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1.发明申请Oligonucleotide probes useful for detection and analysis of microrna precursors 审中-公开可用于检测和分析微棱镜前体的寡核苷酸探针公开(公告)号：US20090023221A1
公开(公告)日：2009-01-22
申请号：US11803891
申请日：2007-05-16
申请人： Gregor Obernosterer , Nina Stahlberg , Soren Moller , Soren M. Echwald , Peter Mouritzen , Peter S. Nielsen , Mikkel Norholm , Kim Bundvig Barken
发明人： Gregor Obernosterer , Nina Stahlberg , Soren Moller , Soren M. Echwald , Peter Mouritzen , Peter S. Nielsen , Mikkel Norholm , Kim Bundvig Barken
CPC分类号： C12Q1/6876 , C12Q1/6816 , C12Q2600/158 , C12Q2600/166 , C12Q2600/178 , Y10T436/143333 , C12Q2525/101 , C12Q2525/185 , C12Q2525/207
摘要： The invention relates to ribonucleic acids and oligonucleotide probes useful for detection and analysis of microRNA precursors and their targets. The invention furthermore relates to oligonucleotide probes for detection and analysis of other non-coding RNAs, mRNAs, mRNA splice variants, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease, such as cancer.
摘要翻译： 本发明涉及可用于检测和分析微小RNA前体及其靶标的核糖核酸和寡核苷酸探针。 本发明还涉及用于检测和分析其他非编码RNA，mRNA，mRNA剪接变体，单个转录物的等位变体，突变，缺失或转录物中特定外显子重复的寡核苷酸探针，例如与人类疾病相关的改变， 如癌症。
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公开(公告)号：US20060014183A1
公开(公告)日：2006-01-19
申请号：US11149910
申请日：2005-06-10
申请人： Henrik Pfundheller , Michael Meldgaard , Peter Mouritzen , Peter Nielsen , Mikkel Norholm , Soren Echwald
发明人： Henrik Pfundheller , Michael Meldgaard , Peter Mouritzen , Peter Nielsen , Mikkel Norholm , Soren Echwald
CPC分类号： C12Q1/6853 , C12Q2525/107 , C12Q2525/186
摘要： The invention relates to probes which are extendable useful as PCR probes and in probe libraries. The invention further relates to prevention of replication of a primer extension product in PCR reactions.
摘要翻译： 本发明涉及可扩展用作PCR探针和探针文库的探针。 本发明还涉及在PCR反应中预防引物延伸产物的复制。
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3.发明申请公开(公告)号：US20050272075A1
公开(公告)日：2005-12-08
申请号：US11100897
申请日：2005-04-07
申请人： Nana Jacobsen , Lars Kongsbak , Sakari Kauppinen , Soren Echwald , Peter Mouritzen , Peter Nielsen , Mikkel Norholm
发明人： Nana Jacobsen , Lars Kongsbak , Sakari Kauppinen , Soren Echwald , Peter Mouritzen , Peter Nielsen , Mikkel Norholm
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q1/6809 , C12Q2533/107 , C12Q2525/207 , C12Q2525/155 , C12Q2561/101
摘要： The invention relates to ribonucleic acids, probes and methods for detection, quantification as well as monitoring the expression of mature microRNAs and small interfering RNAs (siRNAs). The invention furthermore relates to methods for monitoring the expression of other non-coding RNAs, mRNA splice variants, as well as detecting and quantifying RNA editing, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease such as cancer. The invention furthermore relates to methods for detection, quantification as well as monitoring the expression of deoxy nucleic acids.
摘要翻译： 本发明涉及核糖核酸，探针和检测，定量的方法以及监测成熟微小RNA和小干扰RNA（siRNA）的表达。 本发明还涉及用于监测其他非编码RNA，mRNA剪接变体表达的方法，以及检测和定量RNA编辑，单个转录物的等位基因变体，突变，缺失或转录本中特定外显子的重复，例如， 与人类疾病如癌症相关的改变。 本发明还涉及用于检测，定量以及监测脱氧核酸表达的方法。
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4.发明申请Probes, libraries and kits for analysis of mixtures of nucleic acids and methods for constructing the same 审中-公开用于分析核酸混合物的探针，文库和试剂盒及其构建方法公开(公告)号：US20060166238A1
公开(公告)日：2006-07-27
申请号：US11314868
申请日：2005-12-21
申请人： Niels Ramsing , Peter Mouritzen , Soren Echwald , Niels Tolstrup
发明人： Niels Ramsing , Peter Mouritzen , Soren Echwald , Niels Tolstrup
CPC分类号： C12Q1/6816 , C12Q1/6851 , G16B25/00 , G16B35/00 , G16C20/60 , C12Q2525/204 , C12Q2525/179 , C12Q2525/113 , C12Q2537/143 , C12Q2561/113
摘要： The invention relates to nucleic acid probes, nucleic acid probe libraries, and kits for detecting, classifying, or quantifying components in a complex mixture of nucleic acids, such as a transcriptome, and methods of using the same. The invention also relates to methods of identifying nucleic acid probes useful in the probe libraries and to methods of identifying a means for detection of a given nucleic acid.
摘要翻译： 本发明涉及核酸探针，核酸探针文库和用于检测，分类或定量核酸复合物如转录组的组分的试剂盒及其使用方法。 本发明还涉及鉴定在探针文库中有用的核酸探针的方法以及鉴定用于检测给定核酸的手段的方法。
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公开(公告)号：US08383344B2
公开(公告)日：2013-02-26
申请号：US12476193
申请日：2009-06-01
申请人： Nana Jacobsen , Lars Kongsbak , Sakari Kauppinen , Søren Morgenthaler Echwald , Peter Mouritzen , Peter Stein Nielsen , Mikkel Nørholm
发明人： Nana Jacobsen , Lars Kongsbak , Sakari Kauppinen , Søren Morgenthaler Echwald , Peter Mouritzen , Peter Stein Nielsen , Mikkel Nørholm
CPC分类号： C12Q1/6816 , C12Q1/6809 , C12Q2533/107 , C12Q2525/207 , C12Q2525/155 , C12Q2561/101
摘要： The invention relates to ribonucleic acids, probes and methods for detection, quantification as well as monitoring the expression of mature microRNAs and small interfering RNAs (siRNAs). The invention furthermore relates to methods for monitoring the expression of other non-coding RNAs, mRNA splice variants, as well as detecting and quantifying RNA editing, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease such as cancer. The invention furthermore relates to methods for detection, quantification as well as monitoring the expression of deoxy nucleic acids.
摘要翻译： 本发明涉及核糖核酸，探针和检测，定量的方法以及监测成熟微小RNA和小干扰RNA（siRNA）的表达。 本发明还涉及用于监测其他非编码RNA，mRNA剪接变体表达的方法，以及检测和定量RNA编辑，单个转录物的等位基因变体，突变，缺失或转录本中特定外显子的重复，例如， 与人类疾病如癌症相关的改变。 本发明还涉及用于检测，定量以及监测脱氧核酸表达的方法。
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公开(公告)号：US08192937B2
公开(公告)日：2012-06-05
申请号：US11100897
申请日：2005-04-07
申请人： Nana Jacobsen , Lars Kongsbak , Sakari Kauppinen , Søren Morgenthaler Echwald , Peter Mouritzen , Peter Stein Nielsen , Mikkel Nørholm
发明人： Nana Jacobsen , Lars Kongsbak , Sakari Kauppinen , Søren Morgenthaler Echwald , Peter Mouritzen , Peter Stein Nielsen , Mikkel Nørholm
CPC分类号： C12Q1/6816 , C12Q1/6809 , C12Q2533/107 , C12Q2525/207 , C12Q2525/155 , C12Q2561/101
摘要： The invention relates to ribonucleic acids, probes and methods for detection, quantification as well as monitoring the expression of mature microRNAs and small interfering RNAs (siRNAs). The invention furthermore relates to methods for monitoring the expression of other non-coding RNAs, mRNA splice variants, as well as detecting and quantifying RNA editing, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease such as cancer. The invention furthermore relates to methods for detection, quantification as well as monitoring the expression of deoxy nucleic acids.
摘要翻译： 本发明涉及核糖核酸，探针和检测，定量的方法以及监测成熟微小RNA和小干扰RNA（siRNA）的表达。 本发明还涉及用于监测其他非编码RNA，mRNA剪接变体表达的方法，以及检测和定量RNA编辑，单个转录物的等位基因变体，突变，缺失或转录本中特定外显子的重复，例如， 与人类疾病如癌症相关的改变。 本发明还涉及用于检测，定量以及监测脱氧核酸表达的方法。
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7.发明申请公开(公告)号：US20110076675A1
公开(公告)日：2011-03-31
申请号：US12476193
申请日：2009-06-01
申请人： Nana Jacobsen , Lars Kongsbak , Sakari Kauppinen , Søren Morgenthaler Echwald , Peter Mouritzen , Peter Stein Nielsen , Mikkel Nørholm
发明人： Nana Jacobsen , Lars Kongsbak , Sakari Kauppinen , Søren Morgenthaler Echwald , Peter Mouritzen , Peter Stein Nielsen , Mikkel Nørholm
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q1/6809 , C12Q2533/107 , C12Q2525/207 , C12Q2525/155 , C12Q2561/101
摘要： The invention relates to ribonucleic acids, probes and methods for detection, quantification as well as monitoring the expression of mature microRNAs and small interfering RNAs (siRNAs). The invention furthermore relates to methods for monitoring the expression of other non-coding RNAs, mRNA splice variants, as well as detecting and quantifying RNA editing, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease such as cancer. The invention furthermore relates to methods for detection, quantification as well as monitoring the expression of deoxy nucleic acids.
摘要翻译： 本发明涉及核糖核酸，探针和检测，定量的方法以及监测成熟微小RNA和小干扰RNA（siRNA）的表达。 本发明还涉及用于监测其他非编码RNA，mRNA剪接变体表达的方法，以及检测和定量RNA编辑，单个转录物的等位基因变体，突变，缺失或转录本中特定外显子的重复，例如， 与人类疾病如癌症相关的改变。 本发明还涉及用于检测，定量以及监测脱氧核酸表达的方法。
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公开(公告)号：US08293684B2
公开(公告)日：2012-10-23
申请号：US11947724
申请日：2007-11-29
CPC分类号： C07H19/24
摘要： The present invention relates to labeling kits containing novel non-natural nucleotide monomers and to methods of making and using such compounds. The invention further relates to a method of detecting the presence of a nucleic acid, e.g., RNA, of interest in a sample, the method having the following steps: providing the sample; ligating a nucleic acid of interest with a labeling reagent according to the instant invention; providing a nucleic acid array having probes directed to the nucleic acid of interest; hybridizing the labeled nucleic acid fragments to said nucleic acid array; and determining the extent of hybridization to said probes to determine the presence of the nucleic acid of interest.
摘要翻译： 本发明涉及包含新型非天然核苷酸单体的标记试剂盒以及制备和使用这些化合物的方法。 本发明还涉及一种检测样品中感兴趣的核酸如RNA的存在的方法，该方法具有以下步骤：提供样品; 将感兴趣的核酸与根据本发明的标记试剂连接; 提供具有指向感兴趣的核酸的探针的核酸阵列; 将标记的核酸片段与所述核酸阵列杂交; 以及确定与所述探针的杂交程度，以确定感兴趣的核酸的存在。
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公开(公告)号：US20090023594A1
公开(公告)日：2009-01-22
申请号：US11947724
申请日：2007-11-29
CPC分类号： C07H19/24
摘要： The present invention relates to labelling kits containing novel non-natural nucleotide monomers and to methods of making and using such compounds. The invention further relates to a method of detecting the presence of a nucleic acid, e.g., RNA, of interest in a sample, the method having the following steps: providing the sample; ligating a nucleic acid of interest with a labelling reagent according to the instant invention; providing a nucleic acid array having probes directed to the nucleic acid of interest; hybridizing the labelled nucleic acid fragments to said nucleic acid array; and determining the extent of hybridization to said probes to determine the presence of the nucleic acid of interest.
摘要翻译： 本发明涉及包含新型非天然核苷酸单体的标记试剂盒以及制备和使用这些化合物的方法。 本发明还涉及一种检测样品中感兴趣的核酸如RNA的存在的方法，该方法具有以下步骤：提供样品; 将感兴趣的核酸与根据本发明的标记试剂连接; 提供具有指向感兴趣的核酸的探针的核酸阵列; 将标记的核酸片段与所述核酸阵列杂交; 以及确定与所述探针的杂交程度，以确定感兴趣的核酸的存在。
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10.发明申请Probes, libraries and kits for analysis of mixtures of nucleic acids and methods for constructing the same 审中-公开用于分析核酸混合物的探针，文库和试剂盒及其构建方法公开(公告)号：US20050089889A1
公开(公告)日：2005-04-28
申请号：US10871471
申请日：2004-06-18
申请人： Niels Ramsing , Peter Mouritzen , Soren Echwald , Niels Tolstrup
发明人： Niels Ramsing , Peter Mouritzen , Soren Echwald , Niels Tolstrup
CPC分类号： C12Q1/6876 , C12N15/1065 , C12Q1/6816 , C12Q2600/158 , G16B25/00 , C12Q2531/113 , C12Q2527/101 , C12Q2525/179
摘要： The invention relates to nucleic acid probes, nucleic acid probe libraries, and kits for detecting, classifying, or quantitating components in a complex mixture of nucleic acids, such as a transcriptome, and methods of using the same. The invention also relates to methods of identifying nucleic acid probes useful in the probe libraries and to methods of identifying a means for detection of a given nucleic acid.
摘要翻译： 本发明涉及核酸探针，核酸探针文库和用于检测，分类或定量核酸复合物如转录组的组分的试剂盒及其使用方法。 本发明还涉及鉴定在探针文库中有用的核酸探针的方法以及鉴定用于检测给定核酸的手段的方法。
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