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公开(公告)号：US20170315112A1
公开(公告)日：2017-11-02
申请号：US15650414
申请日：2017-07-14
Applicant: SYSMEX CORPORATION
Inventor： Keiko YOSHIKAWA , Amane HARADA , Katsuhiro MURAKAMI , Maria KIRIYAMA , Keiko MIWA , Takuya KUBO
Abstract: The present invention relates to a method for measuring the cholesterol uptake capacity of lipoproteins. The present invention also relates to a reagent kit for measuring the cholesterol uptake capacity of lipoproteins. The present invention further relates to a tagged cholesterol which can be used in the method and the reagent kit.
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公开(公告)号：US20230296634A1
公开(公告)日：2023-09-21
申请号：US18183369
申请日：2023-03-14
Applicant: SYSMEX CORPORATION
Inventor： Takuya KUBO , Youichi NISHIKAWA , Shinnosuke UNO , Amane HARADA , Katsuhiro MURAKAMI , Jeeeun KIM , Maria KIRIYAMA , Keiko MIWA
IPC: G01N33/92 , C12Q1/60 , G01N33/543 , G01N33/58
CPC classification number: G01N33/92 , C12Q1/60 , G01N33/543 , G01N33/58 , G01N2333/775 , G01N2405/00
Abstract: Disclosed is a method for measuring sterol in lipoprotein, comprising: forming a complex by contacting lipoprotein in a sample, a tagged sterol, and a first capture body that specifically binds to the tag and has a labeling substance with each other, the complex comprising the lipoprotein comprising the tagged sterol and the first capture body; and detecting a signal generated by the labeling substance comprised in the complex, wherein in the tagged sterol, the tag is added to C3 position of a sterol skeleton.
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公开(公告)号：US20200018755A1
公开(公告)日：2020-01-16
申请号：US16584114
申请日：2019-09-26
Applicant: SYSMEX CORPORATION
Inventor： Katsuhiro MURAKAMI , Takuya IINO , Keiko MIWA , Xiaoling PENG , Naoya SAIKI
IPC: G01N33/577 , G01N1/38 , C07K16/18 , C07J43/00
Abstract: Provided is a monoclonal antibody or antigen-binding fragment thereof which binds to a peptide consisting of 51st to 110th amino acid sequence or a peptide consisting of 201st to 267th amino acid sequence of an amino acid sequence of SEQ ID NO: 1, and is capable of binding to high-density lipoproteins of (1) to (3) below; (1) high-density lipoprotein that is oxidatively modified, (2) high-density lipoprotein that is not oxidatively modified, and (3) high-density lipoprotein incorporating labeled cholesterol.
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Patent Agency Ranking
公开(公告)号：US20210003562A1
公开(公告)日：2021-01-07
申请号：US17023946
申请日：2020-09-17
Applicant: SYSMEX CORPORATION
Inventor： Keiko YOSHIKAWA , Amane HARADA , Katsuhiro MURAKAMI , Maria KIRIYAMA , Keiko MIWA , Takuya KUBO
Abstract: The present invention relates to a method for measuring the cholesterol uptake capacity of lipoproteins. The present invention also relates to a reagent kit for measuring the cholesterol uptake capacity of lipoproteins. The present invention further relates to a tagged cholesterol which can be used in the method and the reagent kit.
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公开(公告)号：US20210356454A1
公开(公告)日：2021-11-18
申请号：US17388223
申请日：2021-07-29
Applicant: SYSMEX CORPORATION
Inventor： Masatoshi YANAGIDA , Keiko MIWA , Yuma OKA
Abstract: Disclosed is a method for measuring an immunostimulatory response of an immune cell, including (i) bringing a measurement target immune cell into contact with an immunostimulator, (ii) forming a contact surface with a substance different from the measurement target immune cell on the measurement target immune cell, (iii) bringing the measurement target immune cell into contact with a capturing body that binds to a surface antigen on the contact surface and is capable of generating an optical signal, (iv) detecting the optical signal generated from the capturing body, and (v) determining whether or not the measurement target immune cell from which the contact surface has been eliminated before detecting the optical signal has an immunostimulatory response, based on the detected optical signal.
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公开(公告)号：US20210270812A1
公开(公告)日：2021-09-02
申请号：US17323444
申请日：2021-05-18
Applicant: SYSMEX CORPORATION
Inventor： Yuma OKA , Masatoshi YANAGIDA , Keiko MIWA
IPC: G01N33/50
Abstract: Disclosed is a method for analyzing immune cells, comprising the steps of mixing whole blood containing immune cells with an immunostimulatory factor in vitro and labeling target molecules of the immune cells, and a step of acquiring information on localization of the target molecules on the immune cells by detecting the label.
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公开(公告)号：US20210231692A1
公开(公告)日：2021-07-29
申请号：US17154132
申请日：2021-01-21
Applicant: SYSMEX CORPORATION
Inventor： Amane HARADA , Katsuhiro MURAKAMI , Keiko MIWA , Elnaz NAKHAEI
IPC: G01N33/92
Abstract: Disclosed is a method for obtaining information about cognitive function of a subject, comprising contacting lipoprotein in a blood sample of a subject with a labeled lipid and measuring the labeled lipid incorporated into the lipoprotein, wherein the obtained measured value is an indicator of cognitive impairment.
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公开(公告)号：US20160109469A1
公开(公告)日：2016-04-21
申请号：US14882812
申请日：2015-10-14
Applicant: SYSMEX CORPORATION
Inventor： Amane HARADA , Katsuhiro MURAKAMI , Maria KIRIYAMA , Keiko YOSHIKAWA , Keiko MIWA
IPC: G01N33/92
CPC classification number: G01N33/92 , G01N2333/775 , G01N2405/00 , G01N2800/044
Abstract: Provided is a method of measuring a lipoprotein's capacity to accept cholesterol including the steps of: bringing a lipoprotein in a sample into contact with labeled cholesterol to incorporate the labeled cholesterol into the lipoprotein; bringing the lipoprotein having the labeled cholesterol into contact with an antibody that binds to a lipoprotein to form a complex of the lipoprotein and the antibody; and measuring the label incorporated into the complex.
Abstract translation: 提供了测量脂蛋白接受胆固醇的能力的方法，包括以下步骤：将样品中的脂蛋白与标记的胆固醇接触以将标记的胆固醇并入脂蛋白; 使具有标记胆固醇的脂蛋白与结合脂蛋白的抗体接触以形成脂蛋白和抗体的复合物; 并测量结合到复合物中的标签。
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