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公开(公告)号：US11420922B2
公开(公告)日：2022-08-23
申请号：US15735195
申请日：2016-06-10
IPC分类号： A61K31/675 , A61K31/122 , A61K31/7072 , A61K31/522 , A61K31/708 , A61K31/513 , A61K45/06 , A61K9/00 , A61P31/22 , C07C49/733 , C07C69/757 , C07C49/717 , A61K38/21
摘要： The present disclosure relates to inhibitors of herpesvirus nucleic acid metabolism and inhibitors of Hepatitis B virus. Also provided are methods of treatment using these agents.
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公开(公告)号：US09616119B2
公开(公告)日：2017-04-11
申请号：US14667512
申请日：2015-03-24
IPC分类号： A61K39/245 , A61K39/12 , C07K14/005 , C12N7/00 , A61K39/00
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/5254 , A61K2039/545 , C07K14/005 , C12N7/00 , C12N2710/16621 , C12N2710/16622 , C12N2710/16634 , C12N2710/16652 , C12N2710/16662 , C12N2710/16671 , A61K35/763 , A61K2039/53 , A61K35/76 , C12N2710/16632 , C12N2710/16643 , C07K14/035
摘要： A mutant HSV-1 (referred to herein as KOS-NA) was generated. KOS-NA contains novel mutations in the UL39 gene, which encodes for a protein that is a large subunit of ribonucleotide reductase (i.e., ICP6). These UL39 mutations were found to alter two amino acids in ICP6 (R950H and L393P) and are responsible for attenuation of KOS-NA in vivo, and resulted in diminished ICP6 protein levels. These novel UL39 mutations regulate the expression and/or stability of ICP6 and severely impact HSV-1 pathogenesis. Mutant HSV viruses containing these mutations appear to protect against HSV infection and can serve as therapeutic vaccines to help combat preexisting HSV infection in infected individuals.
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公开(公告)号：US20160000903A1
公开(公告)日：2016-01-07
申请号：US14667512
申请日：2015-03-24
IPC分类号： A61K39/245 , C12N7/00
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/5254 , A61K2039/545 , C07K14/005 , C12N7/00 , C12N2710/16621 , C12N2710/16622 , C12N2710/16634 , C12N2710/16652 , C12N2710/16662 , C12N2710/16671 , A61K35/763 , A61K2039/53 , A61K35/76 , C12N2710/16632 , C12N2710/16643 , C07K14/035
摘要： A mutant HSV-1 (referred to herein as KOS-NA) was generated. KOS-NA contains novel mutations in the UL39 gene, which encodes for a protein that is a large subunit of ribonucleotide reductase (i.e., ICP6). These UL39 mutations were found to alter two amino acids in ICP6 (R950H and L393P) and are responsible for attenuation of KOS-NA in vivo, and resulted in diminished ICP6 protein levels. These novel UL39 mutations regulate the expression and/or stability of ICP6 and severely impact HSV-1 pathogenesis. Mutant HSV viruses containing these mutations appear to protect against HSV infection and can serve as therapeutic vaccines to help combat preexisting HSV infection in infected individuals.
摘要翻译： 产生突变体HSV-1（本文称为KOS-NA）。 KOS-NA包含UL39基因中的新突变，其编码作为核糖核苷酸还原酶的大亚基（即，ICP6）的蛋白质。 发现这些UL39突变可以改变ICP6（R950H和L393P）中的两个氨基酸，并且负责体内KOS-NA的减弱，导致ICP6蛋白水平降低。 这些新的UL39突变调节ICP6的表达和/或稳定性，并严重影响HSV-1发病机制。 含有这些突变的突变型HSV病毒似乎可以防止HSV感染，可以作为治疗性疫苗，以帮助预防感染个体的预先存在的HSV感染。
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4.发明授权公开(公告)号：US11191754B2
公开(公告)日：2021-12-07
申请号：US16533204
申请日：2019-08-06
IPC分类号： A61K31/4412 , C07D213/89 , A61P31/12 , C12N9/22 , A61P31/22 , A61K9/00 , A61K31/122 , A61K31/4375 , A61K31/513 , A61K31/52 , A61K31/522 , A61K31/662 , A61K31/675 , A61K31/7072 , A61K31/7076 , A61K38/21 , C07C50/28 , C07D471/04
摘要： The present disclosure relates to identification of inhibitors of hepatitis and herpesvirus replication including compounds of the formula: wherein the variables are as defined herein. Also provided are methods of treatment using agents so identified.
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公开(公告)号：US10463664B2
公开(公告)日：2019-11-05
申请号：US15038515
申请日：2014-11-25
IPC分类号： A61K31/122 , A61K31/506 , A61K45/06 , A61K31/4418 , A61K31/352 , A61K31/4196 , A61K31/4245 , A61K31/4375 , A61K31/4433 , A61K31/4704 , C07D413/12 , C07D471/04 , A61K31/047 , A61K31/045
摘要： The present invention involves identification of inhibitors of herpesvirus nucleic acid metabolism. Also provided are methods of treatment using agents identified.
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