公开(公告)号：US12163953B2

公开(公告)日：2024-12-10

申请号：US16707501

申请日：2019-12-09

Applicant: STC.UNM

Inventor： David G. Whitten ,  Harry Craig Pappas ,  Eric H. Hill ,  Yue Zhang ,  Eva Yung Hua Chi ,  Arjun Thapa ,  Ying Wang ,  Patrick L Donabedian ,  Kiran Bhaskar

IPC: C12N1/20 ,  C07K14/65 ,  C08G61/02 ,  C12Q1/44 ,  C12Q1/46 ,  G01N33/52

Abstract: Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethylylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.

公开(公告)号：US20200158720A1

公开(公告)日：2020-05-21

申请号：US16707501

申请日：2019-12-09

Applicant: STC.UNM

Inventor： David G. Whitten ,  Harry Craig Pappas ,  Eric H. Hill ,  Yue Zhang ,  Eva Yung Hua Chi ,  Arjun Thapa ,  Ying Wang ,  Patrick L. Donabedian ,  Kiran Bhaskar

IPC: G01N33/52 ,  C12Q1/46 ,  C12Q1/44 ,  C12N1/20 ,  C08G61/02

Abstract: Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethylylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.

公开(公告)号：US20180020663A1

公开(公告)日：2018-01-25

申请号：US15668390

申请日：2017-08-03

Applicant: University of Florida Research Foundation, Inc. ,  STC.UNM

Inventor： David G. Whitten ,  Harry Craig Pappas ,  Eric H. Hill ,  Kirk S. Schanze ,  Anand Parthasarathy ,  Yun Huang ,  Thomas S. Corbitt

IPC: A01N43/50 ,  A01N33/12 ,  A61L15/46 ,  A01N43/90 ,  A61L15/24 ,  A01N33/08

CPC classification number: A01N43/50 ,  A01N33/08 ,  A01N33/12 ,  A01N43/90 ,  A61L15/24 ,  A61L15/46 ,  A61L2300/404 ,  A61L2420/02 ,  C07D233/64 ,  C07D409/06

Abstract: Various embodiments disclosed relate to conjugated polyelectrolytes and methods of using the same. Various embodiments provide a conjugated polyelectrolyte including a subunit having the structure —R1—Y—R2—Z—. At each occurrence, R1 is independently chosen from 1,4-bonded phenylene substituted by —X—R3—R4 j times and 2,5-bonded thiophene substituted by —X—R3—R4 j times. At each occurrence, Y is independently chosen from a bond and —C≡C—. At each occurrence, R2 is independently chosen from a bond, a substituted or unsubstituted phenylene, thiophenylene, azulenylene, heptalenylene, biphenylene, indacenylene, fluorenylene, phenanthrenylene, triphenylenylene, pyrenylene, naphthacenylene, chrysenylene, biphenylenylene, anthracenylene, and naphthylene. At each occurrence, Z is independently chosen from a bond and —C≡C—. The variables j, R3, and R4 are as defined herein.