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1.
公开(公告)号:US20060104983A1
公开(公告)日:2006-05-18
申请号:US11265065
申请日:2005-11-02
申请人: Sanjay Awasthi , Sharad Singhal , Sushma Yadav
发明人: Sanjay Awasthi , Sharad Singhal , Sushma Yadav
IPC分类号: A61K48/00 , A61K31/426 , C40B40/08 , A61K39/395
CPC分类号: C12N15/113 , A61K48/00 , C07K16/28 , C07K2317/34 , C07K2317/77 , C12N2310/14 , C12N2310/315
摘要: The present invention includes methods and compositions used to regulate glucose and insulin levels in subjects in need thereof. Compositions are regions that recognize a ralA binding protein 1 and directly affects transport activity and membrane association of the ralA binding protein 1. The compositions are used to identify chemical compounds (e.g., antibodies, si-RNA and small molecules) that recognize ralA binding protein 1 and to identify medicines used to regulate glucose and insulin levels in subjects in need thereof. Compositions may be used screen chemical libraries for compounds that bind the ralA binding protein 1 and effect its transport activity and/or membrane association.
摘要翻译: 本发明包括用于在有需要的受试者中调节葡萄糖和胰岛素水平的方法和组合物。 组合物是识别ralA结合蛋白1并直接影响ralA结合蛋白1的转运活性和膜缔合的区域。该组合物用于鉴定识别ralA结合蛋白的化学化合物(例如,抗体,si-RNA和小分子) 并鉴定用于调节有需要的受试者中的葡萄糖和胰岛素水平的药物。 组合物可以用于结合ralA结合蛋白1并影响其转运活性和/或膜缔合的化合物的屏幕化学文库。
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公开(公告)号:US20060104982A1
公开(公告)日:2006-05-18
申请号:US11265052
申请日:2005-11-02
申请人: Sanjay Awasthi , Sharad Singhal , Sushma Yadav
发明人: Sanjay Awasthi , Sharad Singhal , Sushma Yadav
IPC分类号: A61K39/395 , C40B40/08 , A61K48/00
CPC分类号: C07K14/705 , A61K48/00 , C07K16/28 , C07K16/30 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315
摘要: The present invention is a composition identified as a coding region of ralA binding protein 1, wherein the region neighbors a membrane-associated portion of the ralA binding protein 1 and directly effects transport activity and membrane association of the ralA binding protein 1. The composition is used to identify chemical compounds (e.g., antibodies, si-RNA and small molecules) that recognize ralA binding protein 1. The composition and methods of using the composition identify, via screening of chemical libraries, compounds that bind ralA binding protein 1 and medicines for the treatment of seizure disorders.
摘要翻译: 本发明是鉴定为ralA结合蛋白1的编码区的组合物,其中所述区域与ralA结合蛋白1的膜相关部分相邻,并直接影响ralA结合蛋白1的转运活性和膜缔合。组合物为 用于鉴定识别ralA结合蛋白1的化学化合物(例如,抗体,si-RNA和小分子)。使用该组合物的组合物和方法通过化学文库筛选鉴定结合ralA结合蛋白1的化合物和药物 治疗癫痫发作。
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公开(公告)号:US20060182749A1
公开(公告)日:2006-08-17
申请号:US11264910
申请日:2005-11-02
申请人: Sanjay Awasthi , Sharad Singhal , Sushma Yadav
发明人: Sanjay Awasthi , Sharad Singhal , Sushma Yadav
IPC分类号: A61K48/00 , A61K39/395
CPC分类号: G01N33/5011 , A61K31/713 , A61K38/1709 , A61K39/3955 , A61K48/00 , A61K2039/505 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/34 , C07K2317/76 , C12N15/113 , C12N15/1138 , C12N2310/11 , C12N2310/14 , G01N2333/705
摘要: The present invention is a composition identified as a region of ralA binding protein 1, wherein the region neighbors a membrane-associated portion of the ralA binding protein 1, reduces transport activity and membrane association of the ralA binding protein 1 and kills cells undergoing uncontrolled cell growth in a subject that has cells undergoing uncontrolled cell growth. The region is used to generate medicines that kill malignant cells and tumorigenic cells. Medicines may be in the form of antibodies, si-RNA and small molecules that recognize the region.
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公开(公告)号:US20050123594A1
公开(公告)日:2005-06-09
申请号:US10713578
申请日:2003-11-13
申请人: Sanjay Awasthi , Sharad Singhal
发明人: Sanjay Awasthi , Sharad Singhal
CPC分类号: A61K9/1275 , A61K9/127 , A61K38/16 , A61K38/1709 , A61K45/06 , C07K14/00 , C07K14/245 , C07K14/47 , C07K16/40 , C07K2317/76
摘要: Generally, and in one form, the present invention is a method of method of preparing a proteoliposome comprising the step of contacting a liposome with an effective portion of RLIP76 to create a proteoliposome. In another form, the present invention is a proteoliposomal composition comprising a liposome and an effective portion of RLIP76. In yet another form, the present invention is a kit for reducing the concentration of toxic compounds and their by-products comprising an effective dose of a proteoliposome, wherein the proteoliposome is a liposome and an effective portion of RLIP76 and an instructional pamphlet. Applications of the present invention include the protection and treatment of mammals and the environment against the accumulation of toxic compounds. The present invention prevents accumulation of one or more toxic compounds, reduces the concentration of toxic compounds, and protects against further contamination with one or more toxic compounds.
摘要翻译: 通常,在一种形式中,本发明是制备蛋白脂质体的方法的方法,其包括使脂质体与有效部分的RLIP76接触以产生蛋白脂质体的步骤。 在另一种形式中,本发明是包含脂质体和RLIP76有效部分的蛋白脂质体组合物。 在另一种形式中,本发明是用于降低有毒化合物及其副产物浓度的试剂盒,其包含有效剂量的蛋白脂质体,其中所述蛋白脂质体是脂质体,RLIP76的有效部分和教学小册子。 本发明的应用包括对有毒化合物的积累的哺乳动物和环境的保护和治疗。 本发明防止一种或多种有毒化合物的积聚,降低有毒化合物的浓度,并防止一种或多种有毒化合物的进一步污染。
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公开(公告)号:US20150242641A1
公开(公告)日:2015-08-27
申请号:US14421734
申请日:2012-09-12
申请人: Jun Li , Ram Swaminathan , Sharad Singhal
发明人: Jun Li , Ram Swaminathan , Sharad Singhal
CPC分类号: G16H10/60 , G06F17/30109 , G06F17/30327 , G06F17/30997 , G06F19/00 , G06F21/602 , G06F21/64 , G06Q10/10 , G06Q50/24 , G06Q2220/10 , G16H10/40 , H04L63/0457 , H04L63/064
摘要: A method performed by a processing system includes reconstructing a metadata tree of a patient from a metadata tree journal, the metadata tree including a plurality of references to a corresponding plurality of encrypted electronic health records of the patient in an encrypted data store, and validating the metadata tree by comparing first integrity information of the metadata tree to second integrity information corresponding to the metadata tree journal provided by a metadata integrity validator.
摘要翻译: 由处理系统执行的方法包括从元数据树日志重建患者的元数据树,所述元数据树包括对加密数据存储中的患者的相应多个加密的电子健康记录的多个引用,以及验证 通过将元数据树的第一完整性信息与由元数据完整性验证器提供的元数据树日志对应的第二完整性信息进行比较来确定元数据树。
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公开(公告)号:US20150220746A1
公开(公告)日:2015-08-06
申请号:US14421759
申请日:2012-08-30
申请人: Jun Li , Ram Swaminathan , Sharad Singhal
发明人: Jun Li , Ram Swaminathan , Sharad Singhal
摘要: A method performed by a processing system includes determining a location in a metadata tree of a patient for an electronic health record, generating a record key for the electronic health record based on the location and a provider key corresponding to a provider, the provider key generated from a patient key corresponding to the patient, encrypting the electronic health record using the record key to generate a encrypted record, and providing the encrypted record to an encrypted data store.
摘要翻译: 由处理系统执行的方法包括确定用于电子健康记录的患者的元数据树中的位置,基于所述位置生成用于所述电子健康记录的记录密钥和与提供者对应的提供者密钥,生成的提供者密钥 从对应于患者的患者密钥,使用记录密钥对电子健康记录进行加密,以产生加密记录,并将加密记录提供给加密数据存储。
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公开(公告)号:US20150029029A1
公开(公告)日:2015-01-29
申请号:US14344862
申请日:2011-09-29
申请人: Matthew Alan Hopcroft , Jerome Rolia , Sharad Singhal , Charles Edgar Bess , Henri J. Suermondt
发明人: Matthew Alan Hopcroft , Jerome Rolia , Sharad Singhal , Charles Edgar Bess , Henri J. Suermondt
IPC分类号: G08B21/22
CPC分类号: G08B21/22 , A61B5/0002 , A61B5/11 , A61B5/6891 , A61B2562/0219
摘要: A system includes a patient environment in an area, a first accelerometer attached to the first patient environment, a second accelerometer disposed in the area, and a processing system to detect an activity of a patient in the area using vibration data received from the first and the second accelerometers.
摘要翻译: 系统包括区域中的患者环境,附接到第一患者环境的第一加速度计,设置在该区域中的第二加速计,以及处理系统,使用从第一和第二患者环境接收的振动数据来检测患者在该区域中的活动, 第二加速度计。
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公开(公告)号:US08917872B2
公开(公告)日:2014-12-23
申请号:US13177228
申请日:2011-07-06
申请人: Jun Li , Ram Swaminathan , Sharad Singhal
发明人: Jun Li , Ram Swaminathan , Sharad Singhal
IPC分类号: H04L9/08
CPC分类号: H04L9/085 , H04L9/0888
摘要: Systems, methods, and machine-readable and executable instructions are provided for encryption key storage. Encryption key storage may include associating each of a plurality of identifiers with a different one of a plurality of key fragment stores, determining a plurality of indexes, where each of the plurality of indexes is based upon a handle provided by a customer, an authorization token provided by the customer, and a different one of the plurality of identifiers, partitioning an encryption key provided by the customer into a number of encryption key fragments, and distributing the plurality of indexes and the number of encryption key fragments to the plurality of key fragment stores. The handle can be a uniform resource identifier, for instance.
摘要翻译: 提供了系统,方法和机器可读和可执行指令用于加密密钥存储。 加密密钥存储可以包括将多个标识符中的每一个与多个密钥片段存储中的不同标识符相关联,确定多个索引,其中多个索引中的每个索引基于由客户提供的句柄,授权令牌 由客户提供的多个标识符中的不同的标识符,将由客户提供的加密密钥划分成多个加密密钥片段,并将多个索引和加密密钥片段的数量分配给多个密钥片段 商店。 例如,句柄可以是统一的资源标识符。
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9.
公开(公告)号:US20140358041A1
公开(公告)日:2014-12-04
申请号:US14372416
申请日:2012-04-18
申请人: Matthew Alan Hopcroft , Jerome Rolia , Sharad Singhal , Charles Edgar Bess , Henri J. Suermondt
发明人: Matthew Alan Hopcroft , Jerome Rolia , Sharad Singhal , Charles Edgar Bess , Henri J. Suermondt
IPC分类号: A61B5/11
CPC分类号: A61B5/1117 , A61B5/0002 , A61B5/11 , A61B5/1126 , A61B5/4023 , A61B5/6891 , A61B5/7275 , A61B2562/0219 , A61B2562/028
摘要: A system includes an accelerometer worn by a patient to capture physiological data of the patient and transmit the physiological data and a processing system to receive the physiological data and assess a physical stability of the patient using the physiological data.
摘要翻译: 系统包括由患者佩戴的用于捕获患者的生理数据并传送生理数据的加速度计和处理系统以接收生理数据并使用生理数据评估患者的物理稳定性。
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公开(公告)号:US20130111349A1
公开(公告)日:2013-05-02
申请号:US13283981
申请日:2011-10-28
申请人: Shi Xing Yan , Guopeng Zhao , Ding Ma , Bee Sung Lee , Sharad Singhal
发明人: Shi Xing Yan , Guopeng Zhao , Ding Ma , Bee Sung Lee , Sharad Singhal
CPC分类号: H04L67/2838 , G06F9/5072 , H04L41/0806 , H04L41/22 , H04L41/5054 , H04L41/5096
摘要: Service models may be generated in response to services exposed by two or more IaaS service providers, and an interface may be provided for selection and specification of the service models.
摘要翻译: 服务模型可以响应于由两个或多个IaaS服务提供商公开的服务而产生,并且可以提供用于选择和指定服务模型的接口。
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