公开(公告)号：US20150024447A1

公开(公告)日：2015-01-22

申请号：US14335632

申请日：2014-07-18

Applicant: Samsung Electronics Co., Ltd.

Inventor： Ji-eun KIM ,  Jin-woo Park ,  Jin-hwan Park ,  Yu-kyung Jung ,  Hwa-young Cho ,  Jae Chan Park ,  Kwang-myung Cho

IPC: C12P7/18 ,  C12N9/02

CPC classification number: C12P7/18 ,  C12N9/0008 ,  C12Y102/01057

Abstract: A mutant butyraldehyde dehydrogenase (Bld), a polynucleotide having a nucleotide encoding the mutant, a vector including the polynucleotide, a microorganism including a nucleotide encoding the mutant, and a method of producing 1,4-butanediol using the same.

Abstract translation: 突变体丁醛脱氢酶（Bld），具有编码突变体的核苷酸的多核苷酸，包含该多核苷酸的载体，包含编码该突变体的核苷酸的微生物，以及使用其的1,4-丁二醇的制造方法。

公开(公告)号：US09416379B2

公开(公告)日：2016-08-16

申请号：US13952410

申请日：2013-07-26

Applicant: Samsung Electronics Co., Ltd.

Inventor： Kyu-sang Lee ,  Young-min Lee ,  Woo-yong Lee ,  Hyun-min Koo ,  Jin-woo Kim ,  Young-kyoung Park ,  Jin-hwan Park ,  Hwa-young Cho ,  Jae-chan Park

IPC: C12N1/20 ,  C12P7/18 ,  C12N15/77 ,  C12N9/04 ,  C12N15/52

CPC classification number: C12P7/18 ,  C12N9/0006 ,  C12N15/52 ,  C12N15/77 ,  C12Y101/01037 ,  C12Y101/05004 ,  Y02P20/52

Abstract: A recombinantly modified Corynebacterium glutamicum microorganism with an improved 1,4-butanediol (1,4-BDO) productivity relative to an unmodified Corynebacterium glutamicum microorganism, wherein activity of an enzyme catalyzing a conversion reaction between malate and oxaloacetate is inactivated or reduced relative to an unmodified Corynebacterium glutamicum microorganism, as well as a method of making and using same.

Abstract translation: 相对于未修饰的谷氨酸棒杆菌微生物，具有改进的1,4-丁二醇（1,4-BDO）生产力的重组修饰的谷氨酸棒杆菌微生物，其中催化苹果酸和草酰乙酸之间的转化反应的酶的活性相对于 未经修饰的谷氨酸棒杆菌微生物，以及其制备和使用方法。