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    NOVEL FLUORINE-CONTAINING COPOLYMER AND MEMBRANE
    1.
    发明申请
    NOVEL FLUORINE-CONTAINING COPOLYMER AND MEMBRANE 审中-公开
    新型含氟聚合物和膜

    公开(公告)号：US20120148818A1

    公开(公告)日：2012-06-14

    申请号：US13362630

    申请日：2012-01-31

    申请人： Safir L. ADAM ,  Song Li ,  Shinji Okada ,  Nobuyuki Kasahara ,  Katsuya Ueno ,  Yoshitomi Morizawa ,  Takashi Okazoe

    发明人： Safir L. ADAM ,  Song Li ,  Shinji Okada ,  Nobuyuki Kasahara ,  Katsuya Ueno ,  Yoshitomi Morizawa ,  Takashi Okazoe

    IPC分类号： C08F214/24 ,  B32B27/28 ,  C09D127/12

    CPC分类号： C08F214/24 ,  C08F214/242

    摘要： A fluorine-containing copolymer, containing: chlorotrifluoroethylene monomer units (A); and monomer units (B), which are obtained by polymerizing a monomer selected from the group consisting of (i) a monomer having a formula: CH2═CHCOON(R0)2, wherein each R0 is independently a hydrogen or an alkyl group; (ii) N-vinylcaprolactam; (iii) a monomer having a formula: CH2═CR1CH2OCH2CR2═CH2, wherein R1 and R2 are each independently a hydrogen, a fluorine, or a methyl group; (iv) a monomer having a formula: CH2═CHCH2CH(CH3)—R3, wherein R3 is a linear alkyl group comprising 1 to 7 carbons; and (v) a monomer of methyl 2-fluoroacrylate, wherein a ratio, (A)/((A)+(B)), is from 3 to 99 mol %, a fluorine content of the copolymer is from 15 to 75 mol %, and a molecular weight of the copolymer is from 1,000 to 1,000,000.

    摘要翻译： 含有三氟氯乙烯单体单元（A）的含氟共聚物; 和单体单元（B），其通过聚合选自（i）具有式：CH 2 = CHCOON（R 0）2的单体的单体而获得的单体单元（B），其中每个R 10独立地为氢或烷基; （ii）N-乙烯基己内酰胺; （iii）具有式：CH 2 = CR 1 CH 2 OCH 2 CR 2 = CH 2的单体，其中R 1和R 2各自独立地为氢，氟或甲基; （iv）具有式：CH 2 = CHCH 2 CH（CH 3）-R 3的单体，其中R 3是包含1至7个碳的直链烷基; 和（v）2-氟丙烯酸甲酯的单体，其中（A）/（（A）+（B））的比例为3〜99摩尔％，共聚物的氟含量为15〜75摩尔 ％，共聚物的分子量为1,000〜1,000,000。

    2-arylquinolines and process for producing the same
    5.
    发明授权
    2-arylquinolines and process for producing the same 失效
    2-芳基喹啉及其制备方法

    公开(公告)号：US5856337A

    公开(公告)日：1999-01-05

    申请号：US788013

    申请日：1997-01-24

    申请人： Takashi Okazoe ,  Yoshitomi Morizawa

    发明人： Takashi Okazoe ,  Yoshitomi Morizawa

    IPC分类号： C07D215/12 ,  C07D215/18 ,  C07D215/20 ,  C07D471/04 ,  A61K31/47 ,  A61K31/475

    CPC分类号： C07D471/04 ,  C07D215/18 ,  Y02P20/55

    摘要： 2-Arylquinolines represented by formula (1): ##STR1## wherein R.sup.1, R.sup.3 to R.sup.9 each represents hydrogen, halogen, lower alkyl, cyclic lower alkyl, aryl, aralkyl, alkoxy or --C.sub.m F.sub.2m+1 ; R.sup.2 represents hydrogen, halogen, lower alkyl, cyclic lower alkyl, aryl, aralkyl, alkoxy, --C.sub.n F.sub.2n+1 or --CH.sub.2 Q, in which Q represents a monovalent organic group obtained by eliminating from an organic compound having --NH-- the hydrogen atom bonded to the nitrogen, or halogen; X represents halogen or hydrogen; Y represents nitro or amino which may be protected with a protecting group; and m and n each represents an integer of from 1 to 6; and processes for producing the 2-arylquinolines.

    摘要翻译： 由式（1）表示的2-芳基喹啉：其中R 1，R 3至R 9各自表示氢，卤素，低级烷基，环状低级烷基，芳基，芳烷基，烷氧基或-C m F 2 m + 1; R2表示氢，卤素，低级烷基，环状低级烷基，芳基，芳烷基，烷氧基，-CnF2n + 1或-CH2Q，其中Q表示通过从具有-NH-的有机化合物中除去氢原子键合获得的一价有机基团 氮或卤素; X表示卤素或氢; Y表示可被保护基保护的硝基或氨基; m和n各自表示1〜6的整数， 以及2-芳基喹啉的制造方法。

    Isoindazole compound
    6.
    发明授权
    Isoindazole compound 失效
    异吲唑化合物

    公开(公告)号：US5387684A

    公开(公告)日：1995-02-07

    申请号：US142447

    申请日：1994-01-24

    申请人： Yoshihisa Inoue ,  Hajime Ebisu ,  Norifumi Nakamura ,  Yoshitomi Morizawa ,  Takashi Okazoe ,  Arata Yasuda

    发明人： Yoshihisa Inoue ,  Hajime Ebisu ,  Norifumi Nakamura ,  Yoshitomi Morizawa ,  Takashi Okazoe ,  Arata Yasuda

    IPC分类号： C07D403/06 ,  C07D471/04 ,  C07D473/00 ,  C07D473/40 ,  C07D471/02

    CPC分类号： C07D473/00 ,  C07D403/06 ,  C07D471/04

    摘要： An isoindazole compound of the formula (1) or a salt thereof; a method for the production thereof; and pharmaceutical use of the compound and a salt thereof, particularly as an angiotensin II antagonist and as an agent for the prophylaxis and treatment of circulatory diseases (particularly hypertension and heart failure); ##STR1## wherein Q is a heterocyclic derivative of the formula (2) or (3) ##STR2## wherein other symbols of the above formulas are as defined in the Specification. The compound and its salt show superior angiotensin II antagonism and are low toxic. Accordingly, they are useful as angiotensin II antagonists for the treatment or prophylaxis of angiotensin II-mediated diseases such as circulatory diseases of hypertension (e.g. essential hypertension, renal hypertension) and heart failure.

    摘要翻译： 式（1）的异吲唑化合物或其盐; 一种生产它的方法; 以及化合物及其盐，特别是作为血管紧张素II拮抗剂和预防和治疗循环系统疾病（特别是高血压和心力衰竭）的药物的药物用途; （1）其中Q是式（2）或（3）的杂环衍生物。其中上述式的其它符号如本说明书中所定义。 该化合物及其盐显示出优异的血管紧张素II拮抗作用，毒性低。 因此，它们可用作血管紧张素II拮抗剂，用于治疗或预防血管紧张素II介导的疾病，例如高血压的循环系统疾病（例如原发性高血压，肾性高血压）和心力衰竭。

    FLUOROCOPOLYMER COMPOSITION AND ITS PRODUCTION PROCESS
    7.
    发明申请
    FLUOROCOPOLYMER COMPOSITION AND ITS PRODUCTION PROCESS 有权
    氟聚合物组合物及其生产工艺

    公开(公告)号：US20110172336A1

    公开(公告)日：2011-07-14

    申请号：US13070572

    申请日：2011-03-24

    申请人： Takashi Nakano ,  Tomoyuki Fujita ,  Yoshitomi Morizawa

    发明人： Takashi Nakano ,  Tomoyuki Fujita ,  Yoshitomi Morizawa

    IPC分类号： C08L27/18 ,  C08K5/03 ,  C08K5/315 ,  C08K5/32 ,  C08K5/101 ,  C08K5/07 ,  C08K5/136 ,  C08K5/06 ,  C08K5/3432 ,  C08K5/109 ,  C08K5/05

    CPC分类号： C08F214/18 ,  C08F214/26 ,  C08F214/265 ,  C08J3/093 ,  C08J5/18 ,  C08J2327/18 ,  C08K5/0008 ,  C09D127/12 ,  C09D127/18

    摘要： To provide a composition comprising a fluorocopolymer such as an ethylene/tetrafluoroethylene copolymer which can be produced at a relatively low temperature, and its production process.A fluorocopolymer composition which comprises a fluorocopolymer such as an ethylene/tetrafluoroethylene copolymer and a fluorinated aromatic compound having a melting point of at most 230° C. and having a fluorine content in the compound of from 5 to 75 mass %, and is in a solution state at a temperature of at most the melting point of the fluorocopolymer, and a process for producing the fluorocopolymer composition, which comprises a step of dissolving the fluorocopolymer in a solvent containing the fluorinated aromatic compound at a temperature of at most the melting point of the fluorocopolymer.

    摘要翻译： 提供包含可在较低温度下生产的含氟共聚物如乙烯/四氟乙烯共聚物及其制备方法的组合物。 一种含氟共聚物组合物，其包含含氟共聚物如乙烯/四氟乙烯共聚物和熔点至多为230℃的氟化芳族化合物，化合物中的氟含量为5〜75质量％，为 在含氟共聚物的熔点以上的温度下的溶液状态，以及含氟共聚物组合物的制造方法，其特征在于，含有含氟共聚物在含氟化芳香族化合物的溶剂中的溶解温度为 含氟共聚物。

    Lecithinized superoxide dismutase composition and a process for its production
    8.
    发明授权
    Lecithinized superoxide dismutase composition and a process for its production 有权
    卵磷脂化超氧化物歧化酶组成及其生产工艺

    公开(公告)号：US07700336B2

    公开(公告)日：2010-04-20

    申请号：US11733989

    申请日：2007-04-11

    申请人： Hideo Nomoto ,  Toshiaki Nakayama ,  Maki Murahashi ,  Yoshitomi Morizawa

    发明人： Hideo Nomoto ,  Toshiaki Nakayama ,  Maki Murahashi ,  Yoshitomi Morizawa

    IPC分类号： C12N9/02

    CPC分类号： A61K38/446 ,  C12N9/0089 ,  C12Y115/01001

    摘要： To provide a lecithinized superoxide dismutase (PC-SOD) composition useful as a drug material and a process for its production. The PC-SOD composition contains a PC-SOD obtained by substituting at least amino group in a specific SOD with a lecithin moiety represented by the following formula (I), wherein the PC-SOD contains a PC-SOD (A) having an m number of amino groups substituted with the lecithin moieties (wherein m is an integer of from 1 to 4 and averages from 1.5 to 2.4 as a main component and the PC-SOD (A) consists of a PC-SOD (a1) wherein m=1, a PC-SOD (a2) wherein m=2, a PC-SOD (a3) wherein m=3 and a PC-SOD (a4) wherein m=4.

    摘要翻译： 提供可用作药物材料的卵磷脂化超氧化物歧化酶（PC-SOD）组合物及其制备方法。 PC-SOD组合物含有通过用下述式（I）表示的卵磷脂部分取代特定SOD中的至少氨基而得到的PC-SOD，其中，PC-SOD含有具有m 用卵磷脂部分取代的氨基数（其中m为1〜4的整数，平均为1.5〜2.4为主成分，PC-SOD（A）为PC-SOD（a1），m = 1，其中m = 2的PC-SOD（a2），其中m = 3的PC-SOD（a3）和m = 4的PC-SOD（a4）。

    FLUOROCOPOLYMER COMPOSITION AND ITS PRODUCTION PROCESS
    9.
    发明申请
    FLUOROCOPOLYMER COMPOSITION AND ITS PRODUCTION PROCESS 审中-公开
    氟聚合物组合物及其生产工艺

    公开(公告)号：US20120108723A1

    公开(公告)日：2012-05-03

    申请号：US13342542

    申请日：2012-01-03

    申请人： Takashi NAKANO ,  Tomoyuki Fujita ,  Hiroshi Yamamoto ,  Yoshitomi Morizawa

    发明人： Takashi NAKANO ,  Tomoyuki Fujita ,  Hiroshi Yamamoto ,  Yoshitomi Morizawa

    IPC分类号： C08L27/18 ,  C08K5/101 ,  C08K5/109 ,  C08K5/07

    CPC分类号： C08J3/2053 ,  C08F214/265 ,  C08J3/095 ,  C08J2323/08 ,  C08J2327/18 ,  C08K5/07 ,  C09D127/18 ,  C08L27/18

    摘要： To provide a composition comprising a fluorocopolymer such as an ETFE which can be produced at a relatively low temperature, and its production process.A fluorocopolymer composition which comprises a fluorocopolymer such as an ETFE and a C6-10 aliphatic compound having one carbonyl group, and which is in a solution state being at a temperature of at most the melting point of the fluorocopolymer, and a process for producing the fluorocopolymer composition, which comprises a step of dissolving the fluorocopolymer in the aliphatic compound having one carbonyl group at a temperature of at most the melting point of the fluorocopolymer.

    摘要翻译： 提供包含可在较低温度下生产的含氟共聚物如ETFE的组合物及其制备方法。 含氟共聚物如ETFE的含氟共聚物组合物和具有一个羰基的C6-10脂肪族化合物，其处于溶解状态至多为含氟共聚物的熔点的温度，以及制备 含氟共聚物组合物，其包括在至少含氟共聚物的熔点的温度下将含氟共聚物溶解在具有一个羰基的脂族化合物中的步骤。

    PROCESS FOR PRODUCING ETHYLENE/TETRAFLUOROETHYLENE COPOLYMER POROUS MATERIAL, AND ETHYLENE/TETRAFLUOROETHYLENE COPOLYMER POROUS MATERIAL
    10.
    发明申请
    PROCESS FOR PRODUCING ETHYLENE/TETRAFLUOROETHYLENE COPOLYMER POROUS MATERIAL, AND ETHYLENE/TETRAFLUOROETHYLENE COPOLYMER POROUS MATERIAL 审中-公开
    乙烯/四氟乙烯共聚物多孔材料的生产方法和乙烯/四氟乙烯共聚物多孔材料

    公开(公告)号：US20110178193A1

    公开(公告)日：2011-07-21

    申请号：US13071720

    申请日：2011-03-25

    申请人： Ken IRUYA ,  Takashi Nakano ,  Tomoyuki Fujita ,  Yoshitomi Morizawa

    发明人： Ken IRUYA ,  Takashi Nakano ,  Tomoyuki Fujita ,  Yoshitomi Morizawa

    IPC分类号： C08J9/00 ,  C08F214/26

    CPC分类号： C08J9/28 ,  B01D67/0011 ,  B01D67/002 ,  B01D69/087 ,  B01D71/26 ,  B01D71/32 ,  B01D71/36 ,  B01D71/76 ,  B01D2323/08 ,  B01D2323/22 ,  B01D2325/22 ,  B01D2325/30 ,  C08J2201/052 ,  C08J2201/0544 ,  C08J2323/08 ,  C08J2327/18 ,  C08L23/0892 ,  C08L23/28

    摘要： To provide a method for easily producing an ethylene/tetrafluoroethylene copolymer porous material having excellent chemical resistance and filtration performance and has a high heat resistance, within a wide range of the porosity, and an ethylene/tetrafluoroethylene copolymer porous material obtained by such a process.A process for producing an ethylene/tetrafluoroethylene copolymer porous material which comprises a step of dissolving an ethylene/tetrafluoroethylene copolymer having repeating units based on ethylene and repeating units based on tetrafluoroethylene at a temperature of at most 300° C. in a solvent which can dissolve the ethylene/tetrafluoroethylene copolymer at a temperature of at most 300° C., to achieve a predetermined concentration to obtain a solution, a step of forming the solution to obtain a formed product, and a step of cooling the formed product to a temperature of at most the phase separation temperature of the solution to solidify the ethylene/tetrafluoroethylene copolymer.

    摘要翻译： 为了提供容易制造具有优异的耐化学性和过滤性能并具有高孔隙率的高耐热性的乙烯/四氟乙烯共聚物多孔材料的方法，以及通过这种方法获得的乙烯/四氟乙烯共聚物多孔材料。 一种乙烯/四氟乙烯共聚物多孔材料的制造方法，其特征在于，在可溶解的溶剂中，溶解乙烯/四氟乙烯共聚物，该乙烯/四氟乙烯共聚物具有基于乙烯的重复单元和基于四氟乙烯的重复单元，在最多300℃的温度下， 乙烯/四氟乙烯共聚物，在至多300℃的温度下，达到预定浓度以获得溶液，形成溶液以获得成形产物的步骤，以及将形成的产物冷却至 最多使溶液的相分离温度固化乙烯/四氟乙烯共聚物。