公开(公告)号：US20190282478A1

公开(公告)日：2019-09-19

申请号：US16301854

申请日：2016-10-11

申请人： SYMRISE AG

发明人： Manuel PESARO ,  Bernd HÖLSCHER ,  Benoit JOIN

IPC分类号： A61K8/37 ,  A61K8/42 ,  A61K8/49 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q19/10 ,  A61Q17/00 ,  A61K8/04 ,  A61K8/06

摘要： The present invention is the use of a compound of formula (I) or a (pharmaceutically) acceptable salt thereof, wherein (a) X denotes CH═CH or CZ1=CZ2, wherein if Z1 is H then Z2 denotes a radical selected from the group consisting of OH, NH2, NHMe, NMe2, OMe and OEt and if Z2 is H then Z1 denotes a radical selected from the group consisting of OH, NH2, NHMe, NMe2, OMe and OEt, Y denotes a radical selected from the group consisting of NH2, NHMe, NMe2, NHEt, O—(CH2)n—OH, wherein n is 2 to 5 and R denotes a radical selected from the group consisting of H, OH, Me, Et, OMe, OEt, NH2, NHMe, NMe2, NHEt and NEt2, or (b) X denotes O, Y denotes a radical selected from the group consisting of NH2, NHMe, NMe2, NHEt, O—(CH2)n—OH and OMe, wherein n is 2 to 5 and R denotes H, OH, Me, Et, OMe, OEt, NH2, NHMe, NMe2, NHEt, NEt2 as anti-microbial agent as well as to composition comprising said agent.

公开(公告)号：US20210045983A1

公开(公告)日：2021-02-18

申请号：US17042263

申请日：2019-03-29

申请人： SYMRISE AG

发明人： Dominik STUHLMANN ,  Ann-Christin WESELOH ,  Nicole TITZE ,  Sabine LANGE ,  Sebastian BRUNCKE ,  Benoit JOIN ,  Gabriele VIELHABER ,  Marielle LE MAIRE ,  Karima BENAISSI

IPC分类号： A61K8/37 ,  A61Q17/04 ,  A61Q19/00 ,  A61K31/225 ,  A61K31/232 ,  A61Q19/08 ,  A61K31/355 ,  A61K31/357 ,  A61K36/9068 ,  A61K36/886 ,  A61K31/22 ,  A61K31/047 ,  A61K31/23 ,  A61K31/198 ,  A61P17/02 ,  A61K31/01 ,  A61K36/28

摘要： The present invention relates to novel cosmetic and therapeutic uses of one or more compounds of the general formula (1) as described herein. Furthermore, the present invention relates to compositions (products or, respectively, formulations), in particular for topical administration, preferably cosmetic or pharmaceutical compositions, comprising or consisting of compound(s) of formula (1) and one or more cosmetically and/or pharmaceutically acceptable carriers. The present invention also relates to novel uses of such N compositions according to the invention.

公开(公告)号：US20190167553A1

公开(公告)日：2019-06-06

申请号：US16324166

申请日：2016-08-09

申请人： SYMRISE AG

发明人： Benoit JOIN ,  Michael BACKES ,  Arnold MACHINEK ,  Ulrike SIMCHEN ,  Jenny WEISSBRODT ,  Jens FAHLE

IPC分类号： A61K8/42 ,  A61K8/92 ,  A61K8/34 ,  A61K8/37 ,  A61Q5/02 ,  A61Q19/10

摘要： Mixtures comprising a selected cooling active ingredient (E)-3-benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide and at least one other substance which acts as a solvent for (E)-3-benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide, wherein the substance is selected form the group consisting of benzyl benzoate, diethyl succinate, triethyl citrate, triacetin, ethanol, peppermint oil, anethol, optamint, propylene glycol, further cooling active ingredients or mixtures thereof.

公开(公告)号：US20230059747A1

公开(公告)日：2023-02-23

申请号：US17615894

申请日：2019-06-13

申请人： SYMRISE AG

发明人： Benoit JOIN ,  Ulrike SIMCHEN ,  Hubert LOGES ,  Arnold MACHINEK

IPC分类号： A61K8/37 ,  A61K8/33 ,  A61Q11/00 ,  A61Q19/00 ,  A23G4/12 ,  A23G3/38 ,  A23G3/36

摘要： Suggested is a cooling preparation comprising phenylalkenals and homovanillic acid esters.

公开(公告)号：US20190282477A1

公开(公告)日：2019-09-19

申请号：US16301233

申请日：2016-05-14

申请人： Symrise AG

发明人： Sven SIEGEL ,  Arnold MACHINEK ,  Benoit JOIN

IPC分类号： A61K8/37 ,  A61K31/05 ,  A61K31/222 ,  A61K8/34 ,  A61K9/68 ,  A61Q11/00 ,  A61K31/085

摘要： The invention relates to aroma preparations that contain (a) a compound of the formula (I) in which R1 represents a linear or branched, saturated or unsaturated hydrocarbon group with 1 to 4 carbon atoms, R2 represents hydrogen or a hydroxyl group and R3 represents hydrogen, a methyl or methoxy group, or an essential oil containing one or more compounds of the formula (I) and at least one menthol compound.