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1.发明授权Multifunctional radical quenchers for the treatment of mitochondrial dysfunction 有权多功能自由基猝灭剂治疗线粒体功能障碍公开(公告)号：US09388163B2
公开(公告)日：2016-07-12
申请号：US14731950
申请日：2015-06-05
Applicant: Sidney Hecht , Omar Khdour , Sandipan Roy Chowdhury , Poulami Talukder
Inventor： Sidney Hecht , Omar Khdour , Sandipan Roy Chowdhury , Poulami Talukder
IPC: C07D279/20 , C07D213/74 , C07D211/94 , C07D401/06 , G01N33/50 , C07D213/89 , C07D279/18
CPC classification number: C07D401/06 , C07D211/94 , C07D213/74 , C07D213/89 , C07D279/18 , C07D279/20 , G01N33/5079
Abstract: The present disclosure provides methods for identifying therapeutic agents that are multifunctional radical quenchers. It also provides compounds of formula: and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
Abstract translation: 本公开提供了用于鉴定作为多功能自由基猝灭剂的治疗剂的方法。 它还提供式：及其药学上可接受的盐的化合物，包含这些化合物的组合物，以及在各种应用中使用这些化合物的方法，例如治疗或抑制与减少的线粒体功能相关的疾病，导致ATP产生减少和/或 氧化应激和/或脂质过氧化。
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2.发明申请公开(公告)号：US20140038963A1
公开(公告)日：2014-02-06
申请号：US14009437
申请日：2012-04-04
Applicant: Sidney Hecht , Omar Khdour , Sandipan Roy Chowdhury , Poulami Talukder
Inventor： Sidney Hecht , Omar Khdour , Sandipan Roy Chowdhury , Poulami Talukder
IPC: C07D211/94 , C07D279/20 , C07D401/06 , G01N33/50
CPC classification number: C07D401/06 , C07D211/94 , C07D213/74 , C07D213/89 , C07D279/18 , C07D279/20 , G01N33/5079
Abstract: The present disclosure provides methods for identifying therapeutic agents that are multifunctional radical quenchers. It also provides compounds of formula (I), (II), or (II-A): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
Abstract translation: 本公开提供了用于鉴定作为多功能自由基猝灭剂的治疗剂的方法。 它还提供式（I），（II）或（II-A）的化合物及其药学上可接受的盐，包含这些化合物的组合物，以及在各种应用中使用这些化合物的方法，例如治疗或抑制 与线粒体功能降低相关的疾病导致ATP产生和/或氧化应激和/或脂质过氧化降低。
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3.发明申请公开(公告)号：US20150266851A1
公开(公告)日：2015-09-24
申请号：US14731950
申请日：2015-06-05
Applicant: Sidney Hecht , Omar Khdour , Sandipan Roy Chowdhury , Poulami Talukder
Inventor： Sidney Hecht , Omar Khdour , Sandipan Roy Chowdhury , Poulami Talukder
IPC: C07D401/06 , C07D279/18 , C07D213/89
CPC classification number: C07D401/06 , C07D211/94 , C07D213/74 , C07D213/89 , C07D279/18 , C07D279/20 , G01N33/5079
Abstract: The present disclosure provides methods for identifying therapeutic agents that are multifunctional radical quenchers. It also provides compounds of formula (I), (II), or (II-A): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
Abstract translation: 本公开提供了用于鉴定作为多功能自由基猝灭剂的治疗剂的方法。 它还提供式（I），（II）或（II-A）的化合物及其药学上可接受的盐，包含这些化合物的组合物，以及在各种应用中使用这些化合物的方法，例如治疗或抑制 与线粒体功能降低相关的疾病导致ATP产生和/或氧化应激和/或脂质过氧化降低。
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4.发明授权Multifunctional radical quenchers for the treatment of mitochondrial dysfunction 有权多功能自由基猝灭剂治疗线粒体功能障碍公开(公告)号：US09334250B2
公开(公告)日：2016-05-10
申请号：US14432885
申请日：2013-10-02
Applicant: Sandipan Roy Chowdhury , Omar Khdour , Sidney Hecht
Inventor： Sandipan Roy Chowdhury , Omar Khdour , Sidney Hecht
IPC: C07D279/16
CPC classification number: C07D279/16
Abstract: The present disclosure provides compounds of formula (I): compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
Abstract translation: 本公开内容提供了式（I）化合物：包含这些化合物的组合物，以及在各种应用中使用这些化合物的方法，例如治疗或抑制与线粒体功能降低相关的疾病，导致ATP产生和/或氧化应激减少 和/或脂质过氧化。
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Patent Agency Ranking
5.发明授权Multifunctional radical quenchers for the treatment of mitochondrial dysfunction 有权多功能自由基猝灭剂治疗线粒体功能障碍公开(公告)号：US09102626B2
公开(公告)日：2015-08-11
申请号：US14009437
申请日：2012-04-04
Applicant: Sidney Hecht , Omar Khdour , Sandipan Roy Chowdhury , Poulami Talukder
Inventor： Sidney Hecht , Omar Khdour , Sandipan Roy Chowdhury , Poulami Talukder
IPC: C07D211/94 , C07D213/74 , C07D279/20 , C07D401/06 , G01N33/50
CPC classification number: C07D401/06 , C07D211/94 , C07D213/74 , C07D213/89 , C07D279/18 , C07D279/20 , G01N33/5079
Abstract: The present disclosure provides methods for identifying therapeutic agents that are multifunctional radical quenchers. It also provides compounds of formula (I), (II), or (II-A): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
Abstract translation: 本公开提供了用于鉴定作为多功能自由基猝灭剂的治疗剂的方法。 它还提供式（I），（II）或（II-A）的化合物及其药学上可接受的盐，包含这些化合物的组合物，以及在各种应用中使用这些化合物的方法，例如治疗或抑制 与线粒体功能降低相关的疾病导致ATP产生和/或氧化应激和/或脂质过氧化降低。
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![1H-pyrrolo [2, 3 -B] pyridine derivatives and their use as radical quenchers](/abs-image/US/2016/09/13/US09440967B2/abs.jpg.150x150.jpg)
6.发明授权1H-pyrrolo [2, 3 -B] pyridine derivatives and their use as radical quenchers 有权1H-吡咯并[2,3-b]吡啶衍生物及其用作自由基猝灭剂公开(公告)号：US09440967B2
公开(公告)日：2016-09-13
申请号：US14371579
申请日：2013-02-11
Applicant: Sidney Hecht , Xiaoqing Cai , Omar Khdour , Jose I. Armendariz Guajardo
Inventor： Sidney Hecht , Xiaoqing Cai , Omar Khdour , Jose I. Armendariz Guajardo
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: The present disclosure provides biologically active compounds of formula (I): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
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公开(公告)号：US20150274628A1
公开(公告)日：2015-10-01
申请号：US14434725
申请日：2013-10-10
Applicant: Manikandadas, Mathilakathu MADATHIL , Omar KHDOUR , Sidney HECHT , ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AN ON BEHALF OF ARIZO
Inventor： Manikandadas Mathilakathu Madathil , Omar Khdour , Sidney Hecht
IPC: C07C49/753 , C07C229/10 , C07D225/06 , C07C225/20
CPC classification number: C07C49/753 , A61K9/0019 , A61K9/008 , A61K9/08 , A61K9/2018 , A61K9/2054 , A61K9/4858 , C07C46/02 , C07C225/20 , C07C229/10 , C07D225/06 , C07C50/28
Abstract: The invention provides a compound of formula (I): [insert formula (I)] wherein X, Y, and R1-R4 have any of the values defined in the specification, and salts thereof, as well as compositions comprising the compounds or salts. The compounds are useful for treating diseases associated with impaired mitochondrial function in an animal.
Abstract translation: 本发明提供式（I）化合物：[插入式（I）]其中X，Y和R 1 -R 4具有说明书中定义的任何值及其盐，以及包含化合物或盐的组合物 。 该化合物可用于治疗与动物线粒体功能受损相关的疾病。
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![1H-Pyrrolo [2, 3 -B] Pyridine Derivatives and Their Use as Radical Quenchers](/abs-image/US/2015/01/08/US20150011580A1/abs.jpg.150x150.jpg)
8.发明申请1H-Pyrrolo [2, 3 -B] Pyridine Derivatives and Their Use as Radical Quenchers 有权1H-吡咯并[2,3-b]吡啶衍生物及其用作自由基猝灭剂公开(公告)号：US20150011580A1
公开(公告)日：2015-01-08
申请号：US14371579
申请日：2013-02-11
Applicant: Jose I. Armendariz Guajardo , Sidney Hecht , Omar Khdour , Xiaoqing Cai
Inventor： Jose I. Armendariz Guajardo , Sidney Hecht , Omar Khdour , Xiaoqing Cai
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: The present disclosure provides biologically active compounds of formula (I): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
Abstract translation: 本公开提供了式（I）的生物活性化合物及其药学上可接受的盐，包含这些化合物的组合物，以及在各种应用中使用这些化合物的方法，例如治疗或抑制与降低的线粒体功能相关的疾病，导致 减少ATP产生和/或氧化应激和/或脂质过氧化。
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公开(公告)号：US08952025B2
公开(公告)日：2015-02-10
申请号：US13855133
申请日：2013-04-02
Applicant: Sidney Hecht , Omar Khdour , Jun Lu , Pablo Arce
Inventor： Sidney Hecht , Omar Khdour , Jun Lu , Pablo Arce
IPC: A01N43/54 , A61K31/505 , C07D239/47 , C07D213/74 , C07D237/22 , C07D239/42 , C07D213/73 , C07D239/52 , C07D403/04 , C07D471/04
CPC classification number: C07D239/47 , C07D213/73 , C07D213/74 , C07D237/22 , C07D239/42 , C07D239/52 , C07D403/04 , C07D471/04
Abstract: The present disclosure provides biologically active compounds of formula (I): and pharmaceutically acceptable salts thereof: compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
Abstract translation: 本公开提供式（I）的生物活性化合物及其药学上可接受的盐：包含这些化合物的组合物，以及在各种应用中使用这些化合物的方法，例如治疗或抑制与线粒体功能降低相关的疾病，导致 减少ATP产生和/或氧化应激和/或脂质过氧化。
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