) of the transducer (21), the reflector (24) being suitable for reflecting the secondary wave emitted by the transducer (21); and a cooling-fluid layer (25) between the transducer (21) and the reflector (24).
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