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公开(公告)号：US4857330A
公开(公告)日：1989-08-15
申请号：US176561
申请日：1988-04-01
CPC分类号： A61K9/0004 , A61K31/44
摘要： An osmotic dosage form is disclosed for delivering chlorpheniramine.
摘要翻译： 公开了用于递送氯苯那敏的渗透剂型。
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公开(公告)号：US4863456A
公开(公告)日：1989-09-05
申请号：US153306
申请日：1988-02-08
IPC分类号： A61K9/00
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising a wall surrounding a compartment housing a first layer comprising a drug formulation, a middle layer comprising a hydrophobic composition, and a third layer comprising a hydrophilic composition.
摘要翻译： 公开了一种剂型，其包括围绕容纳包含药物制剂的第一层的隔室，包含疏水性组合物的中间层和包含亲水性组合物的第三层。
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公开(公告)号：US4960416A
公开(公告)日：1990-10-02
申请号：US377647
申请日：1989-07-10
IPC分类号： A61K9/00
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising a wall surrounding a compartment housing a first layer comprising a drug formulation, a middle layer comprising a hydrophobic composition, and a third layer comprising a hydrophilic composition.
摘要翻译： 公开了一种剂型，其包括围绕容纳包含药物制剂的第一层的隔室，包含疏水性组合物的中间层和包含亲水性组合物的第三层。
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4.发明授权Conversion of liquid filled gelatin capsules into controlled release systems by multiple coatings 失效液体填充的明胶胶囊通过多个涂层转化为控制释放系统公开(公告)号：US06929803B2
公开(公告)日：2005-08-16
申请号：US10117359
申请日：2002-04-04
申请人： Patrick S. L. Wong , Liang C. Dong , Jiansheng Wan
发明人： Patrick S. L. Wong , Liang C. Dong , Jiansheng Wan
CPC分类号： A61K9/0004
摘要： A dosage form comprising a gelatin capsule formed with a composite wall and containing a liquid, active agent formulation where the wall comprises a barrier layer formed over the external surface of the gelatin capsule, an expandable layer formed over the barrier layer and a semipermeable layer formed over the expandable layer is described. The dosage forms and methods provide for the conversion of standard gelatin, liquid formulation capsules into controlled, release dosage forms that permit the controlled release of the active agent into the environment of use over time.
摘要翻译： 一种剂型，其包含形成有复合壁并且含有液体活性剂制剂的明胶胶囊，其中所述壁包含形成在所述明胶胶囊的外表面上的阻挡层，形成在阻挡层上的可膨胀层和形成的半透膜 描述在可膨胀层之上。 剂型和方法提供将标准明胶，液体制剂胶囊转化成受控释放剂型，其允许活性剂随时间的控制释放到使用环境中。
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公开(公告)号：US06572582B1
公开(公告)日：2003-06-03
申请号：US09447655
申请日：1999-11-23
IPC分类号： A61M3700
CPC分类号： A61J1/2093 , A61J7/0038
摘要： The present invention is directed to a mixing system for an active agent delivery device. The device comprises an elongate tubular member having first and second ends and a mixing system. The mixing system enables the entire dose of active agent to be entrained in a liquid. In use, liquid is drawn into the first end of the device, the mixing system mixes the liquid and active agent within the device and the active agent entrained in the liquid is drawn out of the second end of the member and into the patient's mouth.
摘要翻译： 本发明涉及一种用于活性剂输送装置的混合系统。 该装置包括具有第一端和第二端的细长管状构件和混合系统。 混合系统使整个剂量的活性剂被夹带在液体中。 在使用中，液体被吸入装置的第一端，混合系统将液体和活性剂混合在装置内，并且夹带在液体中的活性剂从该构件的第二端引出并进入患者的口中。
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公开(公告)号：US06440457B1
公开(公告)日：2002-08-27
申请号：US08068480
申请日：1993-05-27
IPC分类号： A61K922
CPC分类号： A61K31/135 , A61K9/0004 , Y10S514/96 , Y10S514/964
摘要： The invention pertains to a dosage form 10 and to administering an antidepressant medicament 16 for an extended period of time in a rate-known dose.
摘要翻译： 本发明涉及一种剂型10，并以剂量已知的剂量给予抗抑郁药物16延长一段时间。
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公开(公告)号：US06174547B1
公开(公告)日：2001-01-16
申请号：US09353702
申请日：1999-07-14
IPC分类号： A61K948
CPC分类号： A61K9/4858 , A61K9/0004 , A61K9/1075 , A61K9/4866
摘要： A dosage form is disclosed comprising a drug formulation that self-emulsifies in said dosage form.
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公开(公告)号：US6120803A
公开(公告)日：2000-09-19
申请号：US131923
申请日：1998-08-10
申请人： Patrick S. L. Wong , Liang-Chang Dong , David E. Edgren , Felix Theeuwes , Phyllis I. Gardner , Francisco Jao , Jason J. Wan
发明人： Patrick S. L. Wong , Liang-Chang Dong , David E. Edgren , Felix Theeuwes , Phyllis I. Gardner , Francisco Jao , Jason J. Wan
IPC分类号： A61K47/22 , A61K9/00 , A61K9/20 , A61K9/22 , A61K9/26 , A61K31/341 , A61K31/522 , A61K45/00 , A61P31/12
CPC分类号： A61K9/0065 , A61K9/2072
摘要： The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a polymer matrix that swells upon contact with the fluids of the stomach. A portion of the polymer matrix is surrounded by a band of insoluble material that prevents the covered portion of the polymer matrix from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.
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公开(公告)号：US6096339A
公开(公告)日：2000-08-01
申请号：US826642
申请日：1997-04-04
CPC分类号： A61K9/0004
摘要： The invention disclosed pertains to a dosage form comprising an agent formulation comprising drug and pharmaceutical carrier of cooperating particle size and means for dispensing the agent formulation from the dosage form.
摘要翻译： 所公开的本发明涉及包含药物制剂的剂型，其包含具有协调粒径的药物和药物载体以及用于从剂型分配药剂制剂的装置。
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公开(公告)号：US5512299A
公开(公告)日：1996-04-30
申请号：US092024
申请日：1993-07-14
CPC分类号： A61K31/573 , A61K9/0004 , A61K9/006
摘要： A method of treating inflammatory disease of the mouth by locally delivering beclomethasone dipropionate and related compounds to the oral cavity of a patient over an extended period of time is disclosed. In one embodiment, beclomethasone dipropionate is delivered by an osmotic device (10), in another embodiment, it is delivered by an erosion controlled device (110) and in yet another embodiment, it is delivered by a diffusion controlled device (310).
摘要翻译： 公开了一种通过在长时间内将二丙酸倍氯米松和相关化合物局部递送到患者的口腔来治疗口腔炎症的方法。 在一个实施方案中，二丙酸倍氯米松通过渗透装置（10）递送，在另一个实施方案中，其由侵蚀受控装置（110）递送，并且在另一个实施方案中，其由扩散控制装置（310）递送。
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