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公开(公告)号：US20200158720A1
公开(公告)日：2020-05-21
申请号：US16707501
申请日：2019-12-09
Applicant: STC.UNM
Inventor： David G. Whitten , Harry Craig Pappas , Eric H. Hill , Yue Zhang , Eva Yung Hua Chi , Arjun Thapa , Ying Wang , Patrick L. Donabedian , Kiran Bhaskar
Abstract: Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethylylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.
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公开(公告)号：US10533991B2
公开(公告)日：2020-01-14
申请号：US15125896
申请日：2015-03-13
Applicant: STC.UNM
Inventor： David G. Whitten , Harry Pappas , Eric H. Hill , Yue Zhang , Eva Yung Hua Chi , Arjun Thapa , Ying Wang , Patrick L. Donabedian , Kiran Bhaskar
Abstract: Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethynylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.
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公开(公告)号：US20190116797A1
公开(公告)日：2019-04-25
申请号：US16192248
申请日：2018-11-15
Applicant: University of Florida Research Foundation, Inc. , STC.UNM
Inventor： David G. Whitten , Kirk S. Schanze , Anand Parthasarathy , Eunkyung Ji , Motokatsu Ogawa , Thomas S. Corbitt , Dimitri Dascier , Ying Wang , Linnea K. Ista , Eric H. Hill
IPC: A01N43/90 , C08G61/02 , C07D409/14 , C08G75/00 , A01N25/08 , A01N33/10 , C07C217/14 , A01N25/10 , A01N33/12 , A01N41/04 , A01N43/10 , C08G61/12 , C07D487/08 , C07D333/16 , C07C309/24 , C07C217/20 , C07C309/11
Abstract: The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.
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Patent Agency Ranking
公开(公告)号：US09968698B2
公开(公告)日：2018-05-15
申请号：US14533612
申请日：2014-11-05
Applicant: STC.UNM
Inventor： David G. Whitten , Eric H. Hill , Harry C. Pappas
Abstract: The invention relates to compositions including a charged oligo-phenylene ethynylene singlet-oxygen sensitizer and an oppositely-charged surfactant, which show an enhanced biocidal activity relative to a comparable concentration of the oligo-phenylene ethynylene without the oppositely-charged surfactant. The enhancement of biocidal activity is observed with an anionic oligo-phenylene ethynylene in the presence of a cationic surfactant such as TTAB, and with a cationic oligo-phenylene ethynylene in the presence of an anionic surfactant such as SDS.
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公开(公告)号：US12163953B2
公开(公告)日：2024-12-10
申请号：US16707501
申请日：2019-12-09
Applicant: STC.UNM
Inventor： David G. Whitten , Harry Craig Pappas , Eric H. Hill , Yue Zhang , Eva Yung Hua Chi , Arjun Thapa , Ying Wang , Patrick L Donabedian , Kiran Bhaskar
Abstract: Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethylylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.
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公开(公告)号：US10750746B2
公开(公告)日：2020-08-25
申请号：US16192248
申请日：2018-11-15
Applicant: University of Florida Research Foundation, Inc. , STC.UNM
Inventor： David G. Whitten , Kirk S. Schanze , Anand Parthasarathy , Eunkyung Ji , Motokatsu Ogawa , Thomas S. Corbitt , Dimitri Dascier , Ying Wang , Linnea K. Ista , Eric H. Hill
IPC: A01N43/90 , C07C217/14 , C07C309/11 , A01N25/10 , C07D409/14 , C07C217/20 , C07C309/24 , C07D333/16 , C07D487/08 , C08G61/02 , C08G75/00 , C08G61/12 , A01N25/08 , A01N33/10 , A01N33/12 , A01N41/04 , A01N43/10
Abstract: The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.
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公开(公告)号：US10174042B2
公开(公告)日：2019-01-08
申请号：US15348756
申请日：2016-11-10
Applicant: University of Florida Research Foundation, Inc. , STC.UNM
Inventor： David G. Whitten , Kirk S. Schanze , Anand Parthasarathy , Eunkyung Ji , Motokatsu Ogawa , Thomas S. Corbitt , Dimitri Dascier , Ying Wang , Linnea K. Ista , Eric H. Hill
IPC: C07D487/08 , C07C217/14 , C07C309/11 , C07C217/20 , C07C309/24 , C07D333/16 , C08G61/02 , C08G75/00 , C08G61/12
Abstract: The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.
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公开(公告)号：US20180020663A1
公开(公告)日：2018-01-25
申请号：US15668390
申请日：2017-08-03
Applicant: University of Florida Research Foundation, Inc. , STC.UNM
Inventor： David G. Whitten , Harry Craig Pappas , Eric H. Hill , Kirk S. Schanze , Anand Parthasarathy , Yun Huang , Thomas S. Corbitt
CPC classification number: A01N43/50 , A01N33/08 , A01N33/12 , A01N43/90 , A61L15/24 , A61L15/46 , A61L2300/404 , A61L2420/02 , C07D233/64 , C07D409/06
Abstract: Various embodiments disclosed relate to conjugated polyelectrolytes and methods of using the same. Various embodiments provide a conjugated polyelectrolyte including a subunit having the structure —R1—Y—R2—Z—. At each occurrence, R1 is independently chosen from 1,4-bonded phenylene substituted by —X—R3—R4 j times and 2,5-bonded thiophene substituted by —X—R3—R4 j times. At each occurrence, Y is independently chosen from a bond and —C≡C—. At each occurrence, R2 is independently chosen from a bond, a substituted or unsubstituted phenylene, thiophenylene, azulenylene, heptalenylene, biphenylene, indacenylene, fluorenylene, phenanthrenylene, triphenylenylene, pyrenylene, naphthacenylene, chrysenylene, biphenylenylene, anthracenylene, and naphthylene. At each occurrence, Z is independently chosen from a bond and —C≡C—. The variables j, R3, and R4 are as defined herein.
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