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    ENHANCED SENSITIVITY CARBON NANOTUBES AS TARGETED PHOTOACOUSTIC MOLECULAR IMAGING AGENTS
    1.
    发明申请
    ENHANCED SENSITIVITY CARBON NANOTUBES AS TARGETED PHOTOACOUSTIC MOLECULAR IMAGING AGENTS 审中-公开
    增强型敏感性碳纳米管作为靶向光电分子成像剂

    公开(公告)号：US20100074845A1

    公开(公告)日：2010-03-25

    申请号：US12552313

    申请日：2009-09-02

    申请人： Sanjiv S. Gambhir ,  Hongjie Dai ,  Zhuang Liu ,  Adam de la Zerda

    发明人： Sanjiv S. Gambhir ,  Hongjie Dai ,  Zhuang Liu ,  Adam de la Zerda

    IPC分类号： A61K49/00 ,  C07D209/56 ,  C07K5/08 ,  C07K16/46 ,  C07H21/00 ,  C07H1/00 ,  C07J1/00 ,  C07D239/00 ,  C07D473/00 ,  C07C53/00

    CPC分类号： A61K49/225 ,  B82Y5/00

    摘要： The present disclosure provides contrast photoacoustic probes, and compositions comprising such probes, designed to non-invasively detect and monitor various disease states, or targets within a subject human or animal. The probes are designed to be optically excited in tissue, ultimately generating thermal energy, which is transformed into acoustic energy by the response of the aqueous environment in the subject to the thermal emissions. The acoustic energy (sound) can then be detected by suitably applied transducers and digitally transformed into images indicating the location of the probe in the subject. One aspect of the disclosure encompasses photoacoustic probes that comprise: a carbon nanotube and a plurality of dye molecules bound to the carbon nanotube. The probes may further comprise a targeting moiety for localizing the probe at the site of a specific target. Another aspect of the present disclosure encompasses methods of detecting a target in animal or human subject, comprising: delivering a photoacoustic probe to a subject, allowing the photoacoustic probe to selectively bind to a target of the subject; and illuminating the system with an optical energy absorbable by the photoacoustic probe to generate an acoustic signal; and detecting the acoustic signal, thereby detecting the target in the subject.

    摘要翻译： 本公开提供了对比度光声探针和包含这样的探针的组合物，其被设计成非侵入性地检测和监测各种疾病状态或受试者人或动物内的靶标。 探针被设计为在组织中被光学激发，最终产生热能，其通过受试者中的水性环境对热发射的响应而转化为声能。 然后可以通过适当地应用的换能器来检测声能（声音），并且数字地转换成指示被检体中探针位置的图像。 本公开的一个方面包括光声探测器，其包含：碳纳米管和结合到碳纳米管的多个染料分子。 探针还可以包含用于在特定靶位点定位探针的靶向部分。 本公开的另一方面包括检测动物或人类受试者中的靶的方法，包括：将光声探测器递送至受试者，允许光声探测器选择性地结合受试者的靶标; 并用光声探测器吸收的光能照射该系统以产生声信号; 并检测声信号，从而检测被摄体中的目标。