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12 条记录 (耗时 0.033 秒)

    Tie-2 ligands
    5.
    发明授权
    Tie-2 ligands 有权
    Tie-2配体

    公开(公告)号：US06433143B1

    公开(公告)日：2002-08-13

    申请号：US08817318

    申请日：1999-09-16

    申请人： Samuel Davis ,  Joanne Bruno ,  Mitchell Goldfarb ,  Thomas H. Aldrich ,  Peter C. Maisonpierre ,  Czeslaw Radziejewski ,  Pamela F. Jones ,  George D. Yancopoulos

    发明人： Samuel Davis ,  Joanne Bruno ,  Mitchell Goldfarb ,  Thomas H. Aldrich ,  Peter C. Maisonpierre ,  Czeslaw Radziejewski ,  Pamela F. Jones ,  George D. Yancopoulos

    IPC分类号： C07K1452

    CPC分类号： C07K14/515 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body, which specifically binds a human TIE-2 ligand. The invention also provides an antibody that specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.

    摘要翻译： 本发明提供了编码人TIE-2配体的分离的核酸分子。 此外，本发明提供了特异性结合人TIE-2配体的受体体。 本发明还提供了特异性结合人TIE-2配体的抗体。 本发明进一步提供人TIE-2的拮抗剂。 本发明还提供治疗组合物以及阻断血管生长的方法，促进新生血管形成的方法，促进表达TIE-2受体的细胞的生长或分化的方法，阻断生长或分化的方法 的表达TIE-2受体的细胞以及减弱或预防人类肿瘤生长的方法。

    TIE-2 ligand, and method of making
    7.
    发明授权
    TIE-2 ligand, and method of making 失效
    TIE-2配体及其制备方法

    公开(公告)号：US5521073A

    公开(公告)日：1996-05-28

    申请号：US330261

    申请日：1994-10-27

    申请人： Samuel Davis ,  Thomas H. Aldrich ,  George D. Yancopoulos

    发明人： Samuel Davis ,  Thomas H. Aldrich ,  George D. Yancopoulos

    IPC分类号： A61K38/00 ,  C07K14/515 ,  C12N15/12 ,  C07K14/00

    CPC分类号： C07K14/515 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention provides for an isolated nucleic acid molecule encoding human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds human TIE-2 ligand. The invention also provides an antibody which specifically binds human TIE-2 ligand. The invention further provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization and a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor.

    摘要翻译： 本发明提供了编码人TIE-2配体的分离的核酸分子。 此外，本发明提供了特异性结合人TIE-2配体的受体体。 本发明还提供了特异性结合人TIE-2配体的抗体。 本发明进一步提供治疗组合物以及阻断血管生长的方法，促进新生血管形成的方法和促进表达TIE-2受体的细胞的生长或分化的方法。

    Assay systems for trkB neurotrophin activity
    8.
    发明授权
    Assay systems for trkB neurotrophin activity 失效
    trkB神经营养因子活性检测系统

    公开(公告)号：US5622862A

    公开(公告)日：1997-04-22

    申请号：US339578

    申请日：1994-11-14

    申请人： Stephen P. Squinto ,  David Glass ,  Thomas H. Aldrich ,  Peter DiStefano ,  Trevor Stitt ,  Mark E. Furth ,  George D. Yancopoulos

    发明人： Stephen P. Squinto ,  David Glass ,  Thomas H. Aldrich ,  Peter DiStefano ,  Trevor Stitt ,  Mark E. Furth ,  George D. Yancopoulos

    IPC分类号： A61K38/00 ,  C07K14/71 ,  C12N15/00 ,  C12N5/10

    CPC分类号： C07K14/71 ,  A61K38/00 ,  G01N2333/475

    摘要： The present invention provides for assay systems that may be used to detect and/or measure neurotrophin activity or to identify agents that exhibit neurotrophin-like activity, and for methods of using such assay systems. It is based, at least in part, on the discovery that the trkB protooncogene encodes a tyrosine kinase receptor that may serve as a functional binding protein for BDNF and NT-3. Such assay systems may be of particular value in identifying new neurotrophins or agents with neurotrophin-like activity. In various embodiments, the assay systems and methods of the invention may be used to detect and/or measure the binding of neurotrophin to trkB, either using direct binding studies or the detection of the secondary affects of trkB/neurotrophin binding. The present invention also has diagnostic and therapeutic utilities. In particular embodiments of the invention, methods of detecting aberrancies in trkB function or expression may be used in the diagnosis of neurological disorders. In other embodiments, manipulation of the trkB/neurotrophin interaction may be used in the treatment of neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (Lou Gehrig's disease).

    摘要翻译： 本发明提供了可用于检测和/或测量神经营养因子活性或鉴定表现出神经营养因子样活性的试剂的测定系统，以及使用该测定系统的方法。 至少部分基于trkB原癌基因编码可能作为BDNF和NT-3的功能性结合蛋白的酪氨酸激酶受体的发现。 鉴定新的神经营养蛋白或具有神经营养蛋白样活性的药剂时，这种测定系统可能是特别有价值的。 在各种实施方案中，本发明的测定系统和方法可以用于使用直接结合研究或trkB /神经营养因子结合的次级影响的检测来检测和/或测量神经营养因子与trkB的结合。 本发明还具有诊断和治疗用途。 在本发明的具体实施方案中，检测trkB功能或表达异常的方法可用于诊断神经障碍。 在其它实施方案中，trkB /神经营养因子相互作用的操作可用于治疗神经障碍，包括阿尔茨海默病，帕金森氏病和肌萎缩性侧索硬化（Lou Gehrig's disease）。