公开(公告)号：US20150015888A1

公开(公告)日：2015-01-15

申请号：US13941389

申请日：2013-07-12

申请人： Sandeep Gulati ,  Thomas George ,  Timothy Ruchti ,  Alan Abul-Haj ,  Kevin H. Hazen

发明人： Sandeep Gulati ,  Thomas George ,  Timothy Ruchti ,  Alan Abul-Haj ,  Kevin H. Hazen

IPC分类号： G01N21/47

CPC分类号： G01J3/42 ,  A61B5/0022 ,  A61B5/1079 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/6801 ,  G01N21/474 ,  G01N2021/4742 ,  G01N2021/4747 ,  G01N2201/0826

摘要： An analyzer apparatus and method of use thereof is described to dynamically irradiate a sample with incident light where the incident light is varied in time in terms of any of: position, radial position relative to a point of the skin of a subject, solid angle, incident angle, depth of focus, energy, and/or intensity. For example, the incident light is varied in radial position as a function of time relative to one or more of a sample site, a point on skin of the subject, a detection optic, and/or a sample volume observed by a detection system. The radially varied incident light is used to enhance and/or vary light probing the epidermis, the dermis, and/or the subcutaneous fat of the subject or of a group of subjects.

摘要翻译： 描述了一种分析装置及其使用方法，用入射光动态地照射入射光，其中入射光随时间变化，即：相对于被摄体的皮肤的立体角度的位置，径向位置， 入射角，焦深，能量和/或强度。 例如，相对于样本部位，受试者的皮肤上的点，检测光学部件和/或由检测系统观察到的样品体积，入射光在径向位置上作为时间的函数而变化。 径向变化的入射光用于增强和/或变化探测受试者或一组受试者的表皮，真皮和/或皮下脂肪的光。

公开(公告)号：US20150018646A1

公开(公告)日：2015-01-15

申请号：US13941411

申请日：2013-07-12

申请人： Sandeep Gulati ,  Thomas George ,  Timothy Ruchti ,  Alan Abul-Haj ,  Kevin H. Hazen

发明人： Sandeep Gulati ,  Thomas George ,  Timothy Ruchti ,  Alan Abul-Haj ,  Kevin H. Hazen

IPC分类号： A61B5/1455 ,  A61B5/145 ,  A61B5/107

CPC分类号： G01J3/42 ,  A61B5/0022 ,  A61B5/1079 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/6801 ,  G01N21/474 ,  G01N2021/4742 ,  G01N2021/4747 ,  G01N2201/0826

摘要： A noninvasive analyzer apparatus and method of use thereof is described using a sample mapping phase to establish one or more analyzer/software parameters used in a subsequent individual and/or group specific data collection phase. For example, in the sample mapping phase distance between incident and collected light is varied as a function of time for collected noninvasive spectra. Spectra collected in the sample mapping phase are analyzed to determine a physiological property of the subject, such as dermal thickness, hydration, collagen density, epidermal thickness, and/or subcutaneous fat depth. Using the physiological property or measure thereof, the analyzer is optically reconfigured for the individual to yield subsequent spectra having enhanced features for noninvasive analyte property determination. Similarly, in the mapping and/or collection phase, the incident light is varied in time in terms of any of: sample probe position, incident light solid angle, incident light angle, depth of focus, energy, and/or intensity.

摘要翻译： 使用样本映射阶段来描述非侵入性分析仪装置及其使用方法，以建立在随后的个体和/或组特定数据收集阶段中使用的一个或多个分析器/软件参数。 例如，在样本映射中，入射光和收集光之间的距离随收集的无创光谱的时间而变化。 分析在样品测绘阶段收集的光谱，以确定受试者的生理性质，例如真皮厚度，水合，胶原密度，表皮厚度和/或皮下脂肪深度。 使用生理特性或其测量方式，分析仪对于个体进行光学重新配置，以产生具有用于非侵入性分析物质确定的增强特征的后续光谱。 类似地，在映射和/或收集阶段，入射光在时间上根据以下任一种而变化：样本探针位置，入射光立体角，入射光角，焦深，能量和/或强度。

公开(公告)号：US20150018642A1

公开(公告)日：2015-01-15

申请号：US13941369

申请日：2013-07-12

申请人： Sandeep Gulati ,  Thomas George ,  Timothy Ruchti ,  Alan Abul-Haj ,  Kevin H. Hazen

发明人： Sandeep Gulati ,  Thomas George ,  Timothy Ruchti ,  Alan Abul-Haj ,  Kevin H. Hazen

IPC分类号： A61B5/1455 ,  A61B5/00 ,  A61B5/145

CPC分类号： G01J3/42 ,  A61B5/0022 ,  A61B5/1079 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/6801 ,  G01N21/474 ,  G01N2021/4742 ,  G01N2021/4747 ,  G01N2201/0826

摘要： An analyzer apparatus and method of use thereof is configured to dynamically interrogate a sample. For example, an analyzer using light interrogates a tissue sample using a temporal resolution system on a time scale of less than about one hundred nanoseconds. Optionally, near-infrared photons are introduced to a sample with a known illumination zone to detection zone distance allowing calculation of parameters related to photon pathlength in tissue and/or molar absorptivity of an individual or group through the use of the speed of light and/or one or more indices of refraction. Optionally, more accurate estimation of tissue properties are achieved through use of: knowledge of incident photon angle relative to skin, angularly resolved detector positions, anisotropy, skin temperature, environmental information, information related to contact pressure, blood glucose concentration history, and/or a skin layer thickness, such as that of the epidermis and dermis.

摘要翻译： 分析装置及其使用方法被配置为动态询问样品。 例如，使用光的分析器使用时间分辨率系统在小于约百纳秒的时间尺度上询问组织样品。 可选地，将近红外光子引入具有已知照明区域到检测区距离的样品，允许通过使用光速和/或光速计算与组织中的光子路径长度和/或个体或组的摩尔吸光度相关的参数， 或一个或多个折射率。 任选地，通过使用以下方式实现对组织性质的更准确的估计：相对于皮肤的入射光子角度的知识，角度分辨的检测器位置，各向异性，皮肤温度，环境信息，与接触压力相关的信息，血糖浓度历史和/或 皮肤层厚度，如表皮和真皮层。

公开(公告)号：US20150045636A1

公开(公告)日：2015-02-12

申请号：US13963925

申请日：2013-08-09

申请人： Vlad Novotny ,  Sandeep Gulati ,  Thomas George ,  Timothy Ruchti ,  Alan Abul-Haj ,  Kevin H. Hazen

发明人： Vlad Novotny ,  Sandeep Gulati ,  Thomas George ,  Timothy Ruchti ,  Alan Abul-Haj ,  Kevin H. Hazen

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1455

CPC分类号： G01J3/42 ,  A61B5/0022 ,  A61B5/1079 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/6801 ,  G01N21/474 ,  G01N2021/4742 ,  G01N2021/4747 ,  G01N2201/0826

摘要： A noninvasive analyzer apparatus and method of use thereof is described using a plurality of time resolved sample illumination zones coupled to at least one two-dimensional detector array monitoring a plurality of detection zones. Control of illumination times and/or patterns along with selected detection zones yields pathlength resolved groups of spectra. Sectioned pixels and/or zones of the detector are optionally filtered for different light throughput as a function of wavelength. The pathlength resolved groups of spectra are subsequently analyzed to determine an analyte property. Optionally, in the mapping and/or collection phase, incident light is controllably varied in time in terms of any of: sample probe position, incident light solid angle, incident light angle, depth of focus, energy, intensity, and/or detection angle. Optionally, one or more physiological property and/or model property related to a physiological property is used in the analyte property determination.

摘要翻译： 使用耦合到监视多个检测区域的至少一个二维检测器阵列的多个时分解样本照明区域来描述非侵入性分析仪装置及其使用方法。 照射时间和/或图案与所选检测区域的控制产生光程长度解析组。 选择性地检测检测器的截面像素和/或区域作为波长的函数的不同光通量。 随后分析路径长度解析的光谱组以确定分析物质。 可选地，在映射和/或收集阶段，入射光可以根据以下任何方式在时间上可控地变化：样本探针位置，入射光立体角，入射光角，焦深，能量，强度和/或检测角 。 任选地，在分析物质性测定中使用与生理特性相关的一种或多种生理特性和/或模型性质。

公开(公告)号：US20150041656A1

公开(公告)日：2015-02-12

申请号：US13963933

申请日：2013-08-09

申请人： Vlad Novotny ,  Sandeep Gulati ,  Thomas George ,  Timothy Ruchti ,  Alan Abul-Haj ,  Kevin H. Hazen

发明人： Vlad Novotny ,  Sandeep Gulati ,  Thomas George ,  Timothy Ruchti ,  Alan Abul-Haj ,  Kevin H. Hazen

IPC分类号： G01J3/42 ,  A61B5/145 ,  A61B5/1455

CPC分类号： G01J3/42 ,  A61B5/0022 ,  A61B5/1079 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/6801 ,  G01N21/474 ,  G01N2021/4742 ,  G01N2021/4747 ,  G01N2201/0826

摘要： A noninvasive analyzer apparatus and method of use thereof is described using a plurality of time resolved sample illumination zones coupled to at least one two-dimensional detector array monitoring a plurality of detection zones. Control of illumination times and/or patterns along with selected detection zones yields pathlength resolved groups of spectra. Sectioned pixels and/or zones of the detector are optionally filtered for different light throughput as a function of wavelength. The pathlength resolved groups of spectra are subsequently analyzed to determine an analyte property. Optionally, in the mapping and/or collection phase, incident light is controllably varied in time in terms of any of: sample probe position, incident light solid angle, incident light angle, depth of focus, energy, intensity, and/or detection angle. Optionally, one or more physiological property and/or model property related to a physiological property is used in the analyte property determination.

摘要翻译： 使用耦合到监视多个检测区域的至少一个二维检测器阵列的多个时分解样本照明区域来描述非侵入性分析仪装置及其使用方法。 照射时间和/或图案与所选检测区域的控制产生光程长度解析组。 选择性地检测检测器的截面像素和/或区域作为波长的函数的不同光通量。 随后分析路径长度解析的光谱组以确定分析物质。 可选地，在映射和/或收集阶段，入射光可以根据以下任何方式在时间上可控地变化：样本探针位置，入射光立体角，入射光角，焦深，能量，强度和/或检测角 。 任选地，在分析物质性测定中使用与生理特性相关的一种或多种生理特性和/或模型性质。

公开(公告)号：US20150018644A1

公开(公告)日：2015-01-15

申请号：US14504065

申请日：2014-10-01

申请人： Sandeep Gulati ,  Timothy Ruchti ,  Alan Abul-Haj ,  Thomas George ,  Kevin Hazen

发明人： Sandeep Gulati ,  Timothy Ruchti ,  Alan Abul-Haj ,  Thomas George ,  Kevin Hazen

IPC分类号： A61B5/145 ,  G01J5/10 ,  G01J5/08 ,  A61B5/1455

CPC分类号： A61B5/14532 ,  A61B5/0022 ,  A61B5/1079 ,  A61B5/1455 ,  A61B5/6801 ,  G01J3/0218 ,  G01J3/2803 ,  G01J3/36 ,  G01J3/42 ,  G01N21/359 ,  G01N2021/317 ,  G01N2201/062

摘要： A noninvasive analyzer apparatus and method of use thereof is described comprising a near-infrared source, a non-uniform detector array, and a photon transport system configured to direct photons from the source to the detector via an analyzer-sample optical interface. The non-uniform detector array provides a multitude of distinguishable optical pathlengths, couples to a plurality of optical transmission filters, couples to a plurality of light directing micro-optics, and/or couples to an array of light-emitting diodes.

摘要翻译： 描述了一种非侵入性分析仪装置及其使用方法，其包括近红外源，不均匀检测器阵列和配置成经由分析仪样品光学界面将光子从源引导到检测器的光子传输系统。 非均匀检测器阵列提供多种可区别的光程长度，耦合到多个光传输滤波器，耦合到多个光导微光学器件，和/或耦合到发光二极管阵列。

公开(公告)号：US07697966B2

公开(公告)日：2010-04-13

申请号：US11361143

申请日：2006-02-23

申请人： Stephen L. Monfre ,  Thomas B. Blank ,  Kevin H. Hazen ,  Alan Abul-Haj ,  Tim Ruchti ,  James Ryan Henderson ,  Tim Stippick ,  Roxanne Abul-Haj

发明人： Stephen L. Monfre ,  Thomas B. Blank ,  Kevin H. Hazen ,  Alan Abul-Haj ,  Tim Ruchti ,  James Ryan Henderson ,  Tim Stippick ,  Roxanne Abul-Haj

IPC分类号： A61B5/1455

CPC分类号： A61B5/14532 ,  A61B5/061 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/489 ,  A61B5/7264 ,  A61B2562/0242 ,  A61B2562/146

摘要： The invention provides a targeting system used to direct a measuring system to a targeted sample site or volume. The targeting system increases analyte estimation performance by increasing precision and accuracy of sampling and/or by targeting an analyte rich tissue volume.

摘要翻译： 本发明提供了一种用于将测量系统引导到目标样品位点或体积的靶向系统。 靶向系统通过提高采样的精度和准确度和/或通过靶向富含分析物的组织体积来增加分析物估计性能。

公开(公告)号：US20150011849A1

公开(公告)日：2015-01-08

申请号：US14493266

申请日：2014-09-22

申请人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen

发明人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen

IPC分类号： A61B5/1455 ,  A61B5/00 ,  A61B5/145

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/6801 ,  A61B2562/04 ,  A61B2562/046

摘要： A noninvasive analyzer apparatus and method of use thereof is described using a plurality of sample illumination zones optically coupled to at least two optically stacked two-dimensional optical filter arrays. Sectioned pixels and/or zones of a detector array are optionally filtered for different light throughput and/or are passed through various pathlengths using the stacked two-dimensional optical filter arrays. Resulting pathlength resolved/wavelength controlled groups of spectra are subsequently analyzed to determine an analyte property.

摘要翻译： 使用光学耦合到至少两个光学堆叠的二维光学滤波器阵列的多个采样照明区域来描述非侵入性分析仪装置及其使用方法。 可选地，为了不同的光通过量滤波检测器阵列的截面像素和/或区域，和/或使用堆叠的二维光学滤波器阵列通过各种路径长度。 随后分析得到的光程长度解析/波长控制的光谱组，以确定分析物质。

公开(公告)号：US09375170B2

公开(公告)日：2016-06-28

申请号：US14938688

申请日：2015-11-11

申请人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen

发明人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen

IPC分类号： G01N5/02 ,  A61B5/1455 ,  A61B5/145 ,  A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/6801 ,  A61B2562/04 ,  A61B2562/046

摘要： A noninvasive analyzer apparatus and method of use thereof is described using a plurality of sample illumination zones optically coupled to at least two optically stacked two-dimensional optical filter arrays. Sectioned pixels and/or zones of a detector array are optionally filtered for different light throughput and/or are passed through various pathlengths using the stacked two-dimensional optical filter arrays. Resulting pathlength resolved/wavelength controlled groups of spectra are subsequently analyzed to determine an analyte property.

摘要翻译： 使用光学耦合到至少两个光学堆叠的二维光学滤波器阵列的多个采样照明区域来描述非侵入性分析仪装置及其使用方法。 可选地，为了不同的光通过量滤波检测器阵列的截面像素和/或区域，和/或使用堆叠的二维光学滤波器阵列通过各种路径长度。 随后分析得到的光程长度解析/波长控制的光谱组，以确定分析物质。

公开(公告)号：US20160151002A1

公开(公告)日：2016-06-02

申请号：US14943990

申请日：2015-11-17

申请人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen

发明人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen

IPC分类号： A61B5/1455 ,  A61B5/145

CPC分类号： A61B5/14532 ,  A61B5/1455 ,  A61B5/6801 ,  A61B2562/04 ,  A61B2562/046

摘要： A noninvasive analyzer apparatus and method of use thereof is described comprising a near-infrared source, a detector, and a photon transport system configured to direct photons from the source to the detector via an analyzer-sample optical interface. The photon transport system includes a dynamically position light directing unit used to, within a measurement time period for a single analyte concentration determination, change any of: radius, energy, intensity, position, incident angle, solid angle, and/or depth of penetration of a beam of photons entering skin of a subject.