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公开(公告)号：US20060104983A1
公开(公告)日：2006-05-18
申请号：US11265065
申请日：2005-11-02
申请人： Sanjay Awasthi , Sharad Singhal , Sushma Yadav
发明人： Sanjay Awasthi , Sharad Singhal , Sushma Yadav
IPC分类号： A61K48/00 , A61K31/426 , C40B40/08 , A61K39/395
CPC分类号： C12N15/113 , A61K48/00 , C07K16/28 , C07K2317/34 , C07K2317/77 , C12N2310/14 , C12N2310/315
摘要： The present invention includes methods and compositions used to regulate glucose and insulin levels in subjects in need thereof. Compositions are regions that recognize a ralA binding protein 1 and directly affects transport activity and membrane association of the ralA binding protein 1. The compositions are used to identify chemical compounds (e.g., antibodies, si-RNA and small molecules) that recognize ralA binding protein 1 and to identify medicines used to regulate glucose and insulin levels in subjects in need thereof. Compositions may be used screen chemical libraries for compounds that bind the ralA binding protein 1 and effect its transport activity and/or membrane association.
摘要翻译： 本发明包括用于在有需要的受试者中调节葡萄糖和胰岛素水平的方法和组合物。 组合物是识别ralA结合蛋白1并直接影响ralA结合蛋白1的转运活性和膜缔合的区域。该组合物用于鉴定识别ralA结合蛋白的化学化合物（例如，抗体，si-RNA和小分子） 并鉴定用于调节有需要的受试者中的葡萄糖和胰岛素水平的药物。 组合物可以用于结合ralA结合蛋白1并影响其转运活性和/或膜缔合的化合物的屏幕化学文库。
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公开(公告)号：US20060182749A1
公开(公告)日：2006-08-17
申请号：US11264910
申请日：2005-11-02
申请人： Sanjay Awasthi , Sharad Singhal , Sushma Yadav
发明人： Sanjay Awasthi , Sharad Singhal , Sushma Yadav
IPC分类号： A61K48/00 , A61K39/395
CPC分类号： G01N33/5011 , A61K31/713 , A61K38/1709 , A61K39/3955 , A61K48/00 , A61K2039/505 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/34 , C07K2317/76 , C12N15/113 , C12N15/1138 , C12N2310/11 , C12N2310/14 , G01N2333/705
摘要： The present invention is a composition identified as a region of ralA binding protein 1, wherein the region neighbors a membrane-associated portion of the ralA binding protein 1, reduces transport activity and membrane association of the ralA binding protein 1 and kills cells undergoing uncontrolled cell growth in a subject that has cells undergoing uncontrolled cell growth. The region is used to generate medicines that kill malignant cells and tumorigenic cells. Medicines may be in the form of antibodies, si-RNA and small molecules that recognize the region.
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公开(公告)号：US20050123594A1
公开(公告)日：2005-06-09
申请号：US10713578
申请日：2003-11-13
申请人： Sanjay Awasthi , Sharad Singhal
发明人： Sanjay Awasthi , Sharad Singhal
CPC分类号： A61K9/1275 , A61K9/127 , A61K38/16 , A61K38/1709 , A61K45/06 , C07K14/00 , C07K14/245 , C07K14/47 , C07K16/40 , C07K2317/76
摘要： Generally, and in one form, the present invention is a method of method of preparing a proteoliposome comprising the step of contacting a liposome with an effective portion of RLIP76 to create a proteoliposome. In another form, the present invention is a proteoliposomal composition comprising a liposome and an effective portion of RLIP76. In yet another form, the present invention is a kit for reducing the concentration of toxic compounds and their by-products comprising an effective dose of a proteoliposome, wherein the proteoliposome is a liposome and an effective portion of RLIP76 and an instructional pamphlet. Applications of the present invention include the protection and treatment of mammals and the environment against the accumulation of toxic compounds. The present invention prevents accumulation of one or more toxic compounds, reduces the concentration of toxic compounds, and protects against further contamination with one or more toxic compounds.
摘要翻译： 通常，在一种形式中，本发明是制备蛋白脂质体的方法的方法，其包括使脂质体与有效部分的RLIP76接触以产生蛋白脂质体的步骤。 在另一种形式中，本发明是包含脂质体和RLIP76有效部分的蛋白脂质体组合物。 在另一种形式中，本发明是用于降低有毒化合物及其副产物浓度的试剂盒，其包含有效剂量的蛋白脂质体，其中所述蛋白脂质体是脂质体，RLIP76的有效部分和教学小册子。 本发明的应用包括对有毒化合物的积累的哺乳动物和环境的保护和治疗。 本发明防止一种或多种有毒化合物的积聚，降低有毒化合物的浓度，并防止一种或多种有毒化合物的进一步污染。
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公开(公告)号：US20060104982A1
公开(公告)日：2006-05-18
申请号：US11265052
申请日：2005-11-02
申请人： Sanjay Awasthi , Sharad Singhal , Sushma Yadav
发明人： Sanjay Awasthi , Sharad Singhal , Sushma Yadav
IPC分类号： A61K39/395 , C40B40/08 , A61K48/00
CPC分类号： C07K14/705 , A61K48/00 , C07K16/28 , C07K16/30 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315
摘要： The present invention is a composition identified as a coding region of ralA binding protein 1, wherein the region neighbors a membrane-associated portion of the ralA binding protein 1 and directly effects transport activity and membrane association of the ralA binding protein 1. The composition is used to identify chemical compounds (e.g., antibodies, si-RNA and small molecules) that recognize ralA binding protein 1. The composition and methods of using the composition identify, via screening of chemical libraries, compounds that bind ralA binding protein 1 and medicines for the treatment of seizure disorders.
摘要翻译： 本发明是鉴定为ralA结合蛋白1的编码区的组合物，其中所述区域与ralA结合蛋白1的膜相关部分相邻，并直接影响ralA结合蛋白1的转运活性和膜缔合。组合物为 用于鉴定识别ralA结合蛋白1的化学化合物（例如，抗体，si-RNA和小分子）。使用该组合物的组合物和方法通过化学文库筛选鉴定结合ralA结合蛋白1的化合物和药物 治疗癫痫发作。
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公开(公告)号：US20100124566A1
公开(公告)日：2010-05-20
申请号：US12460781
申请日：2009-07-24
申请人： Sanjay Awasthi , Sharad S. Singhal
发明人： Sanjay Awasthi , Sharad S. Singhal
CPC分类号： C07K16/40 , C07K2317/76
摘要： Methods of preparing a proteoliposome comprise the step of contacting a liposome with an effective portion of RalBP1 to create a proteoliposome. RalBP1 is effective for the protection and treatment of mammals and the environment against the accumulation of toxic compounds, and prevents accumulation of one or more toxic compounds, reduces the concentration of toxic compounds, and protects against further contamination with one or more toxic compounds. In addition, RalBP1 is effective for the protection and treatment of mammals against the effects of ionizing radiation.
摘要翻译： 制备蛋白脂质体的方法包括使脂质体与RalBP1的有效部分接触以产生蛋白脂质体的步骤。 RalBP1对哺乳动物和环境的保护和治疗有效，防止有毒化合物的积累，并防止一种或多种有毒化合物的积聚，降低有毒化合物的浓度，并防止进一步污染一种或多种有毒化合物。 此外，RalBP1对于保护和治疗哺乳动物免受电离辐射的影响是有效的。
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公开(公告)号：US08163692B2
公开(公告)日：2012-04-24
申请号：US12460781
申请日：2009-07-24
申请人： Sanjay Awasthi , Sharad S. Singhal
发明人： Sanjay Awasthi , Sharad S. Singhal
IPC分类号： A61K38/00
CPC分类号： C07K16/40 , C07K2317/76
摘要： Methods of preparing a proteoliposome comprise the step of contacting a liposome with an effective portion of RalBP1 to create a proteoliposome. RalBP1 is effective for the protection and treatment of mammals and the environment against the accumulation of toxic compounds, and prevents accumulation of one or more toxic compounds, reduces the concentration of toxic compounds, and protects against further contamination with one or more toxic compounds. In addition, RalBP1 is effective for the protection and treatment of mammals against the effects of ionizing radiation.
摘要翻译： 制备蛋白脂质体的方法包括使脂质体与RalBP1的有效部分接触以产生蛋白脂质体的步骤。 RalBP1对哺乳动物和环境的保护和治疗有效，防止有毒化合物的积累，并防止一种或多种有毒化合物的积聚，降低有毒化合物的浓度，并防止进一步污染一种或多种有毒化合物。 此外，RalBP1对于保护和治疗哺乳动物免受电离辐射的影响是有效的。
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公开(公告)号：US20080279919A1
公开(公告)日：2008-11-13
申请号：US11741447
申请日：2007-04-27
申请人： Sanjay Awasthi , Sharad S. Singhal
发明人： Sanjay Awasthi , Sharad S. Singhal
CPC分类号： A61K9/1275 , A61K9/127 , A61K38/16 , A61K38/1709 , A61K45/06 , C07K14/00 , C07K14/245 , C07K14/47 , C07K16/40 , C07K2317/76
摘要： Methods of preparing a proteoliposome comprise the step of contacting a liposome with an effective portion of RalBP1 to create a proteoliposome. RalBP1 is effective for the protection and treatment of mammals and the environment against the accumulation of toxic compounds and prevents accumulation of one or more toxic compounds, reduces the concentration of toxic compounds, and protects against further contamination with one or more toxic compounds.
摘要翻译： 制备蛋白脂质体的方法包括使脂质体与RalBP1的有效部分接触以产生蛋白脂质体的步骤。 RalBP1对哺乳动物和环境的保护和治疗有效，防止有毒化合物的积累，并防止一种或多种有毒化合物的积聚，降低有毒化合物的浓度，并防止进一步污染一种或多种有毒化合物。
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公开(公告)号：US08486410B2
公开(公告)日：2013-07-16
申请号：US11741447
申请日：2007-04-27
申请人： Sanjay Awasthi , Sharad S. Singhal
发明人： Sanjay Awasthi , Sharad S. Singhal
CPC分类号： A61K9/1275 , A61K9/127 , A61K38/16 , A61K38/1709 , A61K45/06 , C07K14/00 , C07K14/245 , C07K14/47 , C07K16/40 , C07K2317/76
摘要： Methods of preparing a proteoliposome comprise the step of contacting a liposome with an effective portion of RalBP1 to create a proteoliposome. RalBP1 is effective for the protection and treatment of mammals and the environment against the accumulation of toxic compounds and prevents accumulation of one or more toxic compounds, reduces the concentration of toxic compounds, and protects against further contamination with one or more toxic compounds.
摘要翻译： 制备蛋白脂质体的方法包括使脂质体与RalBP1的有效部分接触以产生蛋白脂质体的步骤。 RalBP1对哺乳动物和环境的保护和治疗有效，防止有毒化合物的积累，并防止一种或多种有毒化合物的积聚，降低有毒化合物的浓度，并防止进一步污染一种或多种有毒化合物。
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公开(公告)号：US08246967B2
公开(公告)日：2012-08-21
申请号：US11496837
申请日：2006-08-01
CPC分类号： C12N5/0693 , A61K31/435 , A61K49/0017 , C07F15/0046 , C07F15/0053 , C12N2500/10
摘要： Compositions and methods for modifying one or more biologic targets are provided. Suitable targets include cells, DNA, proteins, enzymes, and/or a subject in need thereof. The compositions may exist as a monomer or multimer and are active in a biologic environment with enhanced activity in hypoxic environments and, thus, exhibit improved specificity for hypoxic biologic targets (e.g., tumorigenic cells and those undergoing uncontrolled cell growth). A composition typically comprises a complex with an overall charge of 2+ or greater having at least one ruthenium atom attached to a redox active ligand. The redox active ligand helps maintain separation of more than one ruthenium atom. Suitable compositions may further include a terminal ligand comprising a heterocyclic aromatic compound. When provided to a biologic target, the composition modifies the biologic target and no additional compounds need be provided. Suitable compositions are typically catalytic and regenerative in the presence of a reducing agent.
摘要翻译： 提供了修改一个或多个生物靶标的组合物和方法。 合适的靶标包括细胞，DNA，蛋白质，酶和/或有需要的受试者。 组合物可以作为单体或多聚体存在，并且在缺氧环境中具有增强活性的生物环境中具有活性，因此对缺氧生物靶标（例如致瘤细胞和经受不受控制的细胞生长的那些）表现出改善的特异性。 组合物通常包含具有2+或更大的总电荷的复合物，其具有连接到氧化还原活性配体的至少一个钌原子。 氧化还原活性配体有助于保持多于一个钌原子的分离。 合适的组合物还可以包括包含杂环芳族化合物的末端配体。 当提供给生物靶标时，组合物修饰生物靶标，不需要提供其他化合物。 合适的组合物通常在还原剂存在下是催化和再生的。
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公开(公告)号：US20140010864A1
公开(公告)日：2014-01-09
申请号：US13912788
申请日：2013-06-07
申请人： Sanjay Awasthi , Sharad S. Singhal
发明人： Sanjay Awasthi , Sharad S. Singhal
CPC分类号： A61K9/1275 , A61K9/127 , A61K38/16 , A61K38/1709 , A61K45/06 , C07K14/00 , C07K14/245 , C07K14/47 , C07K16/40 , C07K2317/76
摘要： Methods of preparing a proteoliposome comprise the step of contacting a liposome with an effective portion of RalBP1 to create a proteoliposome. RalBP1 is effective for the protection and treatment of mammals and the environment against the accumulation of toxic compounds and prevents accumulation of one or more toxic compounds, reduces the concentration of toxic compounds, and protects against further contamination with one or more toxic compounds.
摘要翻译： 制备蛋白脂质体的方法包括将脂质体与RalBP1的有效部分接触以产生蛋白脂质体的步骤。 RalBP1对哺乳动物和环境的保护和治疗有效，防止有毒化合物的积累，并防止一种或多种有毒化合物的积聚，降低有毒化合物的浓度，并防止进一步污染一种或多种有毒化合物。
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