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1.发明授权Oligonucleotides useful for detecting and analyzing nucleic acids of interest 有权可用于检测和分析感兴趣的核酸的寡核苷酸公开(公告)号：US09464106B2
公开(公告)日：2016-10-11
申请号：US13295615
申请日：2011-11-14
申请人： Sakari Kauppinen , Carsten Alsbo , Peter S. Nielsen , Daniel C. Jeffares , Tobias Mourier , Søren Mørk , Peter Arctander , Niels Tommerup , Niels Tolstrup , Henrik Vissing , Søren Morgenthaler Echwald
发明人： Sakari Kauppinen , Carsten Alsbo , Peter S. Nielsen , Daniel C. Jeffares , Tobias Mourier , Søren Mørk , Peter Arctander , Niels Tommerup , Niels Tolstrup , Henrik Vissing , Søren Morgenthaler Echwald
摘要： The invention features improved nucleic acids and methods for expression profiling of mRNAs, identifying and profiling of particular mRNA splice variants, and detecting mutations, deletions, or duplications of particular exons or other splice variants, e.g., alterations associated with a disease such as cancer, in a nucleic acid sample, e.g., a biological sample or a patient sample.
摘要翻译： 本发明的特征在于改进的核酸和用于mRNA表达谱的方法，特异性mRNA剪接变体的鉴定和分析，以及检测特定外显子或其他剪接变体的突变，缺失或重复，例如与疾病如癌症相关的改变， 在核酸样品中，例如生物样品或患者样品。
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2.发明申请OLIGONUCLEOTIDES USEFUL FOR DETECTING AND ANALYZING NUCLEIC ACIDS OF INTEREST 有权用于检测和分析有益的核酸的有效的寡核苷酸公开(公告)号：US20120157333A1
公开(公告)日：2012-06-21
申请号：US13295615
申请日：2011-11-14
申请人： Sakari Kauppinen , Carsten Alsbo , Peter S. Nielsen , Daniel C. Jeffares , Tobias Mourier , Søren Mørk , Peter Arctander , Niels Tommerup , Niels Tolstrup , Henrik Vissing , Søren Morgenthaler Echwald
发明人： Sakari Kauppinen , Carsten Alsbo , Peter S. Nielsen , Daniel C. Jeffares , Tobias Mourier , Søren Mørk , Peter Arctander , Niels Tommerup , Niels Tolstrup , Henrik Vissing , Søren Morgenthaler Echwald
摘要： The invention features improved nucleic acids and methods for expression profiling of mRNAs, identifying and profiling of particular mRNA splice variants, and detecting mutations, deletions, or duplications of particular exons or other splice variants, e.g., alterations associated with a disease such as cancer, in a nucleic acid sample, e.g., a biological sample or a patient sample.
摘要翻译： 本发明的特征在于改进的核酸和用于mRNA表达谱的方法，特异性mRNA剪接变体的鉴定和分析，以及检测特定外显子或其他剪接变体的突变，缺失或重复，例如与疾病如癌症相关的改变， 在核酸样品中，例如生物样品或患者样品。
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3.发明申请Oligonucleotide probes useful for detection and analysis of microrna precursors 审中-公开可用于检测和分析微棱镜前体的寡核苷酸探针公开(公告)号：US20090023221A1
公开(公告)日：2009-01-22
申请号：US11803891
申请日：2007-05-16
申请人： Gregor Obernosterer , Nina Stahlberg , Soren Moller , Soren M. Echwald , Peter Mouritzen , Peter S. Nielsen , Mikkel Norholm , Kim Bundvig Barken
发明人： Gregor Obernosterer , Nina Stahlberg , Soren Moller , Soren M. Echwald , Peter Mouritzen , Peter S. Nielsen , Mikkel Norholm , Kim Bundvig Barken
CPC分类号： C12Q1/6876 , C12Q1/6816 , C12Q2600/158 , C12Q2600/166 , C12Q2600/178 , Y10T436/143333 , C12Q2525/101 , C12Q2525/185 , C12Q2525/207
摘要： The invention relates to ribonucleic acids and oligonucleotide probes useful for detection and analysis of microRNA precursors and their targets. The invention furthermore relates to oligonucleotide probes for detection and analysis of other non-coding RNAs, mRNAs, mRNA splice variants, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease, such as cancer.
摘要翻译： 本发明涉及可用于检测和分析微小RNA前体及其靶标的核糖核酸和寡核苷酸探针。 本发明还涉及用于检测和分析其他非编码RNA，mRNA，mRNA剪接变体，单个转录物的等位变体，突变，缺失或转录物中特定外显子重复的寡核苷酸探针，例如与人类疾病相关的改变， 如癌症。
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