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公开(公告)号:US11420934B2
公开(公告)日:2022-08-23
申请号:US16715711
申请日:2019-12-16
发明人: Ronald M. Evans , Michael Downes , Thomas J. Baiga , Joseph P. Noel , Emi Kanakubo Embler , Weiwei Fan , John F. W. Keana , Mark G. Bock , Authur F. Kluge , Mike A. Patane
IPC分类号: C07C233/87 , A61K31/381 , A61K31/5377 , A61K31/44 , A61K31/4025 , A61K31/422 , A61K31/341 , A61K31/427 , A61K31/164 , A61K31/4178 , C07C255/57 , C07C317/44 , C07C233/73 , C07C235/42 , C07C235/48 , C07C235/84 , C07C237/22 , C07C237/32 , C07D309/06 , C07D405/04 , C07D405/10 , C07D407/12 , C07D413/04 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/10 , C07D417/12 , C07D207/04 , C07D271/12 , C07D209/34 , C07D295/13 , C07D305/06 , C07D307/83 , C07D231/12 , C07D333/24 , C07D405/12 , C07D213/56 , C07D307/54 , C07C237/48 , C07C259/06
摘要: Provided herein are compounds and compositions useful in increasing PPARδ activity. The compounds and compositions provided herein are useful for the treatment of PPARδ related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).
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公开(公告)号:US09938234B2
公开(公告)日:2018-04-10
申请号:US14874008
申请日:2015-10-02
发明人: Ronald M. Evans , Michael Downes , Thomas J. Baiga , Joseph P. Noel , Emi Kanakubo Embler , Weiwei Fan , John F. W. Keana , Mark G. Bock , Arthur F. Kluge , Mike A. Patane
IPC分类号: C07C233/87 , C07D231/12 , C07D233/24 , C07D405/12 , C07D213/56 , C07D307/54 , C07C255/57 , C07C317/44 , C07C233/73 , C07C235/42 , C07C235/48 , C07C235/84 , C07C237/22 , C07D309/06 , C07D405/04 , C07D405/10 , C07D407/12 , A61K31/381 , A61K31/5377 , A61K31/44 , A61K31/4025 , A61K31/422 , A61K31/341 , A61K31/427 , A61K31/164 , A61K31/4178 , C07D333/24 , C07C237/32 , C07D413/04 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/10 , C07D417/12 , C07D207/04 , C07D271/12 , C07D209/34 , C07D295/13 , C07D305/06 , C07D307/83 , C07C237/48 , C07C259/06
CPC分类号: C07C233/87 , A61K31/164 , A61K31/341 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/44 , A61K31/5377 , C07C233/73 , C07C235/42 , C07C235/48 , C07C235/84 , C07C237/22 , C07C237/32 , C07C237/48 , C07C255/57 , C07C259/06 , C07C317/44 , C07C2601/02 , C07D207/04 , C07D209/34 , C07D213/56 , C07D231/12 , C07D271/12 , C07D295/13 , C07D305/06 , C07D307/54 , C07D307/83 , C07D309/06 , C07D333/24 , C07D405/04 , C07D405/10 , C07D405/12 , C07D407/12 , C07D413/04 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/10 , C07D417/12
摘要: Provided herein are compounds and compositions useful in increasing PPARδ activity. The compounds and compositions provided herein are useful for the treatment of PPARδ related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).
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公开(公告)号:US20160023991A1
公开(公告)日:2016-01-28
申请号:US14874008
申请日:2015-10-02
发明人: Ronald M. Evans , Michael Downes , Thomas J. Baiga , Joseph P. Noel , Emi Kanakubo Embler , Weiwei Fan , John F.W. Keana , Mark G. Bock , Arthur F. Kluge , Mike A. Patane
IPC分类号: C07C233/87 , C07C259/06 , C07D213/56 , C07D405/04 , C07D307/54 , C07D333/24 , C07D295/13 , C07C237/48 , C07D231/12
CPC分类号: C07C233/87 , A61K31/164 , A61K31/341 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/44 , A61K31/5377 , C07C233/73 , C07C235/42 , C07C235/48 , C07C235/84 , C07C237/22 , C07C237/32 , C07C237/48 , C07C255/57 , C07C259/06 , C07C317/44 , C07C2601/02 , C07D207/04 , C07D209/34 , C07D213/56 , C07D231/12 , C07D271/12 , C07D295/13 , C07D305/06 , C07D307/54 , C07D307/83 , C07D309/06 , C07D333/24 , C07D405/04 , C07D405/10 , C07D405/12 , C07D407/12 , C07D413/04 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/10 , C07D417/12
摘要: Provided herein are compounds and compositions useful in increasing PPARδ activity. The compounds and compositions provided herein are useful for the treatment of PPARδ related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).
摘要翻译: 本文提供了可用于增加PPARδ活性的化合物和组合物。 本文提供的化合物和组合物可用于治疗PPARδ相关疾病(例如肌肉疾病,血管疾病,脱髓鞘疾病和代谢疾病)。
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公开(公告)号:US10550071B2
公开(公告)日:2020-02-04
申请号:US15897796
申请日:2018-02-15
发明人: Ronald M. Evans , Michael Downes , Thomas J. Baiga , Joseph P. Noel , Emi Kanakubo Embler , Weiwei Fan , John F. W. Keana , Mark G. Bock , Arthur F. Kluge , Mike A. Patane
IPC分类号: A61K31/381 , A61K31/5377 , A61K31/44 , A61K31/4025 , A61K31/422 , A61K31/341 , A61K31/427 , A61K31/164 , A61K31/4178 , C07C233/87 , C07C255/57 , C07C317/44 , C07C233/73 , C07C235/42 , C07C235/48 , C07C235/84 , C07C237/22 , C07C237/32 , C07D309/06 , C07D405/04 , C07D405/10 , C07D407/12 , C07D413/04 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/10 , C07D417/12 , C07D207/04 , C07D271/12 , C07D209/34 , C07D295/13 , C07D305/06 , C07D307/83 , C07D231/12 , C07D333/24 , C07D405/12 , C07D213/56 , C07D307/54 , C07C237/48 , C07C259/06
摘要: Provided herein are compounds and compositions useful in increasing PPARδ activity. The compounds and compositions provided herein are useful for the treatment of PPARδ related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).
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公开(公告)号:US20180170857A1
公开(公告)日:2018-06-21
申请号:US15897796
申请日:2018-02-15
发明人: Ronald M. Evans , Michael Downes , Thomas J. Baiga , Joseph P. Noel , Emi Kanakubo Embler , Weiwei Fan , John F.W. Keana , Mark G. Bock , Authur F. Kluge , Mike A. Patane
IPC分类号: C07C233/87 , A61K31/4178 , C07C255/57 , A61K31/427 , A61K31/341 , A61K31/422 , A61K31/44 , A61K31/5377 , A61K31/381 , A61K31/4025 , C07D307/83 , C07D305/06 , C07D295/13 , C07D209/34 , C07D271/12 , C07D207/04 , C07D417/12 , C07D417/10 , C07D417/04 , C07D413/12 , C07D413/10 , C07D413/04 , C07D405/10 , C07D405/04 , C07D309/06 , C07D407/12 , C07C259/06 , C07C237/48 , C07D307/54 , C07D213/56 , C07D405/12 , C07D333/24 , C07D231/12 , C07C237/32 , C07C237/22 , C07C235/84 , C07C235/48 , C07C235/42 , C07C233/73 , C07C317/44 , A61K31/164
摘要: Provided herein are compounds and compositions useful in increasing PPARδ activity. The compounds and compositions provided herein are useful for the treatment of PPARδ related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).
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