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1.发明授权Mutant microorganism having improved 1,4-BDO productivity and method of preparing 1,4-BDO using the mutant microorganism 有权具有改善的1,4-BDO生产力的突变体微生物和使用突变微生物制备1,4-BDO的方法公开(公告)号：US09416379B2
公开(公告)日：2016-08-16
申请号：US13952410
申请日：2013-07-26
Applicant: Samsung Electronics Co., Ltd.
Inventor： Kyu-sang Lee , Young-min Lee , Woo-yong Lee , Hyun-min Koo , Jin-woo Kim , Young-kyoung Park , Jin-hwan Park , Hwa-young Cho , Jae-chan Park
CPC classification number: C12P7/18 , C12N9/0006 , C12N15/52 , C12N15/77 , C12Y101/01037 , C12Y101/05004 , Y02P20/52
Abstract: A recombinantly modified Corynebacterium glutamicum microorganism with an improved 1,4-butanediol (1,4-BDO) productivity relative to an unmodified Corynebacterium glutamicum microorganism, wherein activity of an enzyme catalyzing a conversion reaction between malate and oxaloacetate is inactivated or reduced relative to an unmodified Corynebacterium glutamicum microorganism, as well as a method of making and using same.
Abstract translation: 相对于未修饰的谷氨酸棒杆菌微生物，具有改进的1,4-丁二醇（1,4-BDO）生产力的重组修饰的谷氨酸棒杆菌微生物，其中催化苹果酸和草酰乙酸之间的转化反应的酶的活性相对于 未经修饰的谷氨酸棒杆菌微生物，以及其制备和使用方法。
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