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公开(公告)号：US09181529B2
公开(公告)日：2015-11-10
申请号：US13276832
申请日：2011-10-19
申请人： Steven Kattman , Wen Bo Wang , Peter Fuhrken , Nathan Meyer , Matthew George , Casey Stankewicz
发明人： Steven Kattman , Wen Bo Wang , Peter Fuhrken , Nathan Meyer , Matthew George , Casey Stankewicz
CPC分类号： C12N5/0696 , C12N5/0607 , C12N2503/00 , C12N2506/00
摘要： Methods and composition for differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including screening of optimal differentiation conditions for a selected stem cell clone in a selected batch of culture medium and use of the determined optimal condition for differentiation into a specific cell lineage.
摘要翻译： 提供了多能干细胞分化的方法和组成。 例如，在某些方面，包括筛选所选批次的培养基中所选干细胞克隆的最佳分化条件的方法，以及使用确定的最佳条件分化成特定细胞谱系。
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公开(公告)号：US20120129211A1
公开(公告)日：2012-05-24
申请号：US13276832
申请日：2011-10-19
申请人： STEVEN KATTMAN , Wen Bo Wang , Peter Fuhrken , Nathan Meyer , Matthew George , Casey Stankewicz
发明人： STEVEN KATTMAN , Wen Bo Wang , Peter Fuhrken , Nathan Meyer , Matthew George , Casey Stankewicz
CPC分类号： C12N5/0696 , C12N5/0607 , C12N2503/00 , C12N2506/00
摘要： Methods and composition for differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including screening of optimal differentiation conditions for a selected stem cell clone in a selected batch of culture medium and use of the determined optimal condition for differentiation into a specific cell lineage.
摘要翻译： 提供了多能干细胞分化的方法和组成。 例如，在某些方面，包括筛选所选批次的培养基中所选干细胞克隆的最佳分化条件的方法，以及使用确定的最佳条件分化成特定细胞谱系。
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公开(公告)号：US20110097799A1
公开(公告)日：2011-04-28
申请号：US12907714
申请日：2010-10-19
申请人： Casey Stankewicz , Matt Riley , Nathaniel Beardsley , Wen Bo Wang , Peter Fuhrken , Steven Kattman
发明人： Casey Stankewicz , Matt Riley , Nathaniel Beardsley , Wen Bo Wang , Peter Fuhrken , Steven Kattman
CPC分类号： C12N5/0657 , A61K48/00 , C07H21/04 , C07K14/475 , C07K14/50 , C12N5/0606 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/12 , C12N2501/155 , C12N2501/16 , C12N2501/48 , C12N2501/70 , C12N2501/727 , C12N2506/02 , C12N2506/45 , C12N2509/00 , C12N2510/00
摘要： Methods and composition for the production of cardiomyocytes from differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including differentiating pluripotent stem cells in a large volume of suspension culture in the presence of ROCK inhibitors are described. In further aspects, methods for differentiation of stem cells into cardiomyocytes that overcome variability between different stem cell clones and different batch of culture medium are provided.
摘要翻译： 提供了从多能干细胞分化产生心肌细胞的方法和组成。 例如，在某些方面，描述了在ROCK抑制剂存在下将大量悬浮培养物中的多能干细胞分化的方法。 在另外的方面，提供了将干细胞分化为心肌细胞的方法，其克服不同干细胞克隆和不同批次的培养基之间的变异性。
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公开(公告)号：US08415155B2
公开(公告)日：2013-04-09
申请号：US12907714
申请日：2010-10-19
申请人： Casey Stankewicz , Matt Riley , Nathaniel Beardsley , Wen Bo Wang , Peter Fuhrken , Steven Kattman
发明人： Casey Stankewicz , Matt Riley , Nathaniel Beardsley , Wen Bo Wang , Peter Fuhrken , Steven Kattman
CPC分类号： C12N5/0657 , A61K48/00 , C07H21/04 , C07K14/475 , C07K14/50 , C12N5/0606 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/12 , C12N2501/155 , C12N2501/16 , C12N2501/48 , C12N2501/70 , C12N2501/727 , C12N2506/02 , C12N2506/45 , C12N2509/00 , C12N2510/00
摘要： Methods and composition for the production of cardiomyocytes from differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including differentiating pluripotent stem cells in a large volume of suspension culture in the presence of ROCK inhibitors are described. In further aspects, methods for differentiation of stem cells into cardiomyocytes that overcome variability between different stem cell clones and different batch of culture medium are provided.
摘要翻译： 提供了从多能干细胞分化产生心肌细胞的方法和组成。 例如，在某些方面，描述了在ROCK抑制剂存在下将大量悬浮培养物中的多能干细胞分化的方法。 在另外的方面，提供了将干细胞分化为心肌细胞的方法，其克服不同干细胞克隆和不同批次的培养基之间的变异性。
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