公开(公告)号：US20030148385A1

公开(公告)日：2003-08-07

申请号：US10264606

申请日：2002-10-04

Applicant: STERIS INC.

Inventor： Kathleen M. Antloga ,  Gerald E. McDonnell

IPC: G01N033/53

CPC classification number: A61L2/186 ,  A61K31/327 ,  A61L2/0082 ,  A61L2/0088 ,  A61L2/14 ,  A61L2/208 ,  A61L2/28 ,  A61L2202/17 ,  A61L2202/24 ,  C11D3/3947 ,  C11D11/0023

Abstract: A proteinaceous material has been found to show similar activity and treatment response to that of disease causing prions, such as CJD. A prion model which incorporates the proteinaceous material has a variety of applications. The model has an ability to be cultured either in vivo or in vitro, allowing rapid screening of potential drugs for treating animals or humans, or methods of treating food products or items which may come into contact with prions, such as medical or dental devices. Several treatment methods and materials have been developed using the model.

Abstract translation: 已经发现蛋白质材料显示与引起朊病毒的疾病相似的活性和治疗反应，例如CJD。 结合蛋白质材料的朊病毒模型具有多种应用。 该模型具有在体内或体外培养的能力，允许对用于治疗动物或人的潜在药物的快速筛选，或处理可能与朊病毒例如医疗或牙科装置接触的食品或物品的方法。 已经使用该模型开发了几种处理方法和材料。

公开(公告)号：US20020159915A1

公开(公告)日：2002-10-31

申请号：US10077224

申请日：2002-02-15

Applicant: STERIS INC.

Inventor： Francis J. Zelina ,  Gerald E. McDonnell ,  Aaron L. Hill ,  Thaddeus Mielnik ,  Iain F. McVey ,  Peter J. Buczynski

IPC: A61L002/24 ,  A61L002/20

CPC classification number: A61L2/208 ,  A61L2/186 ,  A61L2202/23 ,  B65B55/025 ,  B65B55/10 ,  B67C7/0073

Abstract: A flash vapor generator (10) provides a constant flow of vaporized hydrogen peroxide for rapidly sterilizing a large decontamination tunnel (11) with a high container throughput. The vaporizer includes a heated block which defines an interior bore or bores. The conditions within the decontamination tunnel are carefully monitored to avoid condensation of the vapor while maintaining the vapor as close as possible to the saturation limit.

Abstract translation: 闪蒸发生器（10）提供恒定的气化过氧化氢流，用于快速灭菌具有高容器生产能力的大型去污通道（11）。 蒸发器包括限定内孔或孔的加热块。 仔细监测净化隧道内的条件，以避免蒸汽冷凝，同时保持蒸气尽可能接近饱和极限。

公开(公告)号：US20040238014A1

公开(公告)日：2004-12-02

申请号：US10446763

申请日：2003-05-28

Applicant: STERIS Inc.

Inventor： Eric Halstead ,  Gerald E. McDonnell ,  Robert M. Priest

IPC: B08B001/02

CPC classification number: A61L2/24 ,  A61B1/00068 ,  A61B1/00137 ,  A61B1/123 ,  A61B1/125 ,  A61B90/70 ,  A61B2090/701 ,  A61L2/18 ,  B08B9/00 ,  B08B11/02

Abstract: A fixture for holding a valve assembly in an automated washing system, wherein the valve assembly is movable between an opened position and a normally closed position. The fixture is comprised of first and second housing sections that are releaseably attachable to each other. The housing sections define an internal cavity that is dimensioned to hold the valve assembly in an opened position. A fluid inlet is in communication with the chamber, and is attachable to a source of an anti-microbial fluid in the washing system. A fluid outlet communicates with the chamber to allow the anti-microbial fluid to exit the fixture.

Abstract translation: 一种用于将阀组件保持在自动洗涤系统中的夹具，其中所述阀组件可在打开位置和常闭位置之间移动。 固定装置包括可松开地相互连接的第一和第二壳体部分。 壳体部分限定内部空腔，其尺寸被设计成将阀组件保持在打开位置。 流体入口与腔室连通，并且可连接到洗涤系统中的抗微生物流体源。 流体出口与腔室连通以允许抗微生物流体离开固定装置。

公开(公告)号：US20030073592A1

公开(公告)日：2003-04-17

申请号：US10098767

申请日：2002-03-14

Applicant: STERIS INC.

Inventor： Gerald E. McDonnell ,  Herbert J. Kaiser ,  Kathleen M. Antloga ,  Jennifer A. Scocos

IPC: C02F005/08 ,  C11D001/00

CPC classification number: A61L2/186 ,  A61K31/327 ,  A61L2/0082 ,  A61L2/0088 ,  A61L2/14 ,  A61L2/208 ,  A61L2/22 ,  A61L2202/24 ,  C11D3/3947 ,  C11D11/0023

Abstract: A surface which carries a material which is infected with prions is cleaned with an alkaline cleaning solution to remove as much proteinaceous material as possible from the surface. The cleaning agent is an alkaline cleaning agent which attacks prions remaining on the surface and which attacks prions removed from the surface during the cleaning step. After the cleaning solution is drained, a solution of surfactants, buffers, and heavy metal free corrosion inhibitors is circulated over the surface at 50null-60null C. The surfactants disperse and unclump the prion-contaminated material. A strong oxidant, preferably peracetic acid, is added to the solution to bring the peracetic acid concentration to 1,000-2,500 ppm. The peracetic acid or other strong oxidant attacks the prions, particularly the unclumped prion strands, deactivating the prions. After rinsing and drying, the surface may be wrapped in a microbe impermeable barrier and subjected to terminal sterilization, such as steam autoclaving.

Abstract translation: 携带被朊病毒感染的材料的表面用碱性清洁溶液清洗，以从表面去除尽可能多的蛋白质材料。 清洁剂是一种碱性清洁剂，其在清洁步骤中侵袭残留在表面上的朊病毒，并且其在表面上去除朊病毒。 清洁溶液排干后，表面活性剂，缓冲剂和无重金属的缓蚀剂溶液在50°-60°C的表面循环。表面活性剂分散并释放朊病毒污染物质。 向该溶液中加入强氧化剂，优选过乙酸，使过乙酸浓度达到1,000-2,500ppm。 过乙酸或其他强氧化剂会侵袭朊病毒，特别是未切开的朊病毒链，使朊病毒失活。 在漂洗和干燥之后，表面可以包裹在微生物不渗透屏障中并进行终端灭菌，例如蒸汽高压灭菌。

公开(公告)号：US20040184950A1

公开(公告)日：2004-09-23

申请号：US10767908

申请日：2004-01-29

Applicant: STERIS INC.

Inventor： Iain F. McVey ,  Victor M. Selig ,  Lewis I. Schwartz ,  Gerald E. McDonnell

IPC: G05B001/00 ,  A61L009/00

CPC classification number: A61L2/208 ,  A61L2/24 ,  A61L9/015 ,  A61L2202/14 ,  A61L2202/25 ,  F24F3/16 ,  F24F2003/1664

Abstract: When microbial contamination is introduced into a room (20*) of an enclosure, such as a building, an HVAC system including supply ductwork (16) and a return ductwork (34) is decontaminated with hydrogen peroxide vapor. A decontamination controller (46) operates controllable baffles (22) at outlet registers (20), temporary controllable baffles (44) at inlet registers (30), and a blower system (10) to circulate hydrogen peroxide vapor from hydrogen peroxide vapor generators (42) through the ductwork in both forward and reverse directions. Further, at least portions of the baffles are closed to create dwell times in which the hydrogen peroxide vapor resides in the ductwork with minimal or turbulent flow.

Abstract translation: 当将微生物污染物引入诸如建筑物的外壳的房间（20 *）中时，包括供应管道系统（16）和回流管道系统（34）的HVAC系统用过氧化氢蒸气去污。 净化控制器（46）在出口寄存器（20），入口寄存器（30）处的临时可控挡板（44）和用于使来自过氧化氢蒸汽发生器的过氧化氢蒸气循环的鼓风机系统（10）上操作可控挡板（22） 42）通过管道系统在正向和反向两个方向。 此外，挡板的至少一部分被关闭以产生停留时间，其中过氧化氢蒸汽驻留在具有最小或湍流的管道系统中。

公开(公告)号：US20030138344A1

公开(公告)日：2003-07-24

申请号：US10280950

申请日：2002-10-25

Applicant: STERIS INC.

Inventor： Thaddeus J. Mielnik ,  David A. Karle ,  Alex D. Biggie ,  William John Thomas Biebesheimer ,  Peter A. Burke ,  Gerald E. McDonnell ,  Chad Rhodes ,  Elaine M. Kopis

IPC: A61L002/00 ,  G05B001/00

CPC classification number: A61L2/208 ,  A61L2/206 ,  A61L2202/23 ,  G01N2001/025

Abstract: A system for handling mail is in the form of a modular facility (10), which is capable of being isolated from the surrounding environment. The modular facility includes an enclosure or sorting area (40) for receiving and sorting incoming mail. A decontamination system (22) receives sorted mail and decontaminates the mail with a antimicrobial gas, such as ethylene oxide. A clean room (32), isolated from the enclosure and spaced from the enclosure by the decontamination system, is used for receiving processed mail from the decontamination system and sorting the mail for distribution. A source (92) of a decontaminant gas, such as vapor hydrogen peroxide, is fluidly connected with the enclosure for supplying the decontaminant gas to the enclosure in the event that the sorting room is contaminated or suspected of being contaminated with a pathogenic biological or chemical agent.

Abstract translation: 用于处理邮件的系统是以与周围环境隔离的模块化设施（10）的形式。 模块化设备包括用于接收和排序收到的邮件的机箱或分拣区域（40）。 净化系统（22）接收排序的邮件，并用抗菌气体如环氧乙烷去除邮件。 用于从净化系统隔离并与隔离物隔离的洁净室（32）用于从净化系统接收处理的邮件并对邮件进行分类。 如分类室被污染或怀疑被病原生物或化学物质污染的情况下，净化气体（例如过氧化氢蒸汽）的源（92）与外壳流体连接，以将净化气体供应到外壳 代理商

公开(公告)号：US20030086820A1

公开(公告)日：2003-05-08

申请号：US10116090

申请日：2002-04-03

Applicant: STERIS INC.

Inventor： Gerald E. McDonnell ,  Kathleen M. Antloga ,  Herbert J. Kaiser

IPC: A61L002/00

CPC classification number: A61L2/186 ,  A61K31/327 ,  A61L2/0082 ,  A61L2/0088 ,  A61L2/14 ,  A61L2/208 ,  A61L2202/122 ,  A61L2202/24 ,  C11D3/3947 ,  C11D11/0023

Abstract: A surface which carries a material which is infected with prions is cleaned with an alkaline cleaning solution to remove as much proteinaceous material as possible from the surface. The solution contains an alkaline cleaning agent which attacks prions remaining on the surface and which attacks prions removed from the surface during the cleaning step. After the cleaning step, the surface is exposed to a strong gaseous oxidant, preferably hydrogen peroxide vapor. The hydrogen peroxide or other strong oxidant attacks the prions, particularly the unclumped prion strands, deactivating the prions.

Abstract translation: 携带被朊病毒感染的材料的表面用碱性清洁溶液清洗，以从表面去除尽可能多的蛋白质材料。 该溶液含有一种碱性清洁剂，其在清洁步骤中侵蚀残留在表面上的朊病毒，并且会从表面去除朊病毒。 在清洁步骤之后，表面暴露于强气体氧化剂，优选过氧化氢蒸气。 过氧化氢或其他强氧化剂会攻击朊病毒，特别是未切开的朊病毒链，使朊病毒失活。