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公开(公告)号：US20090061453A1
公开(公告)日：2009-03-05
申请号：US12221297
申请日：2008-07-31
CPC分类号： G01N33/5011 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158 , G01N33/57419 , Y10T436/143333
摘要： This application describes methods and compositions for detecting and treating HLTF-associated neoplasia. Differential methylation of the HLTF nucleotide sequences has been observed in HLTF-associated neoplasia such as colon neoplasia.
摘要翻译： 本申请描述了用于检测和治疗HLTF相关瘤形成的方法和组合物。 已经在HLTF相关瘤变如结肠瘤形成中观察到HLTF核苷酸序列的差异甲基化。
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公开(公告)号：US20100209906A1
公开(公告)日：2010-08-19
申请号：US12215608
申请日：2008-06-27
CPC分类号： G01N33/57419 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/154 , G01N33/5011
摘要： This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in vimentin-associated neoplasia such as colon neoplasia.
摘要翻译： 本申请描述了用于检测和治疗波形蛋白相关瘤形成的方法和组合物。 在波形蛋白相关性肿瘤如结肠瘤形成中观察到波形蛋白核苷酸序列的差异甲基化。
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公开(公告)号：US08481707B2
公开(公告)日：2013-07-09
申请号：US12215608
申请日：2008-06-27
IPC分类号： C07H21/04
CPC分类号： G01N33/57419 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/154 , G01N33/5011
摘要： This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in vimentin-associated neoplasia such as colon neoplasia.
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公开(公告)号：US09134314B2
公开(公告)日：2015-09-15
申请号：US12676817
申请日：2008-09-05
申请人： Sanford D. Markowitz , Joseph Willis , Dawn Dawson
发明人： Sanford D. Markowitz , Joseph Willis , Dawn Dawson
IPC分类号： G01N33/574 , C12Q1/68 , G01N33/68
CPC分类号： G01N33/57407 , C12Q1/6886 , C12Q2600/158 , G01N33/57415 , G01N33/57423 , G01N33/57434 , G01N33/57438 , G01N33/57442 , G01N33/57446 , G01N33/57449 , G01N33/57488 , G01N33/6893 , G01N2500/00 , G01N2800/046
摘要： This disclosure provides methods and compositions for inhibiting immune responses. The disclosure also provides methods and compositions for inhibiting graft rejection and promoting or prolonging graft survival.
摘要翻译： 本公开提供了用于抑制免疫应答的方法和组合物。 本公开还提供了用于抑制移植物排斥和促进或延长移植物存活的方法和组合物。
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5.发明授权Aberrant methylation of C6Orf150 DNA sequences in human colorectal cancer 失效人结肠直肠癌C6Orf150 DNA序列异常甲基化公开(公告)号：US08642271B2
公开(公告)日：2014-02-04
申请号：US12870674
申请日：2010-08-27
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , C12Q2600/156 , G01N33/57419 , G01N2500/10 , G01N2800/56
摘要： This application describes methods and compositions for detecting and treating C6Orf150-associated neoplasia. Differential methylation of the C6Orf150 nucleotide sequences has been observed in C6Orf150-associated neoplasia such as colon neoplasia.
摘要翻译： 本申请描述了用于检测和治疗C6Orf150相关瘤形成的方法和组合物。 在C6Orf150相关的肿瘤形成例如结肠瘤形成中观察到C6Orf150核苷酸序列的差异甲基化。
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公开(公告)号：US06630326B2
公开(公告)日：2003-10-07
申请号：US09878905
申请日：2001-06-13
IPC分类号： C12N1563
CPC分类号： G01N33/57492 , A61K38/00 , A61K48/00 , C07K14/71 , Y02A90/26 , Y10S436/811
摘要： This invention is based on the discovery that the type II TGF&bgr; receptor (RII) is a cancer suppressor gene which is genetically inactivated (mutated) in approximately 25% of colon cancers, including nearly all colon cancers of the class identified as mutator/microsatellite instability/RER. Methods are provided for detecting inactivation of RII for use in cancer diagnosis or prognosis.
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公开(公告)号：US08722350B2
公开(公告)日：2014-05-13
申请号：US13485519
申请日：2012-05-31
申请人： Sanford D. Markowitz
发明人： Sanford D. Markowitz
IPC分类号： G01N33/574
CPC分类号： C07K14/4748 , G01N33/57419 , G01N2500/00
摘要： The disclosure provides, among other things, molecular markers for categorizing the neoplastic state of a patient, methods for using the molecular markers in diagnostic tests, nucleic acid and amino acid sequences related to the molecular markers, reagents for detection of molecular markers, and methods for identifying candidate molecular markers in highly parallel gene expression data.
摘要翻译： 本公开尤其提供了用于分类患者的肿瘤状态的分子标记，在诊断测试中使用分子标记的方法，与分子标记相关的核酸和氨基酸序列，用于检测分子标记的试剂和方法 用于在高度平行的基因表达数据中鉴定候选分子标记。
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公开(公告)号：US08221977B2
公开(公告)日：2012-07-17
申请号：US13105588
申请日：2011-05-11
申请人： Sanford D. Markowitz
发明人： Sanford D. Markowitz
IPC分类号： C12Q1/68
CPC分类号： G01N33/57419 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/154 , G01N33/5011
摘要： This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in vimentin-associated neoplasia such as colon neoplasia.
摘要翻译： 本申请描述了用于检测和治疗波形蛋白相关瘤形成的方法和组合物。 在波形蛋白相关性肿瘤如结肠瘤形成中观察到波形蛋白核苷酸序列的差异甲基化。
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公开(公告)号：US20110217708A1
公开(公告)日：2011-09-08
申请号：US13105588
申请日：2011-05-11
申请人： Sanford D. Markowitz
发明人： Sanford D. Markowitz
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57419 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/154 , G01N33/5011
摘要： This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in vimentin-associated neoplasia such as colon neoplasia.
摘要翻译： 本申请描述了用于检测和治疗波形蛋白相关瘤形成的方法和组合物。 在波形蛋白相关性肿瘤如结肠瘤形成中观察到波形蛋白核苷酸序列的差异甲基化。
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公开(公告)号：US20100284989A1
公开(公告)日：2010-11-11
申请号：US12774641
申请日：2010-05-05
IPC分类号： A61K38/44 , A61K31/415 , A61K31/7088 , A61P35/00 , A61P29/00 , A61P37/00 , C12Q1/32 , G01N33/53 , C12Q1/68
CPC分类号： A61K39/395 , A61K31/19 , A61K31/415 , A61K31/517 , A61K31/60 , A61K31/7088 , A61K38/02 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/573 , G01N33/57419 , G01N2333/902 , G01N2800/52
摘要： The disclosure provides, among other things, a method of decreasing resistance to the chemopreventive properties of non-steroidal anti-inflammatory agents, e.g., celecoxib, particularly in the prevention of cancer, e.g., colon cancer, by increasing the levels or activity of 15-hydroxyprostaglandin dehydrogenase (15-PGDH). The disclosure also provides a method of identifying compounds that upregulate or reactivate 15-PGDH. The disclosure also provides a method of identifying an individual suitable for treatment with a non-steroidal anti-inflammatory agent in the treatment or prevention of colon cancer.
摘要翻译： 本公开尤其提供了降低对非甾体抗炎剂（例如塞来考昔）的化学预防性能的抗性的方法，特别是在预防癌症（例如结肠癌）中，通过增加15的水平或活性 - 羟基前列腺素脱氢酶（15-PGDH）。 本公开还提供了鉴定上调或重新激活15-PGDH的化合物的方法。 本公开还提供了一种鉴定适合用非甾体抗炎剂治疗或预防结肠癌的个体的方法。
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