公开(公告)号：US09211512B2

公开(公告)日：2015-12-15

申请号：US14026805

申请日：2013-09-13

Applicant: Samsung Electronics Co., Ltd.

Inventor： Min Seok S. Kim ,  Jong-myeon Park

IPC: B01F11/02 ,  B01F11/00 ,  B01L3/00 ,  B01F13/00 ,  G01N21/03 ,  G01N21/64 ,  G01N15/14

CPC classification number: B01F11/002 ,  B01F11/0002 ,  B01F13/0059 ,  B01L3/50273 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0677 ,  B01L2400/084 ,  G01N21/03 ,  G01N21/6428 ,  G01N2015/149

Abstract: A microfluidic apparatus capable of being mounted on a rotation driving unit. When mounted on the rotation driving unit and rotated, a fluid flow is induced in the apparatus due to a centrifugal force. the microfluidic apparatus includes a sample supplying unit that comprises a sample chamber to house a sample and provides a fluid including a target material in which fine beads are bound to a target cell in the sample; a density-gradient separation unit that houses a density gradient material with a lower density than the target material, and receives the fluid from the sample supplying unit to separate the target material from the fluid based on a density difference; a fluid supplying channel connecting the sample supplying unit to the density-gradient separation unit to form a passage of the fluid; and a fluid supplying valve provided to the fluid supplying channel to selectively allow a flow of the fluid.

Abstract translation: 一种能够安装在旋转驱动单元上的微流体装置。 当安装在旋转驱动单元上并旋转时，由于离心力而在设备中引起流体流动。 所述微流体装置包括样品供应单元，所述样品供应单元包括样品室以容纳样品并提供包含目标材料的流体，在所述样品中，细小珠结合到样品中的靶细胞; 密度梯度分离单元，其容纳具有比目标材料低的密度的密度梯度材料，并且从所述样品供应单元接收流体，以基于密度差从所述流体分离所述目标材料; 流体供给通道，其将样品供给单元连接到密度梯度分离单元，以形成流体的通道; 以及设置到流体供应通道以选择性地允许流体流动的流体供应阀。