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    Sample analysis methods and apparatuses and dynamic valve operation methods
    1.
    发明授权
    Sample analysis methods and apparatuses and dynamic valve operation methods 有权
    样品分析方法和装置以及动态瓣膜操作方法

    公开(公告)号：US09557316B2

    公开(公告)日：2017-01-31

    申请号：US14261708

    申请日：2014-04-25

    Applicant: Samsung Electronics Co., Ltd.

    Inventor： Minseok S. Kim ,  Hui-sung Moon ,  Jong-myeon Park

    IPC: B01L3/00 ,  G01N21/00 ,  G05B15/00 ,  G01N33/49 ,  G01N33/574 ,  F16K99/00

    CPC classification number: G01N33/491 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502753 ,  B01L2200/0652 ,  B01L2200/10 ,  B01L2200/14 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2300/1861 ,  B01L2400/0409 ,  B01L2400/0677 ,  F16K99/0001 ,  F16K2099/0084 ,  Y10T436/25375

    Abstract: Disclosed are sample analysis apparatus and methods. A sample analysis apparatus includes a first unit that rotates a microfluidic apparatus including: a chamber having a space accommodating a sample, a channel that provides a path through which the sample flows; and a valve that selectively opens and closes the channel, a valve driver that supplies energy, used to operate the valve, to the valve in a state of being separated from the microfluidic apparatus, a third unit that rotates the valve driver with respect to a common rotation axis with a rotation axis of the microfluidic apparatus and the third unit, and a control unit that controls the first and third units and the valve driver to supply energy to the valve while the microfluidic apparatus and the valve driver are being rotated at the same rotation speed.

    Abstract translation: 公开的是样品分析装置和方法。 样品分析装置包括旋转微流体装置的第一单元，包括：具有容纳样品的空间的腔室，提供样品流过的路径的通道; 以及选择性地打开和关闭所述通道的阀，在与所述微流体装置分离的状态下向所述阀提供用于操作所述阀的能量的阀驱动器，使所述阀驱动器相对于所述阀驱动器旋转的第三单元 具有微流体装置和第三单元的旋转轴的共同旋转轴，以及控制单元，其控制第一和第三单元和阀驱动器在微流体装置和阀驱动器正在旋转时向阀提供能量 相同的转速。

    Microfluidic apparatus and method of enriching target cells by using the same
    2.
    发明授权
    Microfluidic apparatus and method of enriching target cells by using the same 有权
    微流控装置及其使用方法

    公开(公告)号：US09211512B2

    公开(公告)日：2015-12-15

    申请号：US14026805

    申请日：2013-09-13

    Applicant: Samsung Electronics Co., Ltd.

    Inventor： Min Seok S. Kim ,  Jong-myeon Park

    IPC: B01F11/02 ,  B01F11/00 ,  B01L3/00 ,  B01F13/00 ,  G01N21/03 ,  G01N21/64 ,  G01N15/14

    CPC classification number: B01F11/002 ,  B01F11/0002 ,  B01F13/0059 ,  B01L3/50273 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0677 ,  B01L2400/084 ,  G01N21/03 ,  G01N21/6428 ,  G01N2015/149

    Abstract: A microfluidic apparatus capable of being mounted on a rotation driving unit. When mounted on the rotation driving unit and rotated, a fluid flow is induced in the apparatus due to a centrifugal force. the microfluidic apparatus includes a sample supplying unit that comprises a sample chamber to house a sample and provides a fluid including a target material in which fine beads are bound to a target cell in the sample; a density-gradient separation unit that houses a density gradient material with a lower density than the target material, and receives the fluid from the sample supplying unit to separate the target material from the fluid based on a density difference; a fluid supplying channel connecting the sample supplying unit to the density-gradient separation unit to form a passage of the fluid; and a fluid supplying valve provided to the fluid supplying channel to selectively allow a flow of the fluid.

    Abstract translation: 一种能够安装在旋转驱动单元上的微流体装置。 当安装在旋转驱动单元上并旋转时，由于离心力而在设备中引起流体流动。 所述微流体装置包括样品供应单元，所述样品供应单元包括样品室以容纳样品并提供包含目标材料的流体，在所述样品中，细小珠结合到样品中的靶细胞; 密度梯度分离单元，其容纳具有比目标材料低的密度的密度梯度材料，并且从所述样品供应单元接收流体，以基于密度差从所述流体分离所述目标材料; 流体供给通道，其将样品供给单元连接到密度梯度分离单元，以形成流体的通道; 以及设置到流体供应通道以选择性地允许流体流动的流体供应阀。

    MICROFLUIDIC APPARATUS
    3.
    发明申请
    MICROFLUIDIC APPARATUS 有权
    微流体装置

    公开(公告)号：US20150064774A1

    公开(公告)日：2015-03-05

    申请号：US14273697

    申请日：2014-05-09

    Applicant: Samsung Electronics Co., Ltd.

    Inventor： Hui-sung MOON ,  Min-Seok S. Kim ,  Jong-myeon Park

    IPC: G01N33/574 ,  B01L3/00

    CPC classification number: B01L3/502738 ,  B01L3/50273 ,  B01L2200/0621 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0677

    Abstract: A microfluidic apparatus mounted on a rotation driving unit for inducing a fluid to flow due to a centrifugal force includes: a target chamber that houses a first fluid; a first chamber that houses a second fluid and is disposed closer to a rotation center of the microfluidic apparatus in a radius direction than the target chamber, the first chamber being connected to the target chamber by a first channel; a first valve that prevents a flow of the second fluid through the first channel; and a second chamber disposed closer to the rotation center in the radius direction than the target chamber and connected to the target chamber by a second channel, wherein the first fluid is transported to the second chamber by supplying the second fluid to the target chamber by the centrifugal force.

    Abstract translation: 安装在旋转驱动单元上的用于引起流体由于离心力而流动的微流体装置包括：容纳第一流体的目标室; 第一室，其容纳第二流体并且设置成比所述目标室更靠近所述微流体装置的旋转中心，所述第一室通过第一通道连接到所述目标室; 第一阀，其防止第二流体流过第一通道; 以及第二室，其在半径方向上比目标室更靠近旋转中心设置，并且通过第二通道连接到目标室，其中通过将第二流体供应到目标室，将第一流体输送到第二腔室 离心力。

    SAMPLE ANALYSIS METHODS AND APPARATUSES AND DYNAMIC VALVE OPERATION METHODS
    9.
    发明申请
    SAMPLE ANALYSIS METHODS AND APPARATUSES AND DYNAMIC VALVE OPERATION METHODS 有权
    样品分析方法与装置及动态阀的运行方法

    公开(公告)号：US20150104814A1

    公开(公告)日：2015-04-16

    申请号：US14261708

    申请日：2014-04-25

    Applicant: Samsung Electronics Co., Ltd.

    Inventor： Minseok S. KIM ,  Hui-sung Moon ,  Jong-myeon Park

    IPC: B01L3/00 ,  G01N33/49 ,  G01N33/574

    CPC classification number: G01N33/491 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502753 ,  B01L2200/0652 ,  B01L2200/10 ,  B01L2200/14 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2300/1861 ,  B01L2400/0409 ,  B01L2400/0677 ,  F16K99/0001 ,  F16K2099/0084 ,  Y10T436/25375

    Abstract: Disclosed are sample analysis apparatus and methods. A sample analysis apparatus includes a first unit that rotates a microfluidic apparatus including: a chamber having a space accommodating a sample, a channel that provides a path through which the sample flows; and a valve that selectively opens and closes the channel, a valve driver that supplies energy, used to operate the valve, to the valve in a state of being separated from the microfluidic apparatus, a third unit that rotates the valve driver with respect to a common rotation axis with a rotation axis of the microfluidic apparatus and the third unit, and a control unit that controls the first and third units and the valve driver to supply energy to the valve while the microfluidic apparatus and the valve driver are being rotated at the same rotation speed.

    Abstract translation: 公开的是样品分析装置和方法。 样品分析装置包括旋转微流体装置的第一单元，包括：具有容纳样品的空间的腔室，提供样品流过的路径的通道; 以及选择性地打开和关闭所述通道的阀，在与所述微流体装置分离的状态下向所述阀提供用于操作所述阀的能量的阀驱动器，使所述阀驱动器相对于所述阀驱动器旋转的第三单元 具有微流体装置和第三单元的旋转轴的共同旋转轴，以及控制单元，其控制第一和第三单元和阀驱动器在微流体装置和阀驱动器正在旋转时向阀提供能量 相同的转速。

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