Therapies for the regulation of insulin and glucose using RLIP76
    1.
    发明申请
    Therapies for the regulation of insulin and glucose using RLIP76 审中-公开
    使用RLIP76调节胰岛素和葡萄糖的疗法

    公开(公告)号:US20060104983A1

    公开(公告)日:2006-05-18

    申请号:US11265065

    申请日:2005-11-02

    摘要: The present invention includes methods and compositions used to regulate glucose and insulin levels in subjects in need thereof. Compositions are regions that recognize a ralA binding protein 1 and directly affects transport activity and membrane association of the ralA binding protein 1. The compositions are used to identify chemical compounds (e.g., antibodies, si-RNA and small molecules) that recognize ralA binding protein 1 and to identify medicines used to regulate glucose and insulin levels in subjects in need thereof. Compositions may be used screen chemical libraries for compounds that bind the ralA binding protein 1 and effect its transport activity and/or membrane association.

    摘要翻译: 本发明包括用于在有需要的受试者中调节葡萄糖和胰岛素水平的方法和组合物。 组合物是识别ralA结合蛋白1并直接影响ralA结合蛋白1的转运活性和膜缔合的区域。该组合物用于鉴定识别ralA结合蛋白的化学化合物(例如,抗体,si-RNA和小分子) 并鉴定用于调节有需要的受试者中的葡萄糖和胰岛素水平的药物。 组合物可以用于结合ralA结合蛋白1并影响其转运活性和/或膜缔合的化合物的屏幕化学文库。

    Therapies for seizure disorders using RLIP76
    2.
    发明申请
    Therapies for seizure disorders using RLIP76 审中-公开
    使用RLIP76治疗癫痫发作的疗法

    公开(公告)号:US20060104982A1

    公开(公告)日:2006-05-18

    申请号:US11265052

    申请日:2005-11-02

    摘要: The present invention is a composition identified as a coding region of ralA binding protein 1, wherein the region neighbors a membrane-associated portion of the ralA binding protein 1 and directly effects transport activity and membrane association of the ralA binding protein 1. The composition is used to identify chemical compounds (e.g., antibodies, si-RNA and small molecules) that recognize ralA binding protein 1. The composition and methods of using the composition identify, via screening of chemical libraries, compounds that bind ralA binding protein 1 and medicines for the treatment of seizure disorders.

    摘要翻译: 本发明是鉴定为ralA结合蛋白1的编码区的组合物,其中所述区域与ralA结合蛋白1的膜相关部分相邻,并直接影响ralA结合蛋白1的转运活性和膜缔合。组合物为 用于鉴定识别ralA结合蛋白1的化学化合物(例如,抗体,si-RNA和小分子)。使用该组合物的组合物和方法通过化学文库筛选鉴定结合ralA结合蛋白1的化合物和药物 治疗癫痫发作。

    Liposomes for protection against toxic compounds
    4.
    发明申请
    Liposomes for protection against toxic compounds 审中-公开
    用于保护有毒化合物的脂质体

    公开(公告)号:US20050123594A1

    公开(公告)日:2005-06-09

    申请号:US10713578

    申请日:2003-11-13

    IPC分类号: A61K9/127 A61K38/16 C07K16/40

    摘要: Generally, and in one form, the present invention is a method of method of preparing a proteoliposome comprising the step of contacting a liposome with an effective portion of RLIP76 to create a proteoliposome. In another form, the present invention is a proteoliposomal composition comprising a liposome and an effective portion of RLIP76. In yet another form, the present invention is a kit for reducing the concentration of toxic compounds and their by-products comprising an effective dose of a proteoliposome, wherein the proteoliposome is a liposome and an effective portion of RLIP76 and an instructional pamphlet. Applications of the present invention include the protection and treatment of mammals and the environment against the accumulation of toxic compounds. The present invention prevents accumulation of one or more toxic compounds, reduces the concentration of toxic compounds, and protects against further contamination with one or more toxic compounds.

    摘要翻译: 通常,在一种形式中,本发明是制备蛋白脂质体的方法的方法,其包括使脂质体与有效部分的RLIP76接触以产生蛋白脂质体的步骤。 在另一种形式中,本发明是包含脂质体和RLIP76有效部分的蛋白脂质体组合物。 在另一种形式中,本发明是用于降低有毒化合物及其副产物浓度的试剂盒,其包含有效剂量的蛋白脂质体,其中所述蛋白脂质体是脂质体,RLIP76的有效部分和教学小册子。 本发明的应用包括对有毒化合物的积累的哺乳动物和环境的保护和治疗。 本发明防止一种或多种有毒化合物的积聚,降低有毒化合物的浓度,并防止一种或多种有毒化合物的进一步污染。

    ENCRYPTED DATA STORE FOR RECORDS
    6.
    发明申请
    ENCRYPTED DATA STORE FOR RECORDS 有权
    加密数据存储记录

    公开(公告)号:US20150220746A1

    公开(公告)日:2015-08-06

    申请号:US14421759

    申请日:2012-08-30

    IPC分类号: G06F21/60 G06F19/00

    摘要: A method performed by a processing system includes determining a location in a metadata tree of a patient for an electronic health record, generating a record key for the electronic health record based on the location and a provider key corresponding to a provider, the provider key generated from a patient key corresponding to the patient, encrypting the electronic health record using the record key to generate a encrypted record, and providing the encrypted record to an encrypted data store.

    摘要翻译: 由处理系统执行的方法包括确定用于电子健康记录的患者的元数据树中的位置,基于所述位置生成用于所述电子健康记录的记录密钥和与提供者对应的提供者密钥,生成的提供者密钥 从对应于患者的患者密钥,使用记录密钥对电子健康记录进行加密,以产生加密记录,并将加密记录提供给加密数据存储。

    Encryption key storage with key fragment stores
    8.
    发明授权
    Encryption key storage with key fragment stores 有权
    加密密钥存储与关键片段存储

    公开(公告)号:US08917872B2

    公开(公告)日:2014-12-23

    申请号:US13177228

    申请日:2011-07-06

    IPC分类号: H04L9/08

    CPC分类号: H04L9/085 H04L9/0888

    摘要: Systems, methods, and machine-readable and executable instructions are provided for encryption key storage. Encryption key storage may include associating each of a plurality of identifiers with a different one of a plurality of key fragment stores, determining a plurality of indexes, where each of the plurality of indexes is based upon a handle provided by a customer, an authorization token provided by the customer, and a different one of the plurality of identifiers, partitioning an encryption key provided by the customer into a number of encryption key fragments, and distributing the plurality of indexes and the number of encryption key fragments to the plurality of key fragment stores. The handle can be a uniform resource identifier, for instance.

    摘要翻译: 提供了系统,方法和机器可读和可执行指令用于加密密钥存储。 加密密钥存储可以包括将多个标识符中的每一个与多个密钥片段存储中的不同标识符相关联,确定多个索引,其中多个索引中的每个索引基于由客户提供的句柄,授权令牌 由客户提供的多个标识符中的不同的标识符,将由客户提供的加密密钥划分成多个加密密钥片段,并将多个索引和加密密钥片段的数量分配给多个密钥片段 商店。 例如,句柄可以是统一的资源标识符。