公开(公告)号：US10533991B2

公开(公告)日：2020-01-14

申请号：US15125896

申请日：2015-03-13

Applicant: STC.UNM

Inventor： David G. Whitten ,  Harry Pappas ,  Eric H. Hill ,  Yue Zhang ,  Eva Yung Hua Chi ,  Arjun Thapa ,  Ying Wang ,  Patrick L. Donabedian ,  Kiran Bhaskar

IPC: G01N33/52 ,  C08G61/02 ,  C12N1/20 ,  C12Q1/44 ,  C12Q1/46

Abstract: Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethynylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.

公开(公告)号：US12163953B2

公开(公告)日：2024-12-10

申请号：US16707501

申请日：2019-12-09

Applicant: STC.UNM

Inventor： David G. Whitten ,  Harry Craig Pappas ,  Eric H. Hill ,  Yue Zhang ,  Eva Yung Hua Chi ,  Arjun Thapa ,  Ying Wang ,  Patrick L Donabedian ,  Kiran Bhaskar

IPC: C12N1/20 ,  C07K14/65 ,  C08G61/02 ,  C12Q1/44 ,  C12Q1/46 ,  G01N33/52

Abstract: Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethylylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.

公开(公告)号：US20200158720A1

公开(公告)日：2020-05-21

申请号：US16707501

申请日：2019-12-09

Applicant: STC.UNM

Inventor： David G. Whitten ,  Harry Craig Pappas ,  Eric H. Hill ,  Yue Zhang ,  Eva Yung Hua Chi ,  Arjun Thapa ,  Ying Wang ,  Patrick L. Donabedian ,  Kiran Bhaskar

IPC: G01N33/52 ,  C12Q1/46 ,  C12Q1/44 ,  C12N1/20 ,  C08G61/02

Abstract: Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethylylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.