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    Formation of N-Protected bis-3,6-(4-aminoalkyl)-2,5,diketopiperazine
    1.
    发明申请
    Formation of N-Protected bis-3,6-(4-aminoalkyl)-2,5,diketopiperazine 审中-公开

    公开(公告)号：US20160347721A1

    公开(公告)日：2016-12-01

    申请号：US15237427

    申请日：2016-08-15

    申请人： Mannkind Corp

    发明人： John J. Freeman ,  Adrienne Stamper ,  Melissa Heitmann

    IPC分类号： C07D241/08

    CPC分类号： C07D241/08 ,  B01J31/0225 ,  B01J31/0258 ,  B01J31/0259 ,  B01J2231/40

    摘要： The disclosed embodiments detail improved methods for the synthesis of diketopiperazines from amino acids. In particular improved methods for the cyclocondensation and purification of N-protected 3,6-(aminoalkyl)-2,5-diketopiperazines from N-protected amino acids. Disclosed embodiments describe methods for the synthesis of 3,6-bis-[N-protected aminoalkyl]-2,5-diketopiperazine comprising heating a mixture of an amino acid in the presence of a catalyst in an organic solvent. The catalyst is selected from the group comprising sulfuric acid, phosphoric acid, p-toluenesulfonic acid, 1-propylphosphonic acid cyclic anhydride, tributyl phosphate, phenyl phosphonic acid and phosphorous pentoxide among others. The solvent is selected from the group comprising: dimethylacetamide, N-methyl-2-pyrrolidone, diglyme, ethyl glyme, proglyme, ethyldiglyme, m-cresol, p-cresol, o-cresol, xylenes, ethylene glycol and phenol among others.

    Formation of N-Protected bis-3,6-(4-aminoalkyl)-2,5,diketopiperazine
    2.
    发明申请
    Formation of N-Protected bis-3,6-(4-aminoalkyl)-2,5,diketopiperazine 有权
    形成N-保护的双-3,6-（4-氨基烷基）-2,5，二酮哌嗪

    公开(公告)号：US20150073149A1

    公开(公告)日：2015-03-12

    申请号：US14543464

    申请日：2014-11-17

    申请人： Mannkind Corp

    发明人： John J. Freeman ,  Adrienne Stamper ,  Melissa Heitmann

    IPC分类号： C07D241/08

    CPC分类号： C07D241/08 ,  B01J31/0225 ,  B01J31/0258 ,  B01J31/0259 ,  B01J2231/40

    摘要： The disclosed embodiments detail improved methods for the synthesis of diketopiperazines from amino acids. In particular improved methods for the cyclocondensation and purification of N-protected 3,6-(aminoalkyl)-2,5-diketopiperazines from N-protected amino acids. Disclosed embodiments describe methods for the synthesis of 3,6-bis-[N-protected aminoalkyl]-2,5-diketopiperazine comprising heating a mixture of an amino acid in the presence of a catalyst in an organic solvent. The catalyst is selected from the group comprising sulfuric acid, phosphoric acid, p-toluenesulfonic acid, 1-propylphosphonic acid cyclic anhydride, tributyl phosphate, phenyl phosphonic acid and phosphorous pentoxide among others. The solvent is selected from the group comprising: dimethylacetamide, N-methyl-2-pyrrolidone, diglyme, ethyl glyme, proglyme, ethyldiglyme, m-cresol, p-cresol, o-cresol, xylenes, ethylene glycol and phenol among others.

    摘要翻译： 所公开的实施方案详细描述了从氨基酸合成二酮哌嗪的改进方法。 特别是用于由N-保护的氨基酸环化缩合和纯化N-保护的3,6-（氨基烷基）-2,5-二酮哌嗪的改进方法。 公开的实施方案描述了合成3,6-双[N-保护的氨基烷基] -2,5-二酮哌嗪的方法，包括在催化剂存在下在有机溶剂中加热氨基酸的混合物。 催化剂选自硫酸，磷酸，对甲苯磺酸，1-丙基膦酸环状酸酐，磷酸三丁酯，苯基膦酸和五氧化二磷等。 溶剂选自二甲基乙酰胺，N-甲基-2-吡咯烷酮，二甘醇二甲醚，甘醇二甲醚，丙二醇，乙基二甘醇二甲醚，间甲酚，对甲酚，邻甲酚，二甲苯，乙二醇和苯酚等。

    PROCESS FOR PRODUCING HYDROXYALKYLTRIETHYLENEDIAMINE, AND CATALYST COMPOSITION FOR THE PRODUCTION OF POLYURETHANE RESIN USING IT
    4.
    发明申请
    PROCESS FOR PRODUCING HYDROXYALKYLTRIETHYLENEDIAMINE, AND CATALYST COMPOSITION FOR THE PRODUCTION OF POLYURETHANE RESIN USING IT 审中-公开
    用于生产羟基甲基氯乙烯的方法，以及使用它生产聚氨酯树脂的催化剂组合物

    公开(公告)号：US20110077376A1

    公开(公告)日：2011-03-31

    申请号：US12995332

    申请日：2009-05-29

    申请人： Katsumi Tokumoto ,  Takao Suzuki ,  Hiroyuki Kiso ,  Yoshihiro Takahashi ,  Yutaka Tamano

    发明人： Katsumi Tokumoto ,  Takao Suzuki ,  Hiroyuki Kiso ,  Yoshihiro Takahashi ,  Yutaka Tamano

    IPC分类号： C08G18/20 ,  B01J31/18

    CPC分类号： C08G18/6688 ,  B01J25/02 ,  B01J27/16 ,  B01J31/0258 ,  B01J31/0259 ,  B01J31/0261 ,  B01J2231/40 ,  C08G18/1825 ,  C08G18/2027 ,  C08G18/4816 ,  C08G2101/0008 ,  C08G2101/005 ,  C08G2101/0083

    摘要： To provide a process for producing a hydroxyalkyltriethylenediamine or hydroxytriethylenediamine simply and in a small number of steps without requiring multi-stage reaction steps; a novel catalyst composition whereby a polyurethane product can be obtained with good productivity and good moldability without bringing about odor problems or environmental problems; and a process for producing a polyurethane resin using the catalyst composition.For example, a hydroxyalkyltriethylenediamine or hydroxytriethylenediamine is produced by subjecting a mono-substituted dihydroxyalkylpiperazine and/or a di-substituted hydroxyalkylpiperazine to an intramolecular dehydration condensation reaction in the presence of an acid catalyst.Further, for example, a polyurethane resin is produced by using a catalyst composition which comprises a hydroxyalkyltriethylenediamine or hydroxytriethylenediamine (A), and an amine compound (B) having, in its molecule, one or more substituents selected from the group consisting of a hydroxy group, a primary amino group and a secondary amino group, or a tertiary amine compound (C) having a value of [blowing reaction rate constant/gelling reaction rate constant] of at least 0.5.

    摘要翻译： 提供一种简单且少量步骤生产羟基烷基三亚乙基二胺或羟基三亚乙基二胺的方法，而不需要多级反应步骤; 可以以高生产率和良好的成型性获得聚氨酯产品而不引起气味问题或环境问题的新型催化剂组合物; 以及使用该催化剂组合物制造聚氨酯树脂的方法。 例如，羟基烷基三亚乙基二胺或羟基三亚乙基二胺通过在酸催化剂的存在下使单取代的二羟基烷基哌嗪和/或二取代的羟烷基哌嗪进行分子内脱水缩合反应来制备。 此外，例如，通过使用包含羟烷基三亚乙基二胺或羟基三亚乙基二胺（A）的催化剂组合物和在其分子中具有一个或多个选自羟基 或叔氨基和仲氨基，或具有至少为0.5的[发泡反应速度常数/凝胶化反应速率常数]值的叔胺化合物（C）。

    Asymmetric synthesis catalyst based on chiral brsnsted acid and method of asymmetric synthesis with the catalyst
    5.
    发明申请
    Asymmetric synthesis catalyst based on chiral brsnsted acid and method of asymmetric synthesis with the catalyst 有权
    基于手性戊二酸的不对称合成催化剂和催化剂不对称合成方法

    公开(公告)号：US20060276329A1

    公开(公告)日：2006-12-07

    申请号：US10554369

    申请日：2004-04-20

    申请人： Takahiko Akiyama

    发明人： Takahiko Akiyama

    IPC分类号： B01J31/00 ,  C07F9/02

    CPC分类号： B01J31/0258 ,  B01J2231/323 ,  B01J2231/326 ,  B01J2231/346 ,  B01J2231/44 ,  C07B53/00 ,  C07C227/10 ,  C07F9/65744

    摘要： A compound usable as an asymmetric synthesis catalyst which can be easily synthesized without using any metal such as a lanthanoid group element; a method of asymmetric synthesis with the compound; and a chiral compound obtained by the asymmetric synthesis method. A Broensted acid is used as a catalyst in asymmetric synthesis, the chiral Broensted acid being represented by formula (1) below or formula (3) below. The asymmetric synthesis method employs the catalyst. Asymmetric synthesis with the catalyst gives a chiral compound.

    摘要翻译： 可用作不对称合成催化剂的化合物，其可以容易地合成而不使用任何金属如镧系元素元素; 与该化合物不对称合成的方法; 和通过不对称合成法获得的手性化合物。 Broensted酸用作不对称合成中的催化剂，手性Broensted酸由下式（1）或下式（3）表示。 不对称合成方法采用催化剂。 与催化剂的不对称合成得到手性化合物。

    Process for regenerating and rejuvenating additive-based catalysts
    8.
    发明申请
    Process for regenerating and rejuvenating additive-based catalysts 有权
    再生和再生添加剂催化剂的方法

    公开(公告)号：US20030104926A1

    公开(公告)日：2003-06-05

    申请号：US10289058

    申请日：2002-11-06

    发明人： Sonja Eijsbouts ,  Franciscus Wilhelmus Houtert ,  Marcel Adriaan Jansen ,  Tetsuro Kamo ,  Frans Lodewijk Plantenga

    IPC分类号： B01J038/50 ,  C10G047/00

    CPC分类号： C10G45/08 ,  B01J21/04 ,  B01J23/94 ,  B01J31/0202 ,  B01J31/0204 ,  B01J31/0205 ,  B01J31/0237 ,  B01J31/0258 ,  B01J31/0271 ,  B01J31/06 ,  B01J31/1616 ,  B01J31/28 ,  B01J31/34 ,  B01J31/4015 ,  B01J31/403 ,  B01J31/4092 ,  B01J38/12 ,  B01J38/20 ,  B01J38/52 ,  B01J38/62 ,  B01J2231/641 ,  C10G45/04 ,  Y10S502/514

    摘要： The present invention pertains to a process for regenerating and rejuvenating an additive-based hydrotreating catalyst containing Group VIB and Group VIII hydrogenation metals. The process comprises the steps of regenerating the catalyst by contacting it with an oxygen-containing gas at a maximum temperature of 500null C., followed by rejuvenating the catalyst by contacting it with an organic additive comprising an organic compound, other than a compound that the catalyst is contacted with in the course of its use as a catalyst prior to regeneration and rejuvenation. The organic additive is incorporated into the catalyst. If necessary, the catalyst may then be dried at such a temperature that at least 50% of the additive is maintained in the catalyst. The process according to the invention makes it possible to restore the activity of a used additive-based hydrotreating catalyst to its original level, or even to improve it to above that level.

    摘要翻译： 本发明涉及一种用于再生和再生含有VIB族和VIII族氢化金属的基于添加剂的加氢处理催化剂的方法。 该方法包括通过使催化剂与最高温度为500℃的含氧气体接触来再生催化剂，然后通过使催化剂与含有有机化合物的有机添加剂接触来使催化剂再生，所述有机添加剂除了 在再生和再生之前催化剂在使用过程中与催化剂接触。 将有机添加剂并入催化剂中。 如果需要，然后可以在至少50％的添加剂保持在催化剂中的温度下干燥催化剂。 根据本发明的方法使得可以将使用的基于添加剂的加氢处理催化剂的活性恢复到其原始水平，或甚至将其提高到高于该水平。

    Catalyst composition and process therewith
    9.
    发明申请
    Catalyst composition and process therewith 有权
    催化剂组成及其工艺

    公开(公告)号：US20020098972A1

    公开(公告)日：2002-07-25

    申请号：US09770116

    申请日：2001-01-24

    发明人： Jiwen F. Duan

    IPC分类号： B01J031/00

    CPC分类号： B01J31/0258 ,  B01J31/0212 ,  B01J31/068 ,  B01J31/1845 ,  B01J31/2208 ,  B01J2531/46 ,  C08G63/85

    摘要： A composition that can be used as a catalyst is disclosed. The composition comprises, or is produced by combining, a titanium compound, a glycol, a phosphorus compound, and optionally water. Also disclosed is a process that can be used for producing a polyester. The process comprises contacting, in the presence of a catalyst composition, a carbonyl compound and an alcohol under a condition suitable for esterification, transesterification, or polymerization. The catalyst composition comprises, or is produced by combining, a titanium compound, a glycol, a phosphorus compound, and optionally water.

    摘要翻译： 公开了可用作催化剂的组合物。 组合物包含钛化合物，二醇，磷化合物和任选的水组合，或通过组合制备。 还公开了可用于生产聚酯的方法。 该方法包括在适于酯化，酯交换或聚合的条件下，在催化剂组合物存在下使羰基化合物和醇接触。 催化剂组合物包含或通过组合钛化合物，二醇，磷化合物和任选的水而制备。