公开(公告)号：US09932305B2

公开(公告)日：2018-04-03

申请号：US14371333

申请日：2013-01-08

Applicant: STUDIENGESELLSCHAFT KOHLE MBH

Inventor： Benjamin List ,  Ilija Coric ,  Saihu Liao

IPC: C07C315/02 ,  B01J31/02 ,  C07B53/00 ,  C07B45/04 ,  C07D493/10 ,  C07F9/6571 ,  C07F9/6574

CPC classification number: C07C315/02 ,  B01J31/0258 ,  B01J31/0264 ,  B01J2231/70 ,  C07B45/04 ,  C07B53/00 ,  C07B2200/07 ,  C07C2601/14 ,  C07C2602/08 ,  C07D493/10 ,  C07F9/657154 ,  C07F9/65744 ,  C07C317/14 ,  C07C317/22 ,  C07C317/12 ,  C07C317/04 ,  C07C317/44

Abstract: The present invention relates to a process for the asymmetric oxidation of nucleophilic organic compounds, particularly metal-free, with peroxide compounds in the presence of a chiral Brønsted acid catalyst. In one detail, the present invention relates to a process for enantioselective sulfoxidation of thiocompounds with peroxide compounds in the presence of a chiral imidodiphosphate catalyst. In another detail, the present invention relates to a process for enantioselective sulfoxidation of thiocompounds with peroxide compounds in the presence of a chiral phosphoric acid catalyst.

公开(公告)号：US20150005527A1

公开(公告)日：2015-01-01

申请号：US14371333

申请日：2013-01-08

Applicant: STUDIENGESELLSCHAFT KOHLE MBH

Inventor： Benjamin List ,  Ilija Coric ,  Saihu Liao

IPC: C07C315/02 ,  B01J31/02

CPC classification number: C07C315/02 ,  B01J31/0258 ,  B01J31/0264 ,  B01J2231/70 ,  C07B45/04 ,  C07B53/00 ,  C07B2200/07 ,  C07C2601/14 ,  C07C2602/08 ,  C07D493/10 ,  C07F9/657154 ,  C07F9/65744 ,  C07C317/14 ,  C07C317/22 ,  C07C317/12 ,  C07C317/04 ,  C07C317/44

Abstract: The present invention relates to a process for the asymmetric oxidation of nucleophilic organic compounds, particularly metal-free, with peroxide compounds in the presence of a chiral Brønsted acid catalyst. In one detail, the present invention relates to a process for enantioselective sulfoxidation of thiocompounds with peroxide compounds in the presence of a chiral imidodiphosphate catalyst. In another detail, the present invention relates to a process for enantioselective sulfoxidation of thiocompounds with peroxide compounds in the presence of a chiral phosphoric acid catalyst.

Abstract translation: 本发明涉及在手性布朗斯台德酸催化剂存在下用过氧化物化合物对亲核有机化合物，特别是不含金属的不对称氧化的方法。 一方面，本发明涉及一种在手性酰亚胺二磷酸盐催化剂存在下用过氧化物化合物对硫代化合物进行对映选择性磺基氧化的方法。 另一个细节，本发明涉及在手性磷酸催化剂存在下用过氧化物化合物对硫代化合物进行对映选择性磺基氧化的方法。