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    VIRAL CONSTRUCTS FOR USE IN ENHANCING T-CELL PRIMING DURING VACCINATION
    6.
    发明公开
    VIRAL CONSTRUCTS FOR USE IN ENHANCING T-CELL PRIMING DURING VACCINATION 审中-公开

    公开(公告)号：US20240344082A1

    公开(公告)日：2024-10-17

    申请号：US18229070

    申请日：2023-08-01

    Applicant: GeoVax, Inc. ,  Leidos, Inc.

    Inventor： Mary Jo Hauser ,  Arban Domi ,  Gabriel Gutierrez ,  James Pannucci ,  Kotraiah Vinayaka ,  Timothy Phares ,  Peter Buontempo ,  Cecille Browne

    IPC: C12N15/86 ,  A61K39/00 ,  C07K14/47

    CPC classification number: C12N15/86 ,  C07K14/4703 ,  A61K39/00 ,  C07K2319/036 ,  C12N2710/24143

    Abstract: The invention provides virus-based expression vectors comprising immune-checkpoint inhibitor inserts for use as effective adjuvants in enhancing T-cell priming to an antigen in a host during a vaccination regimen. In particular, the compositions described herein are novel recombinant modified vaccinia Ankara (MVA) viral constructs encoding one or more peptides which, upon administration, are expressed in a multimer conformation and subsequently cleaved and secreted from the cell. Such peptides are capable of downregulating an immune checkpoint pathway, for example, by inhibiting the activation of programmed-cell death protein 1 (PD-1), programed cell death ligand 1 (PD-L1), cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), or another immune checkpoint regulator, or a combination thereof. When used in concert with the administration of an antigen during a vaccination strategy, the immune checkpoint expressing MVA viral construct provides significantly improved antigen-specific CD8+ T cell expansion, increased antigenic responses, and improved vaccination efficacy.

    LAG3 Binding Peptides
    8.
    发明申请
    LAG3 Binding Peptides 审中-公开

    公开(公告)号：US20200369766A1

    公开(公告)日：2020-11-26

    申请号：US16879884

    申请日：2020-05-21

    Applicant: Leidos, Inc.

    Inventor： Gabriel M. Gutierrez ,  Vinayaka Kotraiah ,  Timothy W. Phares ,  James Pannucci ,  Marc Mansour

    IPC: C07K16/28 ,  C12N15/11 ,  A61K39/395 ,  A61K45/06

    Abstract: This disclosure provides peptides which bind to LAG3 and can be used to block the interaction of LAG 3 with other molecules such as MHC-II, FGL1, and α-synuclein. These peptides can be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, or inhibiting the progression of a synucleinopathy, inhibiting the progression of sepsis, inhibiting the progression of an infectious disease, and enhancing a response to a vaccine.

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