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公开(公告)号：US08394809B2
公开(公告)日：2013-03-12
申请号：US12913948
申请日：2010-10-28
申请人： Steven J. Coats , Yue-Mei Zhang , Shu-Chen Lin , Li Liu , Tamara A. Miskowski , Scott L. Dax , Henry Breslin , Bart L. De Corte , Wei He
发明人： Steven J. Coats , Yue-Mei Zhang , Shu-Chen Lin , Li Liu , Tamara A. Miskowski , Scott L. Dax , Henry Breslin , Bart L. De Corte , Wei He
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D239/52 , A61K31/506 , C07D239/28 , C07D239/34 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, Y, R2, R3, and Ra are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R1，Y，R2，R3和Ra在本文中定义。
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公开(公告)号：US20110105455A1
公开(公告)日：2011-05-05
申请号：US12913948
申请日：2010-10-28
申请人： STEVEN J. COATS , Yue-Mei Zhang , Shu-Chen Lin , Li Liu , Tamara A. Miskowski , Scott L. Dax , Henry Breslin , Bart L. De Corte , Wei He
发明人： STEVEN J. COATS , Yue-Mei Zhang , Shu-Chen Lin , Li Liu , Tamara A. Miskowski , Scott L. Dax , Henry Breslin , Bart L. De Corte , Wei He
IPC分类号： A61K31/506 , C07D403/12 , C07D401/12 , C07D413/12 , C07D417/12 , C07D401/14 , A61K31/505 , A61K31/5377 , A61P29/00 , A61P25/04 , A61P25/16 , A61P25/30 , A61P25/32 , A61P1/12 , A61P9/00 , A61P15/00 , A61P11/00
CPC分类号： C07D239/52 , A61K31/506 , C07D239/28 , C07D239/34 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, Y, R2, R3, and Ra are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R1，Y，R2，R3和Ra在本文中定义。
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公开(公告)号：US08513271B2
公开(公告)日：2013-08-20
申请号：US12913966
申请日：2010-10-28
申请人： Steven J. Coats , Haiyan Bian , Peter J. Connolly , Gilles Bignan , Chaozhong Cai , Scott L. Dax , Bart L. DeCorte , Shu-Chen Lin , Li Liu , Mark J. Macielag , Philip M. Pitis , Yue-Mei Zhang , Bin Zhu , Wei He
发明人： Steven J. Coats , Haiyan Bian , Peter J. Connolly , Gilles Bignan , Chaozhong Cai , Scott L. Dax , Bart L. DeCorte , Shu-Chen Lin , Li Liu , Mark J. Macielag , Philip M. Pitis , Yue-Mei Zhang , Bin Zhu , Wei He
IPC分类号： A01N43/54
CPC分类号： C07D239/47 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, and L, A, and Ra are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R1，R2，R3和L，A和Ra在本文中定义。
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公开(公告)号：US08399454B2
公开(公告)日：2013-03-19
申请号：US12765254
申请日：2010-04-22
申请人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
发明人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/496 , A61K31/55 , A61K31/5377 , C07D205/04 , C07D295/12 , C07D401/12 , C07D403/04 , C07D409/06 , C07D413/12
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
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公开(公告)号：US20110015171A1
公开(公告)日：2011-01-20
申请号：US12765420
申请日：2010-04-22
申请人： Haiyan BIAN , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
发明人： Haiyan BIAN , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/397 , C07D401/14 , C07D403/04 , C07D417/14 , C07D409/14 , A61P29/00 , A61P25/06 , A61P19/00 , A61P17/00
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式（I）表示如下：其中Y，Z，R 1和S在本文中定义。
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公开(公告)号：US20110015170A1
公开(公告)日：2011-01-20
申请号：US12765254
申请日：2010-04-22
申请人： Haiyan BIAN , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
发明人： Haiyan BIAN , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/397 , C07D403/04 , C07D417/14 , C07D403/14 , A61P29/00 , A61P25/06 , A61P19/02 , A61P1/00
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
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公开(公告)号：US20100324014A1
公开(公告)日：2010-12-23
申请号：US12765103
申请日：2010-04-22
申请人： Haiyan BIAN , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
发明人： Haiyan BIAN , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/496 , C07D403/04 , C07D417/14 , A61K31/541 , A61P29/00
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
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公开(公告)号：US20100324011A1
公开(公告)日：2010-12-23
申请号：US12765018
申请日：2010-04-22
申请人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
发明人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/496 , C07D403/04 , C07D417/14 , C07D409/14 , C07D401/14 , C07D403/14 , A61P29/00
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
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公开(公告)号：US08362000B2
公开(公告)日：2013-01-29
申请号：US12765420
申请日：2010-04-22
申请人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
发明人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/496 , A61K31/5377 , C07D205/04 , C07D401/12 , C07D403/04 , C07D409/06 , C07D413/12
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
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公开(公告)号：US20100324012A1
公开(公告)日：2010-12-23
申请号：US12765048
申请日：2010-04-22
申请人： Haiyan BIAN , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
发明人： Haiyan BIAN , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/496 , C07D403/04 , C07D417/14 , C07D409/14 , C07D401/14 , C07D403/14 , A61P29/00
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
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