公开(公告)号：US06211414B1

公开(公告)日：2001-04-03

申请号：US09341835

申请日：1999-08-31

申请人： Sandra Bogdanovic ,  Helmut Bahrmann ,  Carl-Dieter Frohning ,  Ernst Wiebus

发明人： Sandra Bogdanovic ,  Helmut Bahrmann ,  Carl-Dieter Frohning ,  Ernst Wiebus

IPC分类号： C07C4550

CPC分类号： C07C45/50 ,  C07C47/02

摘要： The invention concerns a process for preparing aldehydes by reacting with hydrogen and carbon monoxide at a temperature of between 20 and 170° C. and a pressure of between 1 and 300 bar an olefinically unsaturated C3-C5 compound in the presence of an aqueous phase containing rhodium and sulphonated triarylphosphines as catalyst and between 1 and 35 wt % of a compound of formula (1), R(OCH2CH2)nOR1, R standing for hydrogen, a straight-chain or branched C1-C4 alkyl group or a C1-C4 hydroxyalkyl group, R1 standing for hydrogen or a methyl group, and n standing for an integer from 3 to 50.

摘要翻译： 本发明涉及一种通过在氢和一氧化碳的温度为20至170℃之间以及1-300巴之间的压力下在含有水相的存在下使烯属不饱和C 3 -C 5化合物反应来制备醛的方法 铑和磺化三芳基膦作为催化剂，和1-35重量％的式（1）化合物，R（OCH 2 CH 2）nOR 1，R代表氢，直链或支链C 1 -C 4烷基或C 1 -C 4羟基烷基 基团，R 1表示氢或甲基，n表示3〜50的整数。

公开(公告)号：US06274774B1

公开(公告)日：2001-08-14

申请号：US09341396

申请日：1999-08-30

申请人： Sandra Bogdanovic ,  Carl-Dieter Frohning ,  Helmut Bahrmann

发明人： Sandra Bogdanovic ,  Carl-Dieter Frohning ,  Helmut Bahrmann

IPC分类号： C07C4550

CPC分类号： B01J31/2404 ,  B01J31/068 ,  B01J31/2409 ,  B01J31/2447 ,  B01J31/2452 ,  B01J2231/321 ,  B01J2531/0266 ,  B01J2531/822 ,  B01J2531/96 ,  B01J2540/32 ,  C07C45/50 ,  C07F9/5027 ,  C07C47/225 ,  C07C47/45

摘要： The invention concerns a process for preparing aldehydes by reacting with hydrogen and carbon monoxide at a temperature of between 20 and 170° C. and a pressure of between 1 and 300 bar an olefinically unsaturated C6-C16 compound in the presence aqueous phase containing rhodium and sulphonated triarylphosphines as catalyst and between 10 and 70 wt % of a compound of formula (1), R(OCH2CH2)nOR1, R standing for hydrogen, a straight-chain or branched C1-C4 alkyl group or a C1-C4 hydroxyalkyl group, R1 standing for hydrogen or a methyl group, and n standing for an integer from 3 to 50.

摘要翻译： 本发明涉及一种通过在氢气和一氧化碳的温度为20〜170℃，压力为1〜300巴之间的烯属不饱和C 6 -C 16化合物与含有铑的水相和 作为催化剂的磺化三芳基膦和10至70重量％的式（1）化合物，R（OCH 2 CH 2）nOR 1，R代表氢，直链或支链C 1 -C 4烷基或C 1 -C 4羟烷基， R1代表氢或甲基，n代表3-50的整数。

公开(公告)号：US06191063B1

公开(公告)日：2001-02-20

申请号：US09230576

申请日：1999-07-01

申请人： Sandra Bogdanovic ,  Carl-Dieter Frohning ,  Helmut Bahrmann ,  Matthias Beller ,  Steffen Haber ,  Hans-Jerg Kleiner

发明人： Sandra Bogdanovic ,  Carl-Dieter Frohning ,  Helmut Bahrmann ,  Matthias Beller ,  Steffen Haber ,  Hans-Jerg Kleiner

IPC分类号： B01J3128

CPC分类号： B01J31/1683 ,  B01J31/2404 ,  B01J31/2409 ,  B01J31/2423 ,  B01J31/2466 ,  B01J2231/321 ,  B01J2531/822 ,  B01J2531/96 ,  C07C45/50 ,  C07F15/008 ,  C07C47/02

摘要： A catalyst comprising rhodium and a compound of the formula (I) in which m is a number from 1 to 1000; x is a number from 0 to 4; W is a group of the formulae —CH2—CH2—, —CH(CH3)CH2—or —CH2CH(CH3)—; R is hydrogen, a straight-chain or branched C1-C5— alkyl radical; or a group of the formulae where a, b, c, d and e independently of one another are a number from 0 to 1000, at least one of the numbers a, b, c, d and e being greater than 0; R5, R6, R7, R8 and R9 are identical or different and are hydrogen, C1-C5-alkyl or a group of the formula R1 and R2 are identical or different and are a straight-chain, branched or cyclic C1-C30-alkyl radical or C6-10-aryl radical, which is unsubstituted or substituted by from one to five C1-C3-alkyl radicals, and L is C1-C5-alkyl, C1-C5-alkoxy, NO2, NR3R4, where R3 and R4 independently of one another are hydrogen or C1-C4-alkyl, or L is Cl or OH, for hydroformylation reactions.

摘要翻译： 一种催化剂，其包含铑和式（I）化合物，其中m为1至1000的数; x为0至4的数; W为式-CH 2 -CH 2 - ， - CH（CH 3） CH2-或-CH2CH（CH3） - ; R是氢，直链或支链C1-C5-烷基; 或一组式，b，c，d和e彼此独立地为0至1000的数，数a，b，c，d和e中的至少一个大于0; R 5，R 6， R 7，R 8和R 9相同或不同，为氢，C 1 -C 5 - 烷基或式R 1和R 2的基团相同或不同，为直链，支链或环状C 1 -C 30 - 烷基或C 6-10 芳基，其是未取代的或被1至5个C 1 -C 3 - 烷基取代，且L是C 1 -C 5 - 烷基，C 1 -C 5 - 烷氧基，NO 2，NR 3 R 4，其中R 3和R 4彼此独立地是氢或 C1-C4烷基，或L是Cl或OH，用于加氢甲酰化反应。

公开(公告)号：US6160180A

公开(公告)日：2000-12-12

申请号：US230538

申请日：1999-04-22

申请人： Steffen Haber ,  Hans-Jerg Kleiner ,  Sandra Bogdanovic ,  Helmut Bahrmann ,  Carl-Dieter Frohning

发明人： Steffen Haber ,  Hans-Jerg Kleiner ,  Sandra Bogdanovic ,  Helmut Bahrmann ,  Carl-Dieter Frohning

IPC分类号： B01J31/24 ,  C07C45/50 ,  C07C303/28 ,  C07C309/66 ,  C07F9/50 ,  C08G65/26 ,  C08G65/334 ,  C08G65/335 ,  C07F9/28 ,  C08F30/02

CPC分类号： B01J31/2404 ,  B01J31/1683 ,  B01J31/2423 ,  B01J31/2466 ,  B01J2231/32 ,  B01J2231/321 ,  B01J2531/80 ,  B01J2531/96 ,  C07C303/28 ,  C07F9/5022 ,  C08G65/3344 ,  C08G65/335 ,  C07C309/66

摘要： A compound is disclosed having the formula (I), in which m equals 1 to 1000; x equals 0 to 4; W is a group of formulas --CH.sub.2 --CH.sub.2 --, --CH(CH.sub.3)CH.sub.2 -- or --CH.sub.2 CH(CH.sub.3)--; R is hydrogen, a straight-chain or branched-chain C.sub.1 -C.sub.5 alkyl radical; or a group of formulas (a) or (b), in which a, b, c, d and e independently represent a number from 0 to 1000, at least one of the numbers represented by a, b, c, d and e being higher than 0; R.sup.5, R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are the same or different and represent hydrogen, C.sub.1 -C.sub.5 alkyl or a group of formula (c); R.sup.1 and R.sup.2 are the same or different and represent a straight-chain, a branched-chain or a cyclic C.sub.1 -C.sub.30 alkyl radical or C.sub.6 -C.sub.10 aryl radical which is non-substituted or substituted by one to five C.sub.1 -C.sub.3 alkyl radicals, or R.sup.1 and R.sup.2 form together with the trivalent P atom form a dibenzophospholyl of formula (d) or a 3,4-dimethylphospholyl of formula (e); and L stands for C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, NO.sub.2, NR.sup.3 R.sup.4, R.sup.3 and R.sup.4 independently representing hydrogen or C.sub.1 -C.sub.4 alkyl, or for Cl or OH. ##STR1##

摘要翻译： PCT No.PCT / EP97 / 03927 Sec。 371日期1999年4月22日 102（e）1999年4月22日PCT 1997年7月21日PCT公布。 出版物WO98 / 04568 日期：1998年2月5日公开了具有式（I）的化合物，其中m等于1至1000; x等于0到4; W是式-CH 2 -CH 2 - ， - CH（CH 3）CH 2 - 或-CH 2 CH（CH 3） - 基团; R是氢，直链或支链的C 1 -C 5烷基; 或一组式（a）或（b），其中a，b，c，d和e独立地表示0至1000的数字，由a，b，c，d和e表示的数字中的至少一个 高于0; R5，R6，R7，R8和R9相同或不同，代表氢，C1-C5烷基或式（c）基团; R 1和R 2相同或不同，表示未被一至五个C 1 -C 3烷基取代或未取代的直链，支链或环状C 1 -C 30烷基或C 6 -C 10芳基， 或者R 1和R 2与三价P原子一起形成式（d）的二苯并双磷酰基或式（e）的3,4-二甲基磷酰基; L代表C1-C5烷基，C1-C5烷氧基，NO2，NR3R4，R3和R4独立代表氢或C1-C4烷基，或C1或OH。

公开(公告)号：US06339174B1

公开(公告)日：2002-01-15

申请号：US09508542

申请日：2000-05-16

申请人： Sandra Bogdanovic

发明人： Sandra Bogdanovic

IPC分类号： C07C4550

CPC分类号： C07C45/50 ,  B01J31/0204 ,  B01J31/0225 ,  B01J31/0267 ,  B01J31/0271 ,  B01J31/068 ,  B01J31/2409 ,  B01J2231/321 ,  B01J2531/822 ,  B01J2531/96 ,  B01J2540/32 ,  C07C47/02

摘要： A catalyst composition comprising a) more than 70% by weight of a polyethylene glycol of the formula H—(OCH2—CH2)n—OH, where n is an integer of 3 to 16 and the number average molecular weight is less than 650 b) rhodium in elemental form or bound form and c) 2 to 25% by weight of water soluble sulfonated triarylphosphine ligand having 1 to 2 phophorus atoms and not more than 25% by weight of water based on the total amount of the catalyst and its use for the hydroformylation of olefins to aldehydes is described.

摘要翻译： 一种催化剂组合物，其包含a）超过70重量％的式H-（OCH 2 -CH 2）n -OH的聚乙二醇，其中n是3-16的整数，数均分子量小于650b ）铑元素形式或结合形式，c）2至25重量％的基于催化剂总量及其用途的具有1至2个磷原子和不超过25重量％水的水溶性磺化三芳基膦配体 描述了烯烃向醛的加氢甲酰化。

公开(公告)号：US5756413A

公开(公告)日：1998-05-26

申请号：US759462

申请日：1996-12-05

申请人： Sandra Bogdanovic ,  Holger Geissler ,  Klaus Raab ,  Matthias Beller ,  Hartmut Fischer

发明人： Sandra Bogdanovic ,  Holger Geissler ,  Klaus Raab ,  Matthias Beller ,  Hartmut Fischer

IPC分类号： B01J31/20 ,  B01J31/40 ,  B01J38/68 ,  C07C231/02 ,  C07C233/47 ,  B01J20/34 ,  B01J38/52 ,  B01J38/64

CPC分类号： B01J31/20 ,  B01J31/403 ,  B01J2231/34 ,  B01J2531/845 ,  B01J31/04 ,  B01J31/26 ,  B01J31/28

摘要： The present invention relates to a process for recovering the cobalt carbonyl catalyst used, in which a water-soluble cobalt salt is first prepared by addition of acid and this is subsequently precipitated as cobalt hydroxide. This cobalt hydroxide is then reacted with the N-acyl-.alpha.-amino acid derivative for whose preparation the cobalt carbonyl catalyst is intended, and the resulting cobalt-containing melt is converted into the cobalt carbonyl catalyst in the presence of a mixture of carbon monoxide and hydrogen.

摘要翻译： 本发明涉及一种用于回收所用的羰基钴催化剂的方法，其中首先通过加入酸制备水溶性钴盐，然后将其随氢氧化钴沉淀。 然后将该氢氧化钴与其制备所需的羰基钴催化剂的N-酰基-α-氨基酸衍生物反应，并将所得含钴熔体在一氧化碳混合物存在下转化为羰基钴催化剂 和氢气。

公开(公告)号：US06388142B1

公开(公告)日：2002-05-14

申请号：US09509143

申请日：2000-05-16

申请人： Sandra Bogdanovic ,  Klaus Kuhlein

发明人： Sandra Bogdanovic ,  Klaus Kuhlein

IPC分类号： C07C4550

CPC分类号： C07C45/50 ,  C07C47/02

摘要： The invention relates to a method for producing aldehydes by reacting one olefine containing 3 to 12 carbon atoms with hydrogen and carbon monoxide in the presence of one rhodium catalyst. The invention is characterized in that (a) the rhodium catalyst is present in an aqueous phase, whereby the aqueous phase contains i) rhodium in an elemental or bonded form, ii) one trisulfonated triaryl phosphine, and iii) one crown etherl (b) the olefine is present in the reaction conditions in a liquid organic phase which cannot be mixed with the aqueous phase.

摘要翻译： 本发明涉及通过在一种铑催化剂存在下使含有3至12个碳原子的烯烃与氢气和一氧化碳反应来生产醛的方法。 本发明的特征在于（a）铑催化剂存在于水相中，其中水相含有i）元素或键合形式的铑，ii）一种三磺化三芳基膦，和iii）一种冠醚（b） 烯烃在反应条件下存在于不能与水相混合的液体有机相中。

公开(公告)号：US06225508B1

公开(公告)日：2001-05-01

申请号：US09462399

申请日：2000-02-15

申请人： Sandra Bogdanovic ,  Herbert Roesky ,  Uwe Ritter ,  Thomas Borrmann

发明人： Sandra Bogdanovic ,  Herbert Roesky ,  Uwe Ritter ,  Thomas Borrmann

IPC分类号： C07C4550

CPC分类号： C07C45/50 ,  B01J31/068 ,  B01J31/165 ,  B01J31/223 ,  B01J2231/321 ,  B01J2531/822 ,  C07C47/02

摘要： According to the invention, branched and straight chain alkenes and cycloalkenes with five and more C-atoms are by means of hydroformylation using a novel rhodium-tri-polyethylene glycolate of a polyethylene glycol with an average molecular weight of 320 to 650 as a catalyst with at hydrogen/carbon monoxide pressure of 60 to 200 bar and at a temperature of between 50 and 150° C. converted into branched and straight chain alkanals and cycloalkanals with six and more C-atoms. The reaction is preferably carried out in water or polyethylene glycol or a mixture of the same as a solvent in the heterogeneous phase. The aldehydes obtained are easy to separate from the catalyst in the reaction preparation. Said aldehydes are also obtained with a high level of purity and a high yield.

摘要翻译： 根据本发明，具有五个以上C原子的支链和直链烯烃和环烯烃通过使用新型的平均分子量为320至650的聚乙二醇铑 - 三聚乙二醇酸作为催化剂进行加氢甲酰化， 在氢气/一氧化碳压力为60至200巴，温度为50至150℃之间，转化成支链和直链链烷烃和具有六个或更多个C原子的环烷烃。 该反应优选在水或聚乙二醇或与异相的溶剂相同的混合物中进行。 所得的醛在反应制备中容易与催化剂分离。 也可以获得高纯度和高产率的所述醛。

公开(公告)号：US06225504B1

公开(公告)日：2001-05-01

申请号：US09331826

申请日：1999-06-23

申请人： Sandra Bogdanovic ,  Matthias Beller ,  Alexander Zapf ,  Jurgen Krauter

发明人： Sandra Bogdanovic ,  Matthias Beller ,  Alexander Zapf ,  Jurgen Krauter

IPC分类号： C07F950

CPC分类号： B01J31/2404 ,  B01J31/20 ,  B01J31/2447 ,  B01J2231/321 ,  B01J2231/4205 ,  B01J2231/4211 ,  B01J2231/4261 ,  B01J2531/0272 ,  B01J2531/821 ,  B01J2531/824 ,  C07H15/203 ,  Y02P20/55

摘要： A process for the preparation of the formula Ar13−xP[(Ar2(OZ)y]x  I wherein Ar1 and Ar2 are individually aromatic of 6 to 20 carbon atoms or heteroaromatic of 4 to 9 carbon atoms, each unsubstituted or substituted with at least one member of the group consisting of halogen, carboxyl, —OH, alkyl of 1 to 6 carbon atoms, phenyl and naphthyl, Ar1 has one valence and R2 has y+1 valences, x is an integer of 1, 2 or 3, y is 1 or 2, Z is carbohydrate with a glycosidic bond comprising reacting a hydrocarbon halide of the formula Z′—X  II when Z′ has the definition of Z with —OH protected and X is chlorine, bromine or fluorine with a phosphane of the formula Ar13−xP[(Ar2 (OH)y]x  III in a multi-phase reaction medium in the presence of a base and a phase transfer catalyst to form a phosphane of the formula Ar13−xP[(Ar2(OZ1)y]x  IV and removal of the protective groups to form a compound of Formula I, metal complexes thereof and various processes.

摘要翻译： 制备糠醛的方法Ar1和Ar2分别为6至20个碳原子的芳族或4至9个碳原子的杂芳族化合物，每个未取代或被至少一个由卤素，羧基，-OH， 具有1至6个碳原子的烷基，苯基和萘基，Ar 1具有一个化合价，R 2具有y + 1价，x是1,2或3的整数，y是1或2，Z是具有糖苷键的碳水化合物， 在碱和相转移催化剂存在下形成多相反应介质的烃卤化物，以形成下式的膦并除去保护基以形成式I化合物，其金属络合物和各种方法。

公开(公告)号：US6162753A

公开(公告)日：2000-12-19

申请号：US319303

申请日：1999-07-28

申请人： Holger Geissler ,  Peter Gross ,  Sandra Bogdanovic

发明人： Holger Geissler ,  Peter Gross ,  Sandra Bogdanovic

IPC分类号： B01J38/00 ,  B01J31/40 ,  B01J20/34 ,  B01J38/64 ,  B01J38/68

CPC分类号： B01J31/20 ,  B01J31/04 ,  B01J31/403 ,  B01J2231/34 ,  B01J2531/845

摘要： The present invention relates to a process for recovering cobalt carbonyl catalysts used in the preparation of N-acyl-alpha-amino acid derivatives by amidocarbonylation comprising the process steps:adding aqueous hydrogen peroxide solution to the reaction solution present after the preparation of the N-acyl-.alpha.-amino acid derivative,then separating the aqueous phase containing water-soluble cobalt(II) salt from the nonaqueous product-containing phase,subsequently adding an alkali metal salt of the N-acyl-alpha-amino acid derivative to the aqueous phase from the previous process step,then separating off the precipitated cobalt salt of the N-acyl-alpha-amino acid derivative, andfinally converting the resulting cobalt salt of the N-acyl-alpha-amino acid derivative into the cobalt carbonyl catalyst in the presence of a mixture of carbon monoxide and hydrogen.

摘要翻译： PCT No.PCT / EP97 / 06707 Sec。 371日期1999年7月28日第 102（e）日期1999年7月28日PCT 1997年12月1日PCT PCT。 第WO98 / 24547号公报 日期：1998年6月11日本发明涉及一种用于回收用于通过酰胺基羰基化制备N-酰基-α-氨基酸衍生物的羰基钴催化剂的方法，其包括以下步骤：向过后的反应溶液中加入过氧化氢水溶液 制备N-酰基-α-氨基酸衍生物，然后从含非水产物的相分离含水溶性钴（II）盐的水相，随后加入N-酰基-α-氨基的碱金属盐 酸衍生物与前述工艺步骤的水相反应，然后分离N-酰基-α-氨基酸衍生物的沉淀的钴盐，最后将所得N-酰基-α-氨基酸衍生物的钴盐转化为 在一氧化碳和氢气的混合物存在下的羰基钴催化剂。